A high‐resolution cross‐species comparative analysis of the subchondral bone provides insight into critical topographical patterns of the osteochondral unit

Michaelis, Jana Christin; Oláh, Tamás; Schrenker, Steffen; Cucchiarini, Magali; Madry, Henning

doi:10.1002/ctm2.745

Cited by 3 publications

(9 citation statements)

References 10 publications

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“…Humans have the largest tibial plateau width (~ 7.4 ± 0.5 cm), followed by sheep (~ 5.1 ± 0.1 cm), minipigs (~ 3.9 ± 0.1 cm), rabbits (~ 1.6 ± 0.1 cm), rats (~ 0.7 ± 0.1 cm), and mice (~ 0.3 ± 0.1 cm). Remarkably, the human subchondral bone plate is considerably thinner (0.52 ± 0.11 mm) than in sheep (1.32 ± 0.14 mm), minipigs (0.82 ± 0.17 mm) and similar to rabbits (0.49 ± 0.05 mm) [ 39 ]. In these animals, the subchondral bone plate is more compact and less porous [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…Remarkably, the human subchondral bone plate is considerably thinner (0.52 ± 0.11 mm) than in sheep (1.32 ± 0.14 mm), minipigs (0.82 ± 0.17 mm) and similar to rabbits (0.49 ± 0.05 mm) [ 39 ]. In these animals, the subchondral bone plate is more compact and less porous [ 39 ]. When normalized to the tibial plateau width, the subchondral bone plate in minipig is twofold, and in sheep and rabbits threefold thicker than in humans [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…In these animals, the subchondral bone plate is more compact and less porous [ 39 ]. When normalized to the tibial plateau width, the subchondral bone plate in minipig is twofold, and in sheep and rabbits threefold thicker than in humans [ 39 ]. Its microstructure (Table 1 ) relates to the severity of OA [ 24 , 26 , 34 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

“…Its microstructure (Table 1 ) relates to the severity of OA [ 24 , 26 , 34 , 40 ]. The subchondral bone plate of rabbits and minipigs is most similar to humans, including similar BS/BV, BS/TV, and closed porosity, while BV/TV is higher, and open and total porosity are lower [ 39 ]. In sheep, BV/TV is higher, and BS/BV, BS/TV, open and total porosity are lower than in humans [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…The subchondral bone plate of rabbits and minipigs is most similar to humans, including similar BS/BV, BS/TV, and closed porosity, while BV/TV is higher, and open and total porosity are lower [ 39 ]. In sheep, BV/TV is higher, and BS/BV, BS/TV, open and total porosity are lower than in humans [ 39 ]. Of note, the specific human topographical pattern of a thinner subchondral bone plate in the region below both menisci is present solely in the larger species (partly in rabbits), but absent in rodents, a clinically highly relevant fact to consider when designing animal studies examining structural (subchondral) consequences of meniscus damage.…”

Section: Introductionmentioning

confidence: 99%

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Subchondral bone remodeling patterns in larger animal models of meniscal injuries inducing knee osteoarthritis – a systematic review

Oláh,

Cucchiarini,

Madry

2023

Knee surg. sports traumatol. arthrosc.

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Purpose Elucidating subchondral bone remodeling in preclinical models of traumatic meniscus injury may address clinically relevant questions about determinants of knee osteoarthritis (OA). Methods Studies on subchondral bone remodeling in larger animal models applying meniscal injuries as standardizing entity were systematically analyzed. Of the identified 5367 papers reporting total or partial meniscectomy, meniscal transection or destabilization, 0.4% (in guinea pigs, rabbits, dogs, minipigs, sheep) remained eligible. Results Only early or mid-term time points were available. Larger joint sizes allow reporting higher topographical details. The most frequently reported parameters were BV/TV (61%), BMD (41%), osteophytes (41%) and subchondral bone plate thickness (39%). Subchondral bone plate microstructure is not comprehensively, subarticular spongiosa microstructure is well characterized. The subarticular spongiosa is altered shortly before the subchondral bone plate. These early changes involve degradation of subarticular trabecular elements, reduction of their number, loss of bone volume and reduced mineralization. Soon thereafter, the previously normal subchondral bone plate becomes thicker. Its porosity first increases, then decreases. Conclusion The specific human topographical pattern of a thinner subchondral bone plate in the region below both menisci is present solely in the larger species (partly in rabbits), but absent in rodents, an important fact to consider when designing animal studies examining subchondral consequences of meniscus damage. Large animal models are capable of providing high topographical detail, suggesting that they may represent suitable study systems reflecting the clinical complexities. For advanced OA, significant gaps of knowledge exist. Future investigations assessing the subchondral bone in a standardized fashion are warranted.

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Section: Introductionmentioning

confidence: 99%