A higher prevalence of onychomycosis in psoriatics compared with non-psoriatics: a multicentre study

Gupta, Aditya K.; Lynde, Charles; Jain, Hem C.; Sibbald, R. Gary; Elewski, Boni E.; Daniel, C. Ralph; Watteel, G.N.; Summerbell, Richard C.

doi:10.1111/j.1365-2133.1997.tb03673.x

Cited by 126 publications

(74 citation statements)

References 19 publications

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“…In our study positive mycological cultures from nail specimens were obtained in 14 (20.8%) psoriatic patients. The prevalence of onychomycosis caused by yeasts in psoriatic patients is reported as 19-23 % [18,19]. Similarly to the previous report [16], in our study Candida albicans was the commonest isolated fungi in psoriatic patients with nail involvement.…”

Section: Discussionsupporting

confidence: 88%

Prevalence of nail abnormalities in patients with psoriasis

Ovčina-Kurtović¹,

Kasumagić-Halilovic²

2013

Our Dermatol Online

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Introduction: Psoriasis is a chronic inflammatory skin disease that affects about 2% of general population. Clinically, disease can present with cutaneous and nails lesions. Nail abnormalities can be seen in up to two-thirds of patients with psoriasis and both fingernails and toenails may be affected. Objective: The objectives of our study were to evaluate the frequency and clinical presentations of nail abnormalities in patients with psoriasis. Also, we aimed to find correlation between nail changes and some clinical parameters. Methods: One hundred and ten patients with psoriasis were included in this study. A detailed history and examination was recorded for all study subjects, including the age and gender of the patients, type of psoriasis, duration, and extent of disease. Finger and toe nails were clinically examined and nail changes were noted. In the case of clinically suspected of fungal infection, further mycological investigations were performed. Results: Nail abnormalities were present in 67 patients (60.9%) with psoriasis. Nail pitting was the most common lesion observed on fingernails, followed by discoloration of nail plate. Subungual hyperkeratosis of nail plates were significantly more frequent on the toenails. Positive mycological culture was in 14 (20.8%) psoriatic patients with nail involvement. Also, positive correlation between nail abnormalities and duration of psoriasis was found. Conclusions: Nail involvement is common in patients with psoriasis and accompanies skin lesions on the body surface. Pitting and subungual hyperkeratosis are the most frequent nail abnormality in psoriatic patients.

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Section: Discussionsupporting

confidence: 88%

Prevalence of nail abnormalities in patients with psoriasis

Ovčina-Kurtović¹,

Kasumagić-Halilovic²

2013

Our Dermatol Online

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“…[1][2][3] This disease is more common in older age groups and in selected populations, such as swimmers and individuals with diabetes mellitus or psoriasis. [4][5][6] Onychomycosis can be an infection reservoir for dermatomycoses of the adjacent skin, such as interdigital or plantar ("moccasin type") tinea pedis. Studies have shown that onychomycosis can have severe impact on quality of life, 7 and this disease should not be trivialized.…”

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confidence: 99%

Long-term Effectiveness of Treatment With Terbinafine vs Itraconazole in Onychomycosis

Sigurgeirsson¹,

Ólafsson²,

Steinsson³

et al. 2002

Arch Dermatol

189

133

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“…Trichophyton rubrum ließ sich als der bedeutsamste Erreger feststellen [7]. Eine weitere wichtige Risikogruppe stellen Patienten mit Psoriasis dar: In einer Multicenterstudie fand sich eine Onychomykose der Füße bei 13% von 561 Psoriatikern, das Risiko wurde als 56% größer als bei Kontrollpersonen erachtet [16].…”

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Neue Entwicklungen in der medizinischen Mykologie

Körting

Schaller

2001

Der Hautarzt

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Not only have the systemic mycoses clearly increased in number but also mycoses of the skin are more common than presumed in the past. Today onychomycosis is found in up to 10% of human beings. Onychomycosis can compromise quality of life markedly. Common tinea pedis is one of the most important risk factors for erysipelas of the lower legs. The clinical presentation of oral candidosis in HIV-infected patients is changing; Candida dubliniensis has been identified as another important causative microorganism. Onychomycosis today in most cases can be cured using terbinafine or itraconazole. When choosing the ideal drug in a given case, both the benefit risk ratio and the benefit cost ratio have to be taken into account. Liposomally encapsulated amphotericin B represents a major breakthrough in the treatment of systemic mycoses or fever of unknown origin. The same applies to liposomally encapsulated econazole with respect to tinea pedis. In regard to the pathogenesis of Candida infections the family of secreted aspartic proteinases plays a major role as a virulence factor and possible future target for antimycotic treatment.

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A higher prevalence of onychomycosis in psoriatics compared with non-psoriatics: a multicentre study

Cited by 126 publications

References 19 publications

Prevalence of nail abnormalities in patients with psoriasis

Prevalence of nail abnormalities in patients with psoriasis

Long-term Effectiveness of Treatment With Terbinafine vs Itraconazole in Onychomycosis

Neue Entwicklungen in der medizinischen Mykologie

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