A Higher Ratio of Serum Calcium to Magnesium Is Associated With Aggressive Clinicopathological Characteristics in the Patients Who Underwent Radical Prostatectomy

Kim, Sang Won; Lee, You Jin; Chung, Jong Hak; Ha, Yun‐Sok; Choi, Seock Hwan; Lee, Jun Nyung; Kim, Bum Soo; Kim, Hyun Tae; Kim, Tae‐Hwan; Yoo, Eun Sang; Kwon, Tae Gyun

doi:10.22465/kjuo.2018.16.1.25

Cited by 5 publications

(4 citation statements)

References 29 publications

(24 reference statements)

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“…It was found that none of the studied serum markers (LF, CRP, albumin, LDH, and CRP/ albumin and Ca/Mg) in patients with PC was changed significantly with age, except a slight increase in PSA on a background of a gradual decrease in the Ca/Mg ratio and LF content. This agrees with the data of other authors regarding the slight fluctuations of these indicators in cancer patients of different age groups [8,17,18].…”

Section: Resultssupporting

confidence: 93%

Relationship aggressiveness of prostate cancer with tumor-associated serum markers

Lozovska¹,

Naleskina²,

Zadvorniy³

et al. 2019

Fiziol Zh

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The content of lactoferrin (LF), C-reactive protein (CRP), albumin, lactate dehydrogenase (LDH), as well as Ca/Mg and CRP/albumin ratios in sera of patients with prostate cancer were analyzed in relation to the clinical and pathological features of the disease including the malignancy degree (Gleason score) and the presence of metastases to regional lymph nodes. In the serum of patients with stage III, LF content was lower (1.4 times) and CRP/albumin ratio <0.5 than in patients with stage II, while CRP content and Ca/Mg ratio increased (2.75 and 1.12 times, respectively). In addition, in patients with metastatic lesions of regional lymph nodes, a decrease in LF content (1.3-fold) and level of albumin (1.16-fold) and a simultaneous increase in CRP, Ca/Mg (2.84 and 1.1 times, respectively) and CRP/albumin ratios lower (<0.5) were evident. In serum of patients with tumors of high malignancy degree (8 and 9 points by Gleason score) and prostatespecific antigen (PSA) level exceeding 4 ng/ml, LF content and CRP/albumin ratio decreased whereas CRP content and Ca/Mg ratio were increased, LDH activity in serum of these patients also increased significantly. Therefore, some differences in metabolic pathways in patients with prostate cancer of highly aggressive course have been elucidated. Comparative study of the content of extratumoral serum PC markers (LF, PSA, albumin, LDH, Ca/Mg, CRP/albumin), depending on the clinical manifestations of the tumor process showed that serum LF can be used as an extratumoral marker, which provides new additional information on the features of the clinical course of the disease.

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Section: Resultssupporting

confidence: 93%

Relationship aggressiveness of prostate cancer with tumor-associated serum markers

Lozovska¹,

Naleskina²,

Zadvorniy³

et al. 2019

Fiziol Zh

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“…Attention is drawn to the fact that the LF at a dose of 10 mg/kg changed the Cu/Zn ratio in the BP to a greater extent, whereas in the TT the effect was more pronounced for the Cu/Mg ratio. These data do not contradict the results of studies by other authors who believe that changes in Cu/Mg ratios in TT can be associated with blockages of the epithelial-mesenchymal transition, while Cu/Zn ratio in the BP indicates a change in the activity of some metal-containing antioxidant enzymes [39].…”

Section: Resultssupporting

confidence: 77%

“…It is also noteworthy that the formation of an invasive phenotype of tumor cells in breast cancer is accompanied by an increase of Cu/Mg ratio in the serum of these patients. These changes evidence on activation of the calcium-dependent pathway of the epithelial- mesenchymal transition through transient receptor potential-melastatin-like (TRPM7) [39]. Therefore, we have analyzed the ratio of Cu/Zn and Ca/Mg in BP and TT of animals with Walker-256 carcinosarcoma after treatment with LF (Fig.…”

Section: Resultsmentioning

confidence: 99%

The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma

et al. 2023

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Summary. Aim: To investigate the content of essential elements (EE): copper, zinc, magnesium, iron and calcium and the evaluation of the activity of metal-containing enzymes — ceruloplasmin (CP), myeloperoxidase (MPO) and the content of transferrin (TF) in blood plasma (BP) and tumor tissue (TT) of animals with Walker-256 carcinosarcoma treated with lactoferrin (LF). Materials and Methods: The study of the EE content and the activity of the abovementioned enzymes was carried out on rats with Walker-256 carcinosarcoma treated with LF at the doses of 1 and 10 mg/kg of body weight. The quantitative content of EE in BP and TT of animals was determined using the inductively coupled plasma atomic emission spectroscopy (ICP-AES). Determination of CP activity, content of TF and hemochromes was performed using the method of electron paramagnetic resonance (EPR), and MPO — by unified biochemical method. Results: The introduction of LF at the doses of 1 and 10 mg/kg resulted in a decrease in the ratio of Cu/Zn in BP and even more expressed decrease of Ca/Mg ratio in TT. Administration of LF, especially at a dose of 10 mg/kg, affected the increase in CP and MPO activity in BP. It has been shown that administration of LF at a dose of 10 mg/kg led to an increase in oxidative products of destruction of the hemoglobin-hemochrom system in the TT, against the background of lowering the TF content. Conclusions: The administration of LF, especially at a dose of 10 mg/kg, led to metabolic alterations associated with inhibition of the tumor process. The detected modulating effect of LF on the content of the EE and the activity of the CP and MPO may be a basis for correction of the elemental balance in carcinogenesis.

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“…Inadequate magnesium intake or low serum magnesium concentrations have been related to various diseases and health conditions, including diabetes mellitus, breast cancer, and colorectal cancer. Furthermore, a higher ratio of serum calcium to magnesium has been associated with aggressive clinicopathological characteristics in patients undergoing radical prostatectomy [21] and seen in vitro [22]. It has been hypothesized that alterations in this ratio could lead to the increased development of new and recurrent breast cancer [23].…”

Section: Metal Concentration In Soft Tissuesmentioning

confidence: 99%

Laser-Induced Breakdown Spectroscopy in Biological Samples: A Review of Experiments with Soft Tissues

Manrique,

Garrido,

Velasco

2024

Atoms

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This article reviews the advances made during the past two decades in the application of Laser-Induced Breakdown Spectroscopy (LIBS) to biological samples, specifically soft tissues (both animal and human). The first sections include a historical overview and a summary of the biomedical relevance of analyzing metals in these tissues. Next, statistical methods employed in some works are presented, along with a detailed description of the innovations developed in experimental systems. The remainder of the review reports the approaches used in the experiments, focusing on a description of the advances that have enabled the successful application of LIBS to soft tissues. The results are evaluated, and the major challenges remaining for this type of sample are discussed. The aim of this review is to provide useful information that encourages future research on LIBS for biological samples.

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A Higher Ratio of Serum Calcium to Magnesium Is Associated With Aggressive Clinicopathological Characteristics in the Patients Who Underwent Radical Prostatectomy

Cited by 5 publications

References 29 publications

Relationship aggressiveness of prostate cancer with tumor-associated serum markers

Relationship aggressiveness of prostate cancer with tumor-associated serum markers

The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma

Laser-Induced Breakdown Spectroscopy in Biological Samples: A Review of Experiments with Soft Tissues

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