A High Omega-3 Fatty Acid Diet Mitigates Murine Pancreatic Precancer Development

Strouch, Matthew J.; Ding, Yongzeng; Salabat, Mohammad R.; Melstrom, Laleh G.; Adrian, Kevin; Quinn, Christopher; Pelham, Carolyn; Rao, Sambasiva; Adrian, Thomas E.; Bentrem, David J.; Grippo, Paul J.

doi:10.1016/j.jss.2009.04.022

Cited by 38 publications

(34 citation statements)

References 25 publications

(20 reference statements)

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“…Tumor-expressed granzyme B degrades ECM components and promotes cancer cell invasion 9. This study is supported by Strouch et al34 who showed that a high ω3-fatty acid diet mitigates murine pancreatic precancer development.…”

Section: Effect Of Docosahexaenoic Acid On Pancreatic Carcinogenesissupporting

confidence: 65%

Anti-cancer Mechanism of Docosahexaenoic Acid in Pancreatic Carcinogenesis: A Mini-review

Park

Kim

2017

J Cancer Prev

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Pancreatic cancer is a highly aggressive malignant tumor of the digestive system and radical resection, which is available to very few patients, might be the only possibility for cure. Since therapeutic choices are limited at the advanced stage, prevention is more important for reducing incidence in high-risk individuals with family history of pancreatic cancer. Epidemiological studies have shown that a high consumption of fish oil or ω3-polyunsaturated fatty acids reduces the risk of pancreatic cancers. Dietary fish oil supplementation has shown to suppress pancreatic cancer development in animal models. Previous experimental studies revealed that several hallmarks of cancer involved in the pathogenesis of pancreatic cancer, such as the resistance to apoptosis, hyper-proliferation with abnormal Wnt/β-catenin signaling, expression of pro-angiogenic growth factors, and invasion. Docosahexaenoic acid (DHA) is a ω3-polyunsaturated fatty acid and rich in cold oceanic fish oil. DHA shows anti-cancer activity by inducing oxidative stress and apoptosis, inhibiting Wnt/β-catenin signaling, and decreasing extracellular matrix degradation and expression of pro-angiogenic factors in pancreatic cancer cells. This review will summarize anti-cancer mechanism of DHA in pancreatic carcinogenesis based on the recent studies.

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Section: Effect Of Docosahexaenoic Acid On Pancreatic Carcinogenesissupporting

confidence: 65%

Anti-cancer Mechanism of Docosahexaenoic Acid in Pancreatic Carcinogenesis: A Mini-review

Park

Kim

2017

J Cancer Prev

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“…A tentative explanation is that the stimulating effect of the n6PUFA-diet was derived from n6PUFAs other than those tested in the present study in vitro. When fish-oil-based n3PUFA diets were used in carcinogen-treated hamsters, pancreatic carcinogenesis was inhibited in some but not all studies [6][7][8]. Although flaxseed-based n3PUFA diets have not been used in pancreatic cancer models, they indeed inhibited non-pancreatic cancers [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…In flaxseed and in fish oil, n-3 polyunsaturated FAs (n3PUFAs) also contribute as principal FAs [1]. Previous studies have shown that increased FAs regulate pancreatic cancer [2][3][4][5][6][7][8]. For instance, diets rich in SFAs and n6PUFAs accelerate the process of pancreatic carcinogenesis in the animal, whereas HFDs made of fish oil and thus rich in n3PUFAs sometimes inhibit the carcinogenetic process [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Four types of fatty acids exert differential impact on pancreatic cancer growth

Yu¹,

Liu²,

Duan³

et al. 2015

Cancer Letters

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“…On the other hand, the existence of an inverse associations between intake of omega-3 FAs and risk of pancreatic cancer was reported in a large population-based case-control study [146] and confirmed in an animal model represented by EL-K-ras mice fed with a high omega-3 FA diet (23 % menhaden oil) compared with age-matched EL-Kras mice fed standard chow (5 % fat). In the first group, the incidence, frequency, and proliferative index of pancreatic pre-cancer EL-Kras mice were reduced compared to the control group [147]. However, a systematic review previously published on the effect of omega-3 FAs on cancer risk in prospective cohort studies, denied the existence of convincing evidence about the association between omega-3 FAs and cancer incidence.…”

Section: Pancreatic Cancermentioning

confidence: 95%

Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials

Nabavi

Bilotto

Russo

et al. 2015

Cancer Metastasis Rev

139

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Over the past decades, extensive studies have addressed the therapeutic effects of omega-3 polyunsaturated fatty acids (omega-3 FAs) against different human diseases such as cardiovascular and neurodegenerative diseases, cancer, etc. A growing body of scientific research shows the pharmacokinetic information and safety of these natural occurring substances. Moreover, during recent years, a plethora of studies has demonstrated that omega-3 FAs possess therapeutic role against certain types of cancer. It is also known that omega-3 FAs can improve efficacy and tolerability of chemotherapy. Previous reports showed that suppression of nuclear factor-κB, activation of AMPK/SIRT1, modulation of cyclooxygenase (COX) activity, and up-regulation of novel anti-inflammatory lipid mediators such as protectins, maresins, and resolvins, are the main mechanisms of antineoplastic effect of omega-3 FAs. In this review, we have collected the available clinical data on the therapeutic role of omega-3 FAs against breast cancer, colorectal cancer, leukemia, gastric cancer, pancreatic cancer, esophageal cancer, prostate cancer, lung cancer, head and neck cancer, as well as cancer cachexia. We also discussed the chemistry, dietary source, and bioavailability of omega-3 FAs, and the potential molecular mechanisms of anticancer and adverse effects.

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A High Omega-3 Fatty Acid Diet Mitigates Murine Pancreatic Precancer Development

Cited by 38 publications

References 25 publications

Anti-cancer Mechanism of Docosahexaenoic Acid in Pancreatic Carcinogenesis: A Mini-review

Anti-cancer Mechanism of Docosahexaenoic Acid in Pancreatic Carcinogenesis: A Mini-review

Four types of fatty acids exert differential impact on pancreatic cancer growth

Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials

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