“…Optical sensors based on refractive index (RI) change have become an alternative gas detection tool owing to their handheld capability and room-temperature operation. − As promising candidates, optical fiber-based sensors , and whispering-gallery-mode (WGM) microcavity-based sensors were developed and applied in sensing the surrounding environment. − Specifically, the WGM microcavity is a resonator that can confine light through resonance. − The change of the RI of the surrounding medium influences resonance in the microcavity via the intermediate effect of the evanescent field, and the corresponding shift of the resonant wavelength is engaged as a probe to sense the environmental change. Especially, in the case of rolled-up microtubes, the microring-like cross section also acts as a WGM resonator, , while the subwavelength tube wall leads to an intensified evanescent field in the surrounding environment, and the enhanced coupling from the evanescent field greatly promotes the sensitivity in a large working range. ,,, The wide spectral range and the tubular geometry make it an ideal candidate for on-chip sensing devices, especially in an opto-fluidic system for real-time sensing of a tiny amount of sample .…”