Before you lies the result of over 8 months of research conducted at Delft Advanced Reservoir Simulation (DARSim) research group, which concludes my Master's degree in Petroleum engineering. This work was supervised by Dr. H. Hajibeygi, who provided me with a great support and guidance throughout the whole project. I am grateful for the knowledge, energy and inspiration I got from our discussions. In one of the first lectures on Rock Fluid Physics 2 years ago, Hadi said that the person who is practicing (science, research or anything else one finds meaningful) and not afraid to make mistakes along the way, would succeed in his or her endeavours, as well as life. This statement well reflects my intention to take on this challenging project, which eventually granted me opportunities to explore my abilities as a researcher, as well as develop as a professional and a person. This project received contributions from several researchers working on the associated topics. I would like to thank N. Castelletto from Stanford University for fruitful discussions on conceptual method development, which led to a smooth and fast kick-start of this project. I would also like to thank R. Deb from ETH Zurich for cross-checking some of our results. Furthermore, I greatly appreciate the feedback I received from the DARSim group, as well as suggested improvements, which helped to put my work into a broader perspective. Moreover, I would like to thank Dr.Ir. F. van der Meer and Dr.Ir. F. Vossepoel for joining my thesis committee and assessing my work. I owe a special thank you to my colleague M. G. Bastisya for the joint effort of putting together an integrated framework based on our independent Master's research projects, which is beyond the scope of this thesis, nonetheless, has a valuable contribution to knowledge integration. Importantly, a big thank you to my friends and family for support and encouragement, and all the joy that helps to unwind and reenergise after days of coding and debugging. I am proud to present to you the result of our work and I hope you enjoy the read!