A High Level of Integrin α6 Expression in Human Intrahepatic Cholangiocarcinoma Cells Is Associated with a Migratory and Invasive Phenotype

Ding, Yanbing; Deng, Bin; Huang, Ying; Xiao, Weiming; Wu, Jian; Zhang, Yanqing; Wang, Yuanzhi; Wu, Dacheng; Lu, Guotao; Wu, Keyan

doi:10.1007/s10620-012-2524-6

Cited by 28 publications

(23 citation statements)

References 27 publications

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“…The α6β4 and α3β1 integrins, which are receptors for laminin, have also been suggested to play key roles in tumor cell invasion and tumor development . Recently, it has been reported that the enhanced expression of integrin α6β4 is associated with a migratory and invasive phenotype and the progression of CCC, whereas almost no expression was detected in most HCC cell lines …”

Section: Introductionmentioning

confidence: 99%

Integrins αvβ6, α6β4 and α3β1 are down‐regulated in cholangiolocellular carcinoma but not cholangiocarcinoma

Soejima

Inoue

Takahashi

et al. 2014

Hepatology Research

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Section: Introductionmentioning

confidence: 99%

Integrins αvβ6, α6β4 and α3β1 are down‐regulated in cholangiolocellular carcinoma but not cholangiocarcinoma

Soejima

Inoue

Takahashi

et al. 2014

Hepatology Research

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“…Increased α6β4 expression found in certain carcinomas also correlates with invasive properties (Gordon et al 2003). 60% of primary breast carcinomas show persistent β4 expression (Davis et al 2001), and α6 levels are high in several tumours (Ding et al 2013;Natali et al 1992). This contrasts with our findings using isogenic progression series, where in fact surface expression of all measured integrins (β1, β4, α6, α2, α5 and αV) decreased with increasing malignancy (Suppl.…”

Section: Integrin Expression and Cell Adhesionmentioning

confidence: 94%

“…One explanation may be that integrin dimers can be redistributed without altering expression. During ageing and fibrosis α6β4, α5β1 and αvβ3 on luminal cells tend to relocate from the basolateral surface to spread into the luminal, lateral and basal surface of the cell (Fig.33) (Ding et al 2013). For example, when hemidesmosomes disassemble following chemotactic stimuli, integrins redistribute to more diffuse F-actin interaction in the plasma membrane (Mercurio et al 2001).…”

Section: Integrin Expression and Cell Adhesionmentioning

confidence: 99%

“…For example, when hemidesmosomes disassemble following chemotactic stimuli, integrins redistribute to more diffuse F-actin interaction in the plasma membrane (Mercurio et al 2001). Increased tissue stiffness is associated with reduced integrin β4 polarity (Paszek et al 2005;Ding et al 2013). The depolarisation and spread of α6β4 throughout the membrane facilitates detachment from the substrate and subsequent migration (Natali et al 1992;Stewart & O'Connor 2015).…”

Section: Integrin Expression and Cell Adhesionmentioning

confidence: 99%

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Microsphere cytometry to interrogate microenvironment-dependent cell signaling

et al. 2017

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2018Avhandling for graden philosophiae doctor (ph.d.)Dato for disputas: 06.04.18Trykk:Skipnes Kommunikasjon / Universitetet i Bergen Materialet i denne publikasjonen er omfattet av åndsverkslovens bestemmelser. Tittel:The effects of ageing on microenvironment-contextual epithelial cell signalling Rein Aasland, for valuable insight on academic writing, and for pointing out, as did James, when my words became self-indulgent fun and flowers. Mark LaBarge, for taking me into his lab, and letting me partake in that which concerns absolutely everyone: ageing. To Martha Stampfer for allowing me to poke around in her human cell resources biobank. To James Garbe for being an incredibly sympathetic guy with the most convenient knowledge up his sleeve.I would like to thank my mother Nina-Mamma for never curbing her enthusiasm for tiny biology when I brought home science homework, and my father Ulf for being genuinely impressed with pretty much everything I didincluding when I did it badly. I need to thank my boyfriend, Lars, for meticulous proofreading of the manuscript, and for continuously encouraging me to put my academic whims into writing. I want to point out that Iren Abrahamsen did substantial preliminary work for the microsphere cytometry method. I need to to thank my medical doctor office mates, Gry and Kjersti for valuable insights from the clinical realm where lab rats never go, to remind me who we're doing this for in the first place. Thanks to Sissel for being that steady rock in the corner stall of the lab where PhDs and postdocs fly by. I would like to thank the girls in the lab for taking up the fight against cancer cell Fråtse-Frida, and winning it. Finally, I would like to thank the Cancer Society, VilVite, CCBIO and Forskningsdagene for giving me trust, whether it was to develop flow cytometry protocols or popular science shows, or to interrogate the microenvironment I would like thank just anyone else in the lab and the general world who is interested and willing to contemplate big ideas such as the purpose of being. And at last, every single nerd: nerdy boys and nerdy girls. pathway activation levels in HMEC are attenuated with age, and that the diminished signaling magnitude in HMEC from ageing women correlated with reduced probability of activating oncogene-induced senescence.Our results suggest that attenuated cell signaling response may reduce the likelihood of activating oncogene induced senescence, for cells in ageing women. We hypothesize this is the result of age-related changes to the microenvironment that support age-emergent cellular phenotypes with increased cancer susceptibility.

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“…Promote the migration and invasion of intrahepatic cholangiocarcinoma [103], pancreatic carcinoma [104], and breast carcinoma [105]; promote invasion of colorectal cancer [106] and squamous cell carcinomas [107] receptor expression [37]. A functional blocking of integrin α5β1 slows tumor growth in VX2 carcinoma, human astrocytoma cells, and human breast cancer [38][39][40].…”

Section: The Role Of Integrins In Cancer Cell Survival and Proliferationmentioning

confidence: 99%

Integrins

Sun

Gao

2014

Anti-Cancer Drugs

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Integrins are a large family of cell surface receptors that bind extracellular matrix proteins. The interaction of integrins with extracellular matrix activates a number of intracellular signaling pathways involved in cell proliferation, differentiation, motility, and other essential cell functions. Integrins are critically important to both health and disease. In this review, we first describe the structure, functions, and signaling characteristics of integrins. We then discuss the roles of integrins in cancer progression. Finally, we recapitulate the laboratory and clinical efforts of targeting integrins as effective means of cancer therapy and diagnosis. This comprehensive review could help scientists and clinicians gain a complete understanding of integrins. It could also contribute toward the development of new drugs, new methods of diagnostics, and new treatment of cancers to benefit the patients in clinical practice.

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A High Level of Integrin α6 Expression in Human Intrahepatic Cholangiocarcinoma Cells Is Associated with a Migratory and Invasive Phenotype

Abstract: Overexpression of integrin α6 is associated with a migratory and invasive phenotype of ICC, and integrin α6 may be used as molecular target for therapy of ICC.

Cited by 28 publications

References 27 publications

Integrins αvβ6, α6β4 and α3β1 are down‐regulated in cholangiolocellular carcinoma but not cholangiocarcinoma

Integrins αvβ6, α6β4 and α3β1 are down‐regulated in cholangiolocellular carcinoma but not cholangiocarcinoma

Microsphere cytometry to interrogate microenvironment-dependent cell signaling

Integrins

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