Abstract:CD4+ T cells play a central role in the immune defense against pathogens or tumors but also in immunopathology, such as autoimmunity or allergy. However, due to technical limitations, comprehensive information about the frequency and phenotype of antigen-specific CD4+ T cells against many disease-relevant antigens is missing. In particular the nature of the human naïve repertoire is elusive. We have developed a new, sensitive detection system for antigen-specific T helper cells, based on a combination of magn… Show more
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