A highly efficient method for solvent‐free synthesis of bis(arylmethylidene)piperidinones

Abstract

A remarkably efficient double crossed aldol condensation of piperidin-4-one with various aromatic aldehydes is described at room temperature in the presence of diethylamine and lithium perchlorate under solvent-free conditions. Excellent yields of 3,5-bis(arylmethylidene)piperidinones are achieved in a facile one-pot general procedure. Structure of the products is determined by spectroscopic methods and elemental analysis.