A high-performance silicon micropump for an implantable drug delivery system

Maillefer, D.; Lintel, Harald van; Hirschi, R.

doi:10.1109/memsys.1999.746886

Cited by 82 publications

(40 citation statements)

References 5 publications

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“…Alternative systems for pumping small fluid volumes have been produced over the last three decades [1,2]. Among these various kinds of devices, the reciprocating displacement micropump based on MEMS technology and having two check valves together with a fixed stroke volume has shown the capability to combine both low cost and good performance [3,4].…”

Section: Introductionmentioning

confidence: 99%

Insulin Micropump with Embedded Pressure Sensors for Failure Detection and Delivery of Accurate Monitoring

et al. 2014

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Improved glycemic control with insulin pump therapy in patients with type 1 diabetes mellitus has shown gradual reductions in nephropathy and retinopathy. More recently, the emerging concept of the artificial pancreas, comprising an insulin pump coupled to a continuous glucose meter and a control algorithm, would become the next major breakthrough in diabetes care. The patient safety and the efficiency of the therapy are directly derived from the delivery accuracy of rapid-acting insulin. For this purpose, a specific precision-oriented design of micropump has been built. The device, made of a stack of three silicon wafers, comprises two check valves and a pumping membrane that is actuated against stop limiters by a piezo actuator. Two membranes comprising piezoresistive strain gauges have been implemented to measure the pressure in the pumping chamber and at the outlet of the pump. Their high sensitivity makes possible the monitoring of the pumping accuracy with a tolerance of ±5% for each individual stroke of 200 nL. The capability of these sensors to monitor priming, reservoir overpressure, reservoir emptying, outlet occlusion and valve leakage has also been studied.

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Section: Introductionmentioning

confidence: 99%

Insulin Micropump with Embedded Pressure Sensors for Failure Detection and Delivery of Accurate Monitoring

et al. 2014

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“…In the modern implantable medical electronics fi eld, typical implantable medical applications can be summarized as the following: (1) heart pacemakers [15,18,19] ; (2) implantable defi brillators [20 -22] ; (3) cochlear prostheses [23,24] ; (4) visual prostheses [25,26] ; (5) implantable pain controllers [27,28] ; (6) urinary incontinence prostheses [29,30] ; (7) neural recording microsystems [31 -33] ; (8) implantable measurement microsystems of physiological parameters [3,4,34] , such as pressure, temperature, and bioimpedance; (9) implantable measurement microsystems of biochemical parameters [1,35,36] , such as pH, glucose, and manner of ion concentrations; (10) drug delivery microsystems [11,37] ; and (11) wireless capsule endoscopy [2] . From the elaborate analyses of these typical implantable applications, a general model of IMEDs can be extracted, as illustrated in Figure 5.1 .…”

Section: General Model Of Implantable Medical Electronic Devicesmentioning

confidence: 99%

“…The most common actuator interface in a modern implantable device is the microelectrode, which is applied to stimulate nerves for all kinds of functional prostheses, such as cochlear, visual, and urinary incontinence prostheses. Another typical actuator interface is the microactuator, which can convert electrical energy into mechanical energy to operate micromechanical motors, pumps, or valves that meter delivery from a larger -scale reservoir [37] . Two key factors should be considered in designing the interfaces with living tissue.…”

Section: Interfaces With Living Tissuementioning

confidence: 99%

Design Considerations of Low‐Power Digital Integrated Systems for Implantable Medical Applications

Iniewski

2011

CMOS Biomicrosystems

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“…Piezoelectric materials [1][2][3] which can achieve the conversion between mechanical and electrical energy are widely used in piezoelectric functional devices including sensors, actuators and energy harvesters. Because of the excellent characteristics of the piezoelectric device, it is often used in the field of high technology.…”

Section: Introductionmentioning

confidence: 99%

Study on the interactions between the coatings of electric conductor or dielectric media and piezoelectric substrate in the piezoelectric functional devices

2017

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Because that most of piezoelectric functional devices are combined with the coatings of electric conductor or dielectric media and the piezoelectric substrate, the study on the interactions between them is valuable for their advanced design. In this paper, a method for the electro-mechanical coupling fields in these piezoelectric functional devices is presented. Firstly, the two-dimensional Green’s function for a normal line force or line charge is derived. Then, based on the obtained Green’s function, the interaction mechanism between the coatings of electric conductor or dielectric media and the piezoelectric substrate is studied. Finally, the electro-mechanical coupling fields under arbitrary loads are obtained by superposition principle and Gauss integration. Numerical results show that this method has high computational precision, efficiency and stability. And it can be used to improve the reliability and working performance of the piezoelectric functional device effectively.

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A high-performance silicon micropump for an implantable drug delivery system

Cited by 82 publications

References 5 publications

Insulin Micropump with Embedded Pressure Sensors for Failure Detection and Delivery of Accurate Monitoring

Insulin Micropump with Embedded Pressure Sensors for Failure Detection and Delivery of Accurate Monitoring

Design Considerations of Low‐Power Digital Integrated Systems for Implantable Medical Applications

Study on the interactions between the coatings of electric conductor or dielectric media and piezoelectric substrate in the piezoelectric functional devices

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