A Highly Effective Sulfamic Acid/Methanol Catalytic System for the Synthesis of Benzimidazole Derivatives at Room Temperature

Zhang, Zhan‐Hui; Li, Tong‐Shuang; Li, Jian‐Jiong

doi:10.1007/s00706-006-0566-1

Cited by 61 publications

(21 citation statements)

References 16 publications

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“…4,7‐Dibromo‐1‐methyl‐1 H ‐benzimidazole,21 1,3,5‐tri(4‐pinacolatoborolanephenyl)‐benzene, and tetrakis(4‐pinacolatoborolanephenyl)methane14b were prepared according to modified literature methods. Other chemicals were commercially available and used without further purification.…”

Section: Methodsmentioning

confidence: 99%

Benzimidazole‐Containing Porous Organic Polymers as Highly Active Heterogeneous Solid‐Base Catalysts

Wang

Liu

et al. 2015

ChemCatChem

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To develop efficient heterogeneous catalytic systems for base‐catalyzed reactions, two benzimidazole‐containing porous organic polymers, BPOP‐1 and BPOP‐2, were synthesized. As a result of the difference in building units, BPOP‐1 exhibits a granular morphology, and BPOP‐2 is composed of tiny particles. N2 adsorption measurements show that BPOP‐1 is a nonporous framework, whereas BPOP‐2 displays good adsorption abilities towards N2, H2, and CO2. Both BPOP‐1 and BPOP‐2 exhibit a higher catalytic activity in the Knoevenagel condensation reaction than their homogeneous molecular counterpart, and the activity of BPOP‐2 is superior to that of BPOP‐1. Theoretical calculations show that the Lewis basicity of the N atoms in BPOP‐1 is identical to that in BPOP‐2. The prominent catalytic performance of BPOP‐2 is mainly attributed to its high specific surface area and microporous character. Moreover, the permanent chemical stability of the structural framework endows BPOP‐2 with an outstanding recyclability.

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Section: Methodsmentioning

confidence: 99%

Benzimidazole‐Containing Porous Organic Polymers as Highly Active Heterogeneous Solid‐Base Catalysts

Wang

Liu

et al. 2015

ChemCatChem

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“…Synthesis of 2-substituted benzimidazoles were also reported by the reaction of o-phenylenediamines or amines with orthoesters using various catalyst such as hexafluoroisopropanol [199], Lewis acids [200], sulfamic acid [201], iodine [202] (Scheme 19). 2-Arylbenzimidazoles have been synthesizing using various methods.…”

Section: -Nitroanilinesmentioning

confidence: 97%

Synthetic Approaches to 2-Arylbenzimidazoles: A Review

Panda

Malik

Jain

2012

COC

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Benzimidazoles are very useful building blocks for the development of molecules that are important in medicinal chemistry. 2-Substituted benzimidazole derivatives have found applications as diverse therapeutic agents, including antiulcers, antihypertensives, antivirals, antifungals, anticancers, and antihistaminics. Because of their importance, the methods for their synthesis have become a focus of Synthetic Organic Chemists. However, we failed to locate report in the literature that covers various efforts that have been made for the synthesis of 2-arylbenzimidazoles. Therefore, in the present review, we have tried to compile some of the important synthetic techniques and methodologies used for its synthesis during the last decade.

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“…The synthesis of benzimidazole compounds has received significant attention because of the broad spectrum of their biological and pharmaceutical properties [87]. The most popular synthesis approaches for these compounds generally involve the condensation of an arylenediamine with a carboxylic acid or its derivative under harsh dehydrating reaction conditions.…”

Section: Synthesis Of Benzimidazole Derivativesmentioning

confidence: 99%