A high-throughput system combining microfluidic hydrogel droplets with deep learning for screening the antisolvent-crystallization conditions of active pharmaceutical ingredients

Su, Zhenning; He, Jinxu; Zhou, Peipei; Huang, Lü; Zhou, Jianhua

doi:10.1039/d0lc00153h

Cited by 21 publications

(16 citation statements)

References 37 publications

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“…The researchers obtained homogeneously distributed, small-sized CoQ10-MITO-Porters that were efficiently internalized into cells and accumulated in the mitochondria. Other APIs reportedly produced within microfluidics are ibuprofen [123], lactose [124], aspirin [124], indomethacin [125], danazol [126], cefuroxime axetil [126], piroxicam [127], piracetam [127], carbamazepine [127], and more.…”

Section: Nanomaterials Synthesis Platformsmentioning

confidence: 99%

Fabrication and Applications of Microfluidic Devices: A Review

Niculescu

Chircov

Bîrcă

et al. 2021

IJMS

333

208

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Microfluidics is a relatively newly emerged field based on the combined principles of physics, chemistry, biology, fluid dynamics, microelectronics, and material science. Various materials can be processed into miniaturized chips containing channels and chambers in the microscale range. A diverse repertoire of methods can be chosen to manufacture such platforms of desired size, shape, and geometry. Whether they are used alone or in combination with other devices, microfluidic chips can be employed in nanoparticle preparation, drug encapsulation, delivery, and targeting, cell analysis, diagnosis, and cell culture. This paper presents microfluidic technology in terms of the available platform materials and fabrication techniques, also focusing on the biomedical applications of these remarkable devices.

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Section: Nanomaterials Synthesis Platformsmentioning

confidence: 99%

Fabrication and Applications of Microfluidic Devices: A Review

Niculescu

Chircov

Bîrcă

et al. 2021

IJMS

333

208

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show abstract

“…Antisolvent precipitation or organic displacement crystallization is an energysaving alternative that offers interesting possibilities to better control the crystallization process [9]; this technique is based on changing the solubility of the solute and creating a supersaturated solution by adding a water-miscible organic solvent to force the solute to precipitate [10]. This technique is widely used in the pharmaceutical industry [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Antisolvent Precipitation for Metal Recovery from Citric Acid Solution in Recycling of NMC Cathode Materials

Xuan

Chagnes

Xiao

et al. 2022

Metals

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Lithium-ion batteries (LIBs) are widely used everywhere today, and their recycling is very important. This paper addresses the recovery of metals from NMC111 (LiNi1/3Mn1/3Co1/3O2) cathodic materials by leaching followed by antisolvent precipitation. Ultrasound-assisted leaching of the cathodic material was performed in 1.5 mol L−1 citric acid at 50 °C and at a solid-to-liquid ratio of 20 g/L. Nickel(II), manganese(II) and cobalt(II) were precipitated from the leach liquor as citrates at 25 °C by adding an antisolvent (acetone or ethanol). No lithium(I) precipitation occurred under the experimental conditions, allowing for lithium separation. The precipitation efficiencies of manganese(II), cobalt(II) and nickel(II) decreased according to the order Mn > Co > Ni. The precipitation efficiency increased when a greater volume of antisolvent to the leachate was used. A smaller volume of acetone than ethanol was needed to reach the same precipitation efficiency in accordance with the difference in the dielectric constants of ethanol and acetone and their associated solubility constants. After adding two volumes of acetone into one volume of the leach liquor, 99.7% manganese, 97.0% cobalt and 86.9% nickel were recovered after 120 h, leaving lithium in the liquid phase. The metal citrates were converted into metal oxides by calcination at 900 °C.

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“…The biomedical field is one of the important applications of droplet manipulation technology, including cell culturing, 9,[125][126][127][128] drug synthesis, 129,130 drug delivery, 3,131,132 biochemical analysis, 133 biosensor, 134 clinical diagnosis 135,136 and PCR amplification. [136][137][138][139] Microdroplets that control platforms can enable the control of biochemical and biophysical conditions in cell cultures through precise programmable droplet control.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Bioinspired materials for droplet manipulation: Principles, methods and applications

Xiu

Lian

et al. 2022

Droplet

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Droplet manipulation techniques such as transport and merging have been widely used in many fields including biology, chemistry, material and energy applications. Moreover, droplet manipulation strategies have been extensively investigated and reviewed in terms of droplet placement on solid surfaces. However, less attention has been paid to the practice of droplet manipulation technology in other environments, limiting our understanding and the broadening of technology application. In this article, we provided an overview of the recent progress in controlling droplets in various situations, including droplet manipulation on a surface mediated by the passive strategy (Laplace pressure and wettability gradients) and active strategy (electric field, magnetic field, light and heat). We also presented the principle of droplet manipulation and detailed the application of bionic surfaces in droplet manipulation, and the applications and prospects of droplet manipulation technology were summarized.

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A high-throughput system combining microfluidic hydrogel droplets with deep learning for screening the antisolvent-crystallization conditions of active pharmaceutical ingredients

Abstract: A microfluidic hydrogel droplet platform was combined with deep learning for high-throughput screening of the antisolvent-crystallization conditions of active pharmaceutical ingredients.

Cited by 21 publications

References 37 publications

Fabrication and Applications of Microfluidic Devices: A Review

Fabrication and Applications of Microfluidic Devices: A Review

Antisolvent Precipitation for Metal Recovery from Citric Acid Solution in Recycling of NMC Cathode Materials

Bioinspired materials for droplet manipulation: Principles, methods and applications

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