A high triglyceride glucose index is more closely associated with hypertension than lipid or glycemic parameters in elderly individuals: a cross-sectional survey from the Reaction Study

Abstract

Background: Both lipid and glucose abnormalities are associated with hypertension (HTN). However, it is unclear whether the triglyceride-glucose (TyG) index is associated with HTN. Therefore the aim of this study is to investigate the association of the TyG index and HTN and to compare the discriminative power of the TyG index, lipid, glycemic parameters for the risk of HTN in elderly individuals. Methods: The present study was nested in a longitudinal (REACTION) study from May 2011 to December 2011, which was designed to demonstrate the association of abnormal glucose metabolism with the risk of cancer in the Chinese population. In total, 47,808 participants were recruited in this cross-sectional study. The TyG index was divided into five groups: the < 20% group, the 20-39% group, the 40-59% group, the 60-79% group and the ≥ 80% group, according to quintile division of the subjects. Three multivariate logistic regression models were used to evaluate the association between the TyG vs. lipid parameters, glycemic parameters and HTN. Results: Multivariate logistic regression analysis shows that compared with lipid and glycemic parameters, the TyG index remains significantly associated with HTN in either total subjects or subjects separated into men and women (odds ratio (OR) 1.33, 95% confidence interval (CI) 1.18-1.51, p < 0.0001 in total subjects; OR 1.39, 95% CI 1.11-1.74, p = 0.0042 in men; OR 1.28, 95% CI 1.11-1.49, p = 0.0010 in women). In a stratified analysis, an elevated TyG index is significantly associated with HTN in the subgroup of the oldest age (≥ 65) (OR 1.67, 95% CI 1.30-2.14, p < 0.0001), as well as with obesity (Body mass index (BMI) ≥ 28 kg/m 2) (OR 1.85, 95% CI 1.29-2.66, p = 0.0009) or lower estimated glomerular filtration rate (eGFR) (< 90 mL/(min•1.73 m 2)) (OR 1.72, 95% CI 1.33-2.21, p < 0.0001). Conclusion: The TyG index is significantly associated with HTN and shows the superior discriminative ability for HTN compared with lipid and glycemic parameters in the Chinese elderly population.

Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea

“…Hypertension is a risk factor for cardiovascular disease. In line with the previous studies [ 44 , 45 ], we noted a trend for a relationship between TyG and hypertension which was significant in women only. Interestingly, Lambrinoudaki et al concluded that TyG could be particularly useful in predicting atherosclerosis in lean and overweight women [ 46 ].…”

The Triglyceride-Glucose Index, an Insulin Resistance Marker, Was Non-linear Associated With All-Cause and Cardiovascular Mortality in the General Population

“…Chiu et al and Zhao et al found that TyG index was associated with macrovascular and microvascular damage ( 30 , 31 ). TyG index was also found to associate with CVD incidence ( 14 , 32 ), hypertension, diabetes, as well as metabolic syndrome ( 11 , 12 , 33 ). Our analyses demonstrated the threshold values to detect mortality risk using TyG index.…”

“…Several speculations have been summarized as follows. First, TyG index had a close relationship with a broad range of adverse health conditions including obesity, diabetes, CVD, higher blood pressure, lower eGFR, and HDL-C levels ( 11 , 12 , 37 ). Elevated TyG index may reflect the adverse effects of impaired cardiometabolic health.…”

Predictive effect of triglyceride‑glucose index on clinical events in patients with type 2 diabetes mellitus and acute myocardial infarction: results from an observational cohort study in China

“…Zhao et al [ 32 ] found that an elevated TyG index was associated with a higher risk of nephric microvascular damage. Zhu et al [ 33 ] showed that an elevated TyG index is signifcantly associated with HT in the subgroup of the lower eGFR(< 90 ml/min/1.73 m 2 ). Maybe we need to do some work on that.…”