A high sensitive SH-SAW biosensor based 36° Y-X black LiTaO3 for label-free detection of Pseudomonas Aeruginosa

Ji, Junkai; Yang, Cheng; Zhang, Feng; Shang, Zhengguo; Xu, Yanhua; Chen, Yu; Chen, Ming; Mu, Xiaojing

doi:10.1016/j.snb.2018.10.128

Cited by 33 publications

(25 citation statements)

References 25 publications

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“…Instead of using a full model, a simplified 3D geometry was built to run the simulations for the sake of avoiding large memory cost and time consumption. FEA through COMSOL Multiphysics ® [25,34,35] was adopted in this research to facilitate computational modeling of the SH-SAW when different cut angles, wave-guide layer materials and thicknesses, and torques are involved. The piezoelectric constitutive equation [36] to be solved is expressed in Equation (3), which couples the mechanical effect as governed by Newton’s law and the electrical effect as determined by Gauss’s law:leftTij=cijklSkl−ekijEkDi=eijkSjk+εijEj, where T ij is the stress matrix, S jk is the strain matrix, E k is the applied electric field, and D i is the electric displacement vector.…”

Section: Simulation Methodologymentioning

confidence: 99%

“…Compared to SAW torque sensors, shear horizontal surface acoustic wave (SH-SAW) [21,22] torque sensors have scarcely been studied. Taking a look at other applications, SH-SAW-based biosensors [23,24,25] and chemical sensors [24,26] are very popular today. Since the wave’s displacement components are parallel to the substrate surface and perpendicular to the propagation direction, little damping of the wave exists in fluid or liquid, and hence, detection sensitivity can be greatly improved.…”

Section: Introductionmentioning

confidence: 99%

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A Three-Dimensional Finite Element Analysis Model for SH-SAW Torque Sensors

Jiang

Chen

Cho

2019

Sensors

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In this paper, a three-dimensional finite element analysis (3D-FEA) model for shear horizontal surface acoustic wave (SH-SAW) torque sensors is presented. Torque sensors play a significant role in various fields to ensure a reliable torque transmission in drivelines. Featuring the advantages of high propagation velocity, large Q-value, and good power capacity, SH-SAW-based torque sensors are promising but very few studies have been carried out. In order to develop a successful sensor, understanding the characteristics of SH-SAWs produced on piezoelectric substrates and torque sensing modes is indispensable. Therefore, in this study, we first investigated the effect on the generation of waves when different Y-cut quartz substrates are engaged. Thereafter, analyses and comparisons regarding the effect on the polarized displacement, wave guidance, and wave mode were conducted for different configurations of wave-guide layer thickness to wavelength ratios (hlayer/λ) and materials. The results showed that Y-cut quartz at an angle close to 36° with a gold (Au) layer varying from hAu/λ = 0.02 to 0.03 thickness could be the most effective configuration for the excitation of SH-SAWs, compared to other combinations using platinum (Pt), titanium (Ti), and silicon dioxide (SiO2). Finally, based on the FEA SH-SAW torque sensor model configured with a Y + 36° quartz substrate and 0.025 λ-thick gold layer, the relationship between the applied torque and sensed voltage was examined, which shows a perfect linearity demonstrating the performance of the sensors.

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Section: Simulation Methodologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Three-Dimensional Finite Element Analysis Model for SH-SAW Torque Sensors

Jiang

Chen

Cho

2019

Sensors

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“…The research in SAW microfluidics is still in its incipient phase, with most of the work focused on fabrication [77,78] and theoretical modeling [79,80]. Notable results are the prototypes for HIV testing [26] and Pseudomonas aeruginosa detection [81]. According to the most recent survey, the trend is towards diagnosis and treatment of infectious diseases [82,83].…”

Section: Current Trends In Microfluidics Researchmentioning

confidence: 99%

Mobile Microfluidics

Alistar

2019

Bioengineering

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Microfluidics platforms can program small amounts of fluids to execute a bio-protocol, and thus, can automate the work of a technician and also integrate a large part of laboratory equipment. Although most microfluidic systems have considerably reduced the size of a laboratory, they are still benchtop units, of a size comparable to a desktop computer. In this paper, we argue that achieving true mobility in microfluidics would revolutionize the domain by making laboratory services accessible during traveling or even in daily situations, such as sport and outdoor activities. We review the existing efforts to achieve mobility in microfluidics, and we discuss the conditions mobile biochips need to satisfy. In particular, we show how we adapted an existing biochip for mobile use, and we present the results when using it during a train ride. Based on these results and our systematic discussion, we identify the challenges that need to be overcome at technical, usability and social levels. In analogy to the history of computing, we make some predictions on the future of mobile biochips. In our vision, mobile biochips will disrupt how people interact with a wide range of healthcare processes, including medical testing and synthesis of on-demand medicine.

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“…SAW biosensors have already been demonstrated in scientific community for a broad range of biosensing purposes such as the detection of specific cells, [ 43–46 ] DNA matching [ 46–49 ] as well as for viral [ 50–53 ] and bacteria [ 54–56 ] detection. Many of these studies had help substantiate the importance of SAW biosensors in the area of biosensing technology amidst the diverse platforms that are available.…”

Section: Introductionmentioning

confidence: 99%

Current Trends on Surface Acoustic Wave Biosensors

Zida

Lin

Khung

2021

Adv Materials Technologies

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The development of rapid biosensing platforms is an integral part for the detection of many diseases, as well as important clinical biomarkers. So far, many new biosensing technologies have been described in literature but many of these novel platforms remain noncommercializable due to challenges in fabrication process, operational conditions as well as other cost concerns. Hence, there is a need to develop efficient and cost‐effective biosensing platforms and of the types available from literature, surface acoustic wave (SAW) biosensors have certain standout attributes. The simple manufacturing requirements of SAW‐based biosensor and its wide operating frequency range have produced promising outcome for bio‐detection and this has rendered this technological platform as a serious contender for point‐of‐care biosensor design. So far, SAW devices are reported for the detection of various bioactive targets of clinical importance and several designs are already commercialized. In this review, the latest development of SAW technologies in recent years for the detection of a broad range of biomolecules is presented and some of the challenges as well as potential future developments of SAW biosensors are highlighted.

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A high sensitive SH-SAW biosensor based 36° Y-X black LiTaO3 for label-free detection of Pseudomonas Aeruginosa

Cited by 33 publications

References 25 publications

A Three-Dimensional Finite Element Analysis Model for SH-SAW Torque Sensors

A Three-Dimensional Finite Element Analysis Model for SH-SAW Torque Sensors

Mobile Microfluidics

Current Trends on Surface Acoustic Wave Biosensors

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