A high-protein retained PES hemodialysis membrane with tannic acid as a multifunctional modifier

Wei, Qianyu; Feng, Shuman; Zhang, Zezhen; Liu, Lulu; Wu, Lili

doi:10.1016/j.colsurfb.2022.112921

Cited by 9 publications

(5 citation statements)

References 50 publications

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“…An ideal hemodialysis membrane should be able to effectively remove different toxins while preventing the loss of proteins in the blood 62,63 . Here, BSA was used as a model protein, and creatinine and urea were used as model small molecule toxins to conduct solute filtration experiments to evaluate the dialysis performance of the membrane.…”

Section: Resultsmentioning

confidence: 99%

“…38 An ideal hemodialysis membrane should be able to effectively remove different toxins while preventing the loss of proteins in the blood. 62,63 Here, BSA was used as a model protein, and creatinine and urea were used as model small molecule toxins to conduct solute filtration experiments to evaluate the dialysis performance of the membrane. As shown in Figure 7c, the BSA rejection rate of the pure CA membrane was 36.4% ± 1.9%, and after adding PDA@CNCs, the BSA rejection rate of the DCA membrane increased to 49.2% ± 3.8%, which may be related to the reduction of macropores in the membrane structure.…”

Section: Filtration Performance Of Membranementioning

confidence: 99%

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Mixed‐charge cellulose nanocrystal modified cellulose acetate membrane with endotoxin scavenging ability and antibacterial properties

Zhou,

Zhang,

Xia

et al. 2024

J of Applied Polymer Sci

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Blending modification is used to improve the hemocompatibility of cellulose acetate (CA) dialysis membranes while endowing the CA membrane with endotoxin scavenging and antibacterial capabilities. First, polydopamine (PDA) and polyethylenimine (PEI) are used as negatively charged and positively charged moieties, respectively, together with cellulose nanocrystals (CNCs) to construct mixed charge CNCs (PEI‐PDA@CNCs). Then PEI‐PDA@CNCs is blended with the CA casting solution, and the modified CA dialysis membrane is prepared through a phase inversion process. Through biocompatibility, adsorption, antibacterial, and filtration experiments, various properties of PEI‐PDA@CNCs modified CA membrane (PDCA) are systematically tested. The results show that the PDCA membrane exhibited good blood compatibility and noncytotoxicity. At the same time, the PDCA membrane has antibacterial properties and excellent endotoxin adsorption capacity. Compared with the CA membrane, the clearance rates of PDCA membrane for Staphylococcus aureus and Escherichia coli reach 54.0% ± 1.5% and 52.9% ± 5.9% respectively. In the dynamic adsorption experiment, the adsorption capacity of PDCA membrane for endotoxin increases to 2322.1 ± 45.9 EU/g. The research results indicate that PEI‐PDA@CNC‐modified multifunctional CA membrane with endotoxin adsorption and antibacterial properties has potential application prospects in the fields of hemodialysis and blood purification.

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Section: Resultsmentioning

confidence: 99%

Section: Filtration Performance Of Membranementioning

confidence: 99%

Mixed‐charge cellulose nanocrystal modified cellulose acetate membrane with endotoxin scavenging ability and antibacterial properties

Zhou,

Zhang,

Xia

et al. 2024

J of Applied Polymer Sci

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“…Similarly, biocompatible poly(N-acryloyl morpholine) molecules could also be immobilized onto the TA-functionalized PES hollow fiber membrane through hydrogen-bonded layer-by-layer assembly technology [54]. Furthermore, the introduction of a TA layer on the PES membrane significantly contributed to an increase in hydrophilicity, pure water flux, and watersoluble uremic toxin clearance of TA-functionalized PES membranes [51,[55][56][57].…”

Section: Ta-modified Membranesmentioning

confidence: 99%

“…It should be noted that although most TA-functionalized hemodialysis membranes show excellent hemocompatibility, as evidenced by reduced plasma protein adsorption, platelet adhesion, and complement activation in in vitro studies [52, 56], the safety of such membranes has never been tested in in vivo animal experiments or clinical trials. A majority of researchers overlooked the effect of TA leakage from modified hemodialysis membranes, an inherent limitation of TA coating through a mussel-inspired strategy, on the structure and function of blood cells and proteins.…”

Section: State-of-the-art Laboratory Investigations Of Ahmsmentioning

confidence: 99%

“…The results showed that ALA-modified polysulfone membranes not only reduced ROS generation in blood but also significantly improved the hemocompatibility of the resulting membranes, as evidenced by inhibited protein adsorption capacity, platelet adhesion, and activation and prolongation of clotting-activated partial thromboplastin time [67]. In addition, ALA can also collaborate with other antioxidants, such as TA and vitamin E, to prepare hemocompatible hemodialysis membranes with antioxidant properties via either surface modification or blend modification [56, 69, 70]. In conclusion, ALA-modified hemodialysis membranes could be alternative membranes for suppressing hemodialysis-induced oxidative stress and reducing the anticoagulant dose in extracorporeal circuits during hemodialysis sessions in the future.…”

Section: State-of-the-art Laboratory Investigations Of Ahmsmentioning

confidence: 99%

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Alleviation of Oxidative Stress during Hemodialysis Sessions by Hemodialysis Membrane Innovation: A Multidisciplinary Perspective

Li,

Luo,

Yang

et al. 2023

Blood Purif

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Oxidative stress is prevalent in end-stage kidney disease patients receiving chronic hemodialysis and is associated with heavy cardiovascular disease burdens and increased mortality risks. Hemoincompatible hemodialysis membranes per se contribute to the activation of oxidative reactions and the generation of oxygen free radicals. Since the early 1990s, vitamin E-coated membranes have been extensively used in hemodialysis patients to reduce oxidative stress during hemodialysis sessions. However, the beneficial effects of vitamin E-coated membranes versus unmodified synthetic membranes on long-term patient-centered outcomes, such as survival, quality of life, and prevalence of cardiovascular diseases, remain controversial. Accordingly, novel antioxidant hemodialysis membranes were prepared to replace the use of vitamin E-coated membranes despite the translational research on these membranes unfortunately coming to a standstill. In this review, we first summarize the state-of-the-art on the use of vitamin E-coated membranes in hemodialysis patients to highlight their strengths and limitations. Then, we discuss the latest advances in fabricating antioxidant hemodialysis membranes and provide perspectives to bridge knowledge gaps between laboratorial investigations and clinical practice in fabricating antioxidant hemodialysis membranes.

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Advances in Enhancing Hemocompatibility of Hemodialysis Hollow-Fiber Membranes

et al. 2023

Adv. Fiber Mater.

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A high-protein retained PES hemodialysis membrane with tannic acid as a multifunctional modifier

Cited by 9 publications

References 50 publications

Mixed‐charge cellulose nanocrystal modified cellulose acetate membrane with endotoxin scavenging ability and antibacterial properties

Mixed‐charge cellulose nanocrystal modified cellulose acetate membrane with endotoxin scavenging ability and antibacterial properties

Alleviation of Oxidative Stress during Hemodialysis Sessions by Hemodialysis Membrane Innovation: A Multidisciplinary Perspective

Advances in Enhancing Hemocompatibility of Hemodialysis Hollow-Fiber Membranes

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