A high protein low fat meal does not influence glucose and insulin responses in obese individuals with or without type 2 diabetes

Papakonstantinou, Emilia; Triantafillidou, D; Panagiotakos, Demosthenes B.; Iraklianou, Stella; Berdanier, Carolyn D.; Zampelas, Antonis

doi:10.1111/j.1365-277x.2009.01020.x

Cited by 25 publications

(19 citation statements)

References 36 publications

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“…Immediately after the collection of fasting blood samples, all subjects consumed the same standard mixed meal, tested and used in a previous study (Papakonstantinou et al, 2010), in 15-20 min, at the beginning and end of each dietary intervention (for 4 times total; Table 1). …”

Section: Dietsmentioning

confidence: 99%

“…In a previous crossover, randomized study, we compared the effects of two meals containing equal amounts of carbohydrates (50% of total energy), but different protein to fat ratios on postprandial glucose and insulin responses of obese subjects with and without DM2 and reported no significant effects on these variables (Papakonstantinou et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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A high-protein low-fat diet is more effective in improving blood pressure and triglycerides in calorie-restricted obese individuals with newly diagnosed type 2 diabetes

et al. 2010

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Background/Objectives: There is controversy over dietary protein's effects on cardiovascular disease risk factors in diabetic subjects. It is unclear whether observed effects are due to increased protein or reduced carbohydrate content of the consumed diets. The aim of this study was to compare the effects of two diets differing in protein to fat ratios on cardiovascular disease risk factors. Subjects/Methods: A total of 17 obese (body mass index (BMI) ranging from 31 to 45 kg/m 2 ) volunteers with type 2 diabetes (DM2), aged 46 ± 3 years, consumed two diets, each for 4 weeks, with 3 weeks of washout period in a random, blind, crossover design. The diets were: (1) a high-protein low-fat diet (HP-LF, with 30% protein, 50% carbohydrates and 20% fat) and (2) a low-protein high-fat diet (LP-HF, with 15% protein, 50% carbohydrates and 35% fat). Their effects on fasting glycemic control, lipid levels and blood pressure, and on postprandial glucose and insulin responses after a standard test meal at the beginning and end of each dietary intervention were analyzed. Results: Both diets were equally effective in promoting weight loss and fat loss and in improving fasting glycemic control, total cholesterol and low-density lipoprotein (LDL) cholesterol, but the HP-LF diet decreased to a greater extent triglyceride (TG) levels (P ¼ 0.04) when compared with the LP-HF diet. HP-LF diet improved significantly both systolic and diastolic blood pressure when compared with the LP-HF diet (Po0.001 and Po0.001, respectively). No differences were observed in postprandial glucose and insulin responses. Conclusions: A protein to fat ratio of 1.5 in diets significantly improves blood pressure and TG concentrations in obese individuals with DM2.

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Section: Dietsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A high-protein low-fat diet is more effective in improving blood pressure and triglycerides in calorie-restricted obese individuals with newly diagnosed type 2 diabetes

et al. 2010

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“…La evidencia disponible no muestra efectos adversos en sensibilidad a la insulina con una ingesta mayor de CHO, incluso disminuye la resistencia a la insulina siempre que se acompañe de fibra dietaria (9). La ingesta total de energía y el patrón de alimentación saludable se deben priorizar sobre la distribución de macronutrientes (34,35).…”

Section: Conclusiónunclassified

Asociación entre nutrientes y hemoglobina glicosilada en diabéticos tipo 2

Agüero¹,

Godoy²,

Piña³

2016

Nutr Hosp

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Introducción: la hiperglicemia es la característica principal de la diabetes (DM). La restricción de CHO en la dieta presenta el mayor efecto en la disminución de los niveles de glucosa en sangre tanto en DM 1 y 2.Objetivo: asociar la ingesta de macro y micronutrientes con el control metabólico de pacientes con diabetes tipo 2.Material y métodos: se entrevistó a 714 pacientes diabéticos tipo 2 de ambos sexos, entre 27 y 90 años, en centros de salud familiar de Santiago de Chile. Se les aplicó una encuesta alimentaria y una evaluación antropométrica. Se realizó prueba de regresión logística, se estimó además el valor del Odds Ratio (OR) y su correspondiente intervalo de confianza (IC).Resultados: el IMC promedio fue de 30,8 ± 5,7 kg/m2, el 29,8% de los sujetos tenía una HbA1c compensada. Se puede observar que solo la ingesta elevada de carbohidratos (percentil 75) se asoció con un incremento en el riesgo de tener HbA1c elevada OR = 2,7 (IC 95% 1,5-4,8; p < 0,001).Conclusiones: la ingesta elevada de carbohidratos de rápida absorción, altos en sacarosa y bajos en fibra se asocia como factor de riesgo en el incremento de HbA1c. La ingesta total de energía y el patrón de alimentación saludable se debe priorizar sobre la distribución de macronutrientes. Es importante la asesoría de un experto en nutrición especializado en diabetes quien, en colaboración con el equipo médico, debe determinar el tratamiento para cumplir con los objetivos individuales del paciente.

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“…21,22 However, protein does appear to increase the insulin response in people with type 2 diabetes. 21,23,24 There is no clear consensus regarding the effect of protein on blood glucose levels in type 1 diabetes.…”

Section: Do Protein and Fat Play A Role In Hypoglycemia Treatment?mentioning

confidence: 99%

Treatment of Mild Hypoglycemia

Evert¹

2014

Diabetes Spectrum

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A high protein low fat meal does not influence glucose and insulin responses in obese individuals with or without type 2 diabetes

Abstract: Manipulating protein to fat ratio in meals does not affect post-prandial plasma blood glucose or insulin responses in obese people with and without DM2.

Cited by 25 publications

References 36 publications

A high-protein low-fat diet is more effective in improving blood pressure and triglycerides in calorie-restricted obese individuals with newly diagnosed type 2 diabetes

A high-protein low-fat diet is more effective in improving blood pressure and triglycerides in calorie-restricted obese individuals with newly diagnosed type 2 diabetes

Asociación entre nutrientes y hemoglobina glicosilada en diabéticos tipo 2

Treatment of Mild Hypoglycemia

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