2005
DOI: 10.1016/j.jpba.2004.09.038
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A high throughput approach for simultaneous estimation of multiple synthetic trioxane derivatives using sample pooling for pharmacokinetic studies

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Cited by 8 publications
(3 citation statements)
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“…5 Therefore, the ability to rapidly generate the PK properties for a large number of compounds has become very important during lead optimization. Several approaches such as pooling of plasma samples, [6][7][8] truncating PK sample period collection, 9 cassette-accelerated rapid rat screen, 10 snapshot PK, 11 automation of extraction processes, and column switching [12][13][14] have been suggested to increase throughput.…”
Section: Introductionmentioning
confidence: 99%
“…5 Therefore, the ability to rapidly generate the PK properties for a large number of compounds has become very important during lead optimization. Several approaches such as pooling of plasma samples, [6][7][8] truncating PK sample period collection, 9 cassette-accelerated rapid rat screen, 10 snapshot PK, 11 automation of extraction processes, and column switching [12][13][14] have been suggested to increase throughput.…”
Section: Introductionmentioning
confidence: 99%
“…Chromatographic separations were achieved at a flow rate of 1.5 mL/min on a Spheri‐5 ODS Perkin Elmer Brownlee Column (5 µm, 220 × 4.6 mm) with a run time of 15 min. The wavelength was set at 247 nm and the injection volume was 50 μL (Singh et al , ).…”
Section: Methodsmentioning
confidence: 99%
“…CDRI 99/411 ( Fig. 1 ) is a potent orally active 1,2,4-trioxane antimalarial candidate compound for the treatment of malaria [7] , [8] . 1,2,4-Trioxane ring system in artemisinin is essential for the antimalarial activity due to the presence of peroxide group [9] .…”
Section: Introductionmentioning
confidence: 99%