A High Psychological and Somatic Symptom Profile and Family Health Factors Predict New or Persistent Pain During Early Adolescence

Voepel‐Lewis, Terri; Seng, Julia S.; Chen, Bingxin; Scott, Eric L.

doi:10.1097/ajp.0000000000000896

Cited by 6 publications

(14 citation statements)

References 57 publications

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“…Consistent with epidemiological research in adolescent samples, 6,34,41,44,54 we found moderate, positive, and statistically significant correlations between pain, anxiety, and depressive problems among adolescent Italian twins. The aforementioned associations were largely explained by shared genetic and environmental factors influencing a common liability factor.…”

Section: Discussionsupporting

confidence: 90%

Adolescent pain, anxiety, and depressive problems: a twin study of their co-occurrence and the relationship to substance use

Michelini

Francesco

Fagnani

et al. 2021

PAIN

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Data on the etiological factors underlying the co-occurrence of common adolescent pain with anxiety and depression symptoms are very limited. Opioid prescriptions for adolescent pain problems are on the rise in North America and constitute a risk factor for diversion, misuse, and substance use. In this study, we aimed to investigate the phenotypic and etiological association among pain, depression, and anxiety and to test their link to substance use in adolescents. By taking advantage of the Italian National Twin Registry and of the relatively low incidence of opioid prescriptions in Italy, we applied multivariate modelling analyses to 748 Italian adolescent twins (374 pairs, mean age 16 6 1.24 years). Twins' responses to the Achenbach Youth Self-Report questionnaire were used to build a composite adolescent pain index and to measure anxiety, depression, and substance use. All monozygotic withinpair correlations were higher than the dizygotic correlations, indicating genetic influences for adolescent pain, anxiety, and depressive problems. A common latent liability factor influenced by genetic and environmental elements shared among pain, depression, and anxiety provided the best fit to explain the co-occurrence of adolescent pain, anxiety, and depression problems. A common phenotypic factor capturing all 3 phenotypes was positively associated (b 5 0.19, P , 0.001, confidence interval: 0.10-0.27) with substance use. These findings indicate that several intertwined mechanisms, including genetic factors, can explain a shared liability to common adolescent pain, anxiety, and depression problems. Their association with substance use remains traceable even in societies with relatively low prevalence of opioid prescriptions.

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Section: Discussionsupporting

confidence: 90%

Adolescent pain, anxiety, and depressive problems: a twin study of their co-occurrence and the relationship to substance use

Michelini

Francesco

Fagnani

et al. 2021

PAIN

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“…It is possible, given the limitation of the pain survey in the ABCD study and the cross-sectional nature of our analysis, that self-reported pain in our sample was acute rather than persistent or recurrent. We previously found that parental symptoms were related to recurrent or persistent pain from baseline to the first year of follow-up in the preteen ABCD cohort 30. However, pain in that study was derived from parent-reported items in the CBCL survey which reflects frequency of child pain complaints.…”

Section: Discussionmentioning

confidence: 98%

“…Anxiety and depression symptoms are commonly associated with multi-region pain in community-recruited adolescents 5,25. Of concern, limited data suggest that greater or comorbid psychological symptoms among preteens or young adolescents predicts pain persistence in later years 29,30…”

mentioning

confidence: 99%

Biopsychosocial Attributes of Single-region and Multi-region Body Pain During Early Adolescence

Senger-Carpenter¹,

Scott

Isaman³

et al. 2022

The Clinical Journal of Pain

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Objectives: Multi-region pain during adolescence is associated with a higher symptom burden and lower quality of life. The purpose of this study was to describe and compare the biopsychosocial attributes of single-region and multi-region pain among healthy young adolescents. Materials and Methods: We analyzed data from 10,320 children aged 10.6 to 14 years who self-reported pain in the Adolescent Brain and Cognitive Development Study. Pain was coded as single-region or multi-region based on body map data. Results: One in 5 young adolescents indicated recent multi-region pain. Sequential regression supported improved model fit when psychological and sociocultural factors were added to a biological model of pain; however, these models improved the classification of multi-region but not single-region pain. A significant interaction effect of sex and puberty remained constant across models with increased odds of pain at each advancing pubertal stage for both sexes compared with prepuberty, but no difference between girls and boys at late puberty (adjusted odds ratio [OR]=2.45 [1.72, 3.49] and adjusted OR=1.63 [1.20, 2.23], respectively). Psychological factors improved the classification of multi-region pain with significant effects of anxiety, somatic symptoms, and somnolence. Finally, compared with White and non-Hispanic children, Black and Hispanic children were less likely to report pain (adjusted OR=0.70 [0.61, 0.80]; adjusted OR=0.88 [0.78, 0.99], respectively) but had significantly higher pain interference when pain was present (adjusted OR=1.49 [1.29, 1.73] and adjusted OR=1.20 [1.06, 1.35], respectively). Discussion: Pain is a biopsychosocial phenomenon, but psychological and sociocultural features may be more relevant for multi-region compared with single-region pain during early adolescence.

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“…The salience of this is that a systematic review and meta-analysis by Higgins et al 62 showed that there was a greater prevalence of chronic pain in children where either or both parents had chronic pain. A recent longitudinal study of 11,863 children by Voepel-Lewis and colleagues 63 also found that parent symptom burden (which includes the presence of pain) was a significant predictor of child persistent pain at 12 months.…”

Section: The Application Of Family Systems Theory To Pediatric Chroni...mentioning

confidence: 93%

“…Though there may be multiple genetic and/or early neurobiological development factors at play here, 63 , 64 it is also true that a variety of family environment factors may also be contributing to chronic pain chronicity. Family systems theorists in chronic pain 20 have described a chronic pain version of the “family homeostasis” concept previously referred to.…”

Section: The Application Of Family Systems Theory To Pediatric Chroni...mentioning

confidence: 99%

Extending the biopsychosocial conceptualisation of chronic post surgical pain in children and adolescents: The family systems perspective

Newton‐John

2022

Canadian Journal of Pain

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A substantial number of children and adolescents undergoing surgical procedures, as many as 40% in some estimates, will go on to develop chronic postsurgical pain (CPSP). Because of the significant negative impact of CPSP on social and emotional milestones, as well as the child’s quality of life, it is important to identify modifiable factors that are associated with the onset and maintenance of the condition. Research has demonstrated that parent factors can play a role in pediatric chronic pain; however, there has been little examination of parent and family influences on the transition to CPSP. Family systems theories, which consider the influence of the family unit overall on the behavior of individuals members, have been applied to the eating disorders literature for decades. This narrative review proposes a novel application of family systems theory to pediatric CPSP and, in particular, highlights the role that parental dyadic factors may play in the development and maintenance of persistent pain following surgery in children and adolescents.

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A High Psychological and Somatic Symptom Profile and Family Health Factors Predict New or Persistent Pain During Early Adolescence

Cited by 6 publications

References 57 publications

Adolescent pain, anxiety, and depressive problems: a twin study of their co-occurrence and the relationship to substance use

Adolescent pain, anxiety, and depressive problems: a twin study of their co-occurrence and the relationship to substance use

Biopsychosocial Attributes of Single-region and Multi-region Body Pain During Early Adolescence

Extending the biopsychosocial conceptualisation of chronic post surgical pain in children and adolescents: The family systems perspective

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