A high prevalence of antibody to the hepatitis C virus in patients with hepatocellular carcinoma in Japan

Nishioka, Kusuya; Watanabe, Junnosuke; Furuta, Seiichi; Tanaka, Eiji; Iino, Shiro; Suzuki, Hiroshi; Tsuji, Takao; Yano, Michitami; Kuo, George; Choo, Qui‐Lim; Houghton, Michael; Oda, Tetsuji

doi:10.1002/1097-0142(19910115)67:2<429::aid-cncr2820670218>3.0.co;2-#

Cited by 243 publications

(104 citation statements)

References 16 publications

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“…In addition, we could not determine the hepatitis due to HBV or HCV, although approximately over 80% of liver cancer patients in Japan have antibodies to HCV. 22 Second, history of hepatitis and history of cirrhosis were not investigated in the A town, which led to the exclusion of one third of the study population. However, the HRs adjusted for several factors, including history of these conditions, are not substantially different from those adjusted for age only (Table II).…”

Section: Discussionmentioning

confidence: 99%

Prospective study of vegetable consumption and liver cancer in Japan

Pham¹,

Fujino²,

Ide³

et al. 2006

Intl Journal of Cancer

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We examined the relationship between vegetable consumption and the risk of death from liver cancer in a cohort study in Japan. This analysis is based on data from 6,049 subjects aged 40 to 79 years enrolled in a cohort study conducted in Fukuoka Prefecture, Japan. The follow-up period was from 1986 to 1999. All liver cancer deaths were recorded. The vegetable consumption was classified into 3 groups: ''once per week or less,'' ''2-4 times per week'' and ''daily intake.'' The Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence interval (95% CI). A total of 51 male and 22 female liver cancer deaths were recorded during 62,343 person-years of follow-up. The ''once per week or less'' group was considered the referent group. In males, the multivariate HRs of liver cancer deaths were 0.61 (95% CI: 0.33-1.14) and 0.25 (95% CI: 0.11-0.59) in the ''2-4 times per week'' and ''daily intake'' groups, respectively. In females, the multivariate HRs were 0.44 (95% CI: 0.13-1.51) and 0.51 (95% CI: 0.16-1.69), respectively. The multivariate HRs were also reported by history of hepatitis and cirrhosis. In those without a history of these conditions, the multivariate HRs were 0.54 (95% CI: 0.27-1.09) and 0.36 (95% CI: 0.16-0.83). In those with a history of these conditions, the multivariate HRs were 0.58 (95% CI: 0.22-1.56) and 0.37 (95% CI: 0.13-1.06), respectively. Our study reveals an inverse association between vegetable consumption and the risk of death from liver cancer. These results provide further evidence of the protective effect of vegetables against liver cancer. ' 2006 Wiley-Liss, Inc.Key words: liver cancer; mortality; vegetable; cohort study Liver cancer is one of the malignancies for which the major etiologic factors have been well established. Among these, chronic infection with either hepatitis B virus (HBV) or hepatitis C virus (HCV) has been well documented as a major cause. 1-3 Infection either with HBV or HCV increases the risk of this cancer more than 10-fold. 4 Many other possible etiologic factors, including exposure to excessive alcohol consumption, dietary aflatoxin, diabetes mellitus, cirrhosis of any etiology and others, have been shown to play a role in the development of this cancer. 1,5 A large number of epidemiological studies have been conducted to examine the relationship of high intake of vegetables with a wide range of cancers. 6,7 In 1997, an international review panel (World Cancer Research Fund) 8 reviewed the results of published studies and reported that diets high in vegetables were considered to decrease the risk of most cancer sites. With regard to liver cancer, however, we have identified only a few studies, which examined the association between vegetable consumption and liver cancer, and the results of these were inconsistent. 9-12 To contribute to clarifying this relationship, we conducted this study to investigate the association between vegetable consumption and liver cancer mortality, based on a population-based prospective cohort study in...

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Section: Discussionmentioning

confidence: 99%

Prospective study of vegetable consumption and liver cancer in Japan

Pham¹,

Fujino²,

Ide³

et al. 2006

Intl Journal of Cancer

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“…Hepatitis virus infection, alcohol consumption, and aflatoxin B1 are major factors for hepatocarcinogenesis (Hardell et al, 1984;Nishioka et al, 1991;Feitelson, 1999;Kops et al, 2004). However, mechanism of hepatic carcinogenesis is not well known.…”

Section: Introductionmentioning

confidence: 99%

Mutation analysis of p31comet gene, a negative regulator of Mad2, in human hepatocellular carcinoma

Yun

Kim²,

Park³

et al. 2007

Exp Mol Med

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Failure of mitotic checkpoint machinery leads to the chromosomal missegregation and nuclear endoreduplication, thereby driving the emergence of aneuploidy and tetraploidy population. Although abnormal nuclear ploidy and the resulting impairment of mitotic checkpoint function are typical physiological event leading to human hepatocellular carcinoma, any mutational change of mitotic checkpoint regulators has not yet been discovered. Therefore, we investigated the mutation of p31 comet , a recently identified mitotic checkpoint regulator, in human hepatocellular carcinoma. Of 51 human hepatocellular carcinoma tissue and 6 cell lines tested, five samples exhibited nucleotide sequence variations dispersed on four sites within the entire coding sequence. Among these sites with sequence substitutions, three were found to be missense mutation accompanied with amino acid change but one was a silent mutation. Of these sequence substitutions, two were present in both tumor and non-tumor liver tissues, suggesting the possibility of polymorphism. The present findings indicate that p31 comet does not have an impact on the formation of aneuploidy and tetraploidy found in human hepatocellular carcinoma.

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“…(10) They designated the virus as HCV and devised an assay for serum antibodies to HCV (anti-HCV). (11) Data on the results from the assay demonstrated the high prevalence of anti-HCV among HCC patients, (12,13) and the possible association between HCC and HCV infection has been highlighted.…”

Section: Introductionmentioning

confidence: 99%

A Case-Control Study on the Risk Factors for Hepatocellular Carcinoma in Fukuoka, Japan

Tanaka

Hirohata

1992

Journal of Epidemiology

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We carried out a case-control study of hepatocellular carcinoma (HCC) including 204 patients with HCC and 410 control subjects in Fukuoka prefecture, where HCC risk is among the highest in Japan. The possible risk factors examined were: a) chronic hepatitis B virus (HBV) infection, b) alcohol consumption and cigarette smoking, c) a past history of blood transfusion and hepatitis C virus (HCV) infection. Chronic HBV infection was strongly associated with the development of HCC (relative risk, RR = 14.6). Heavy drinkers experienced about a two-fold risk increase, yet a relationship between cigarette smoking and HCC was not evident. Blood recipients showed a significantly increased RR of 3.0. Serum antibodies to HCV (anti-HCV) were detected by both enzyme-linked immunosorbent assay and recombinant immunoblot assay in 51% of HCCs and 3% of the controls; the RR (and 95% confidence interval) for positive anti-HCV was calculated as 52.3 (23.9-114.3). Among male patients with HCC, the anti-HCV rates were very high in blood recipients (68%), heavy drinkers (62%) and those who had no identifiable risk factors (75%), indicating the possible transmission of HCV via routes other than blood transfusion. We estimated the population attributable risk of HCC at 17% for chronic HBV infection, 13% for heavy drinking, and 49% for HCV infection in Fukuoka. Further investigations are still needed to identify the other infectious routes of HCV besides transfusion.

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A high prevalence of antibody to the hepatitis C virus in patients with hepatocellular carcinoma in Japan

Cited by 243 publications

References 16 publications

Prospective study of vegetable consumption and liver cancer in Japan

Prospective study of vegetable consumption and liver cancer in Japan

Mutation analysis of p31comet gene, a negative regulator of Mad2, in human hepatocellular carcinoma

A Case-Control Study on the Risk Factors for Hepatocellular Carcinoma in Fukuoka, Japan

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