A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer

Liu, Yang; Zhang, Xiaowei; Zhang, Ping; He, Tingting; Zhang, Weitao; Ma, Dong‐Lai; Li, Ping

doi:10.1016/j.apsb.2023.07.018

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2024

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“…Currently, many basic trials have demonstrated that the specific compounds can directly or indirectly target pyroptosis. These compounds mainly include some common chemotherapy drugs, such as cisplatin, doxorubicin, and 5-FU [ 100 ]. These chemotherapy drugs have been applied in clinical treatment for decades.…”

Section: Introductionmentioning

confidence: 99%

Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases

Liang,

Qin,

et al. 2024

Cell Commun Signal

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Pyroptosis is an active cell death process mediated by gasdermin family proteins including Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME, DFNA5), and DFNB59. Emerging evidences have shown that pyroptosis contributes to many pulmonary diseases, especially lung cancer, and pneumonia. The exact roles of pyroptosis and gasdermin family proteins are tremendously intricate. Besides, there are evidences that pyroptosis contributes to these respiratory diseases. However, it often plays a dual role in these diseases which is a cause for concern and makes it difficult for clinical translation. This review will focus on the multifaceted roles of pyroptosis in respiratory diseases.

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Section: Introductionmentioning

confidence: 99%