A high leucine diet mitigates cardiac injury and improves survival after acute myocardial infarction

Witham, William; Yester, Keith; McGaffin, Kenneth R.

doi:10.1016/j.metabol.2012.07.023

Cited by 23 publications

(23 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Oral BCAA supplementation promoted mitochondrial biogenesis of the heart and skeletal muscles through eNOS-derived nitric oxide, decreased ROS in cardiac and skeletal muscles, and prolonged the survival of mice [11]. A leucine diet attenuated myocardial infarction in mice accompanied by a significant increase in cardiac ATP content [17], and leucine and isoleucine improved cardiac systolic function in septic isolated rat heart [48].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Branched-chain amino acids ameliorate heart failure with cardiac cachexia in rats

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Patients with coronary artery disease have a negative protein balance and BCAAs exhibit an anabolic effect on myocardial protein metabolism [16]. Leucine attenuates myocardial infarction in mice [17]. These results show that BCAAs protect the heart from myocardial ischemic injury.…”

Section: Introductionmentioning

confidence: 91%

Branched-chain amino acids ameliorate heart failure with cardiac cachexia in rats

et al. 2015

View full text Add to dashboard Cite

show abstract

“…This study suggests a specific plasma metabolic signature for response to CRT. Responders had higher baseline levels of isoleucine, phenylalanine, leucine, glucose, and valine and lower glutamate, essential for protein synthesis and metabolic signaling 58, 59 . These metabolites may represent a better metabolic reserve and a higher potential for metabolic recovery in CRT responders.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Resynchronization Therapy Induces Adaptive Metabolic Transitions in the Metabolomic Profile of Heart Failure

Nemutlu

Zhang

et al. 2015

Journal of Cardiac Failure

View full text Add to dashboard Cite

Background Heart failure (HF) is associated with ventricular dyssynchrony and energetic inefficiency, which can be alleviated by cardiac resynchronization therapy (CRT). The aim of this study was to determine the metabolomic signature in HF and its prognostic value for the response to CRT. Methods This prospective study consisted of 24 patients undergoing CRT for advanced HF and 10 control patients who underwent catheter ablation for supraventricular arrhythmia but not CRT. Blood samples were collected before and 3 months after CRT. Metabolomic profiling of plasma samples was performed using gas chromatography–mass spectrometry and nuclear magnetic resonance. Results The plasma metabolomic profile was altered in the HF patients, with a distinct panel of metabolites, including Krebs cycle and lipid, amino acid, and nucleotide metabolism. CRT improved the metabolic profile. The succinate/glutamate ratio, an index of Krebs cycle activity, improved from 0.58±0.13 to 2.84±0.60 (P<.05). The glucose/palmitate ratio, an indicator of the balance between glycolytic and fatty acid metabolism, increased from 0.96±0.05 to 1.54±0.09 (P<.01). Compared with the nonresponders to CRT, the responders had a distinct baseline plasma metabolomic profile, including higher isoleucine, phenylalanine, leucine, glucose, and valine levels and lower glutamate levels at baseline (P<.05). Conclusion CRT improves plasma metabolomic profile of HF patients indicating harmonization of myocardial energy substrate metabolism. CRT responders may have a favorable metabolic profile as a potential biomarker for predicting CRT outcome.

show abstract

“…Some data lends credence to hypothesis that some antioxidant and/or anti-inflammatory properties are due to cysteine and leucine, amino acids abundant in whey protein [20,21]. Interestingly, discovery of hydrogen sulfide synthesis from cysteine causing bladder relaxation may be a bit more concretely associated with LUTS [22].…”

Section: Resultsmentioning

confidence: 92%

Dietary Modification of Lower Urinary Tract Symptoms with Fermented Whey Product

Kullisaar¹,

Türk²,

Punab³

et al. 2013

OJU

View full text Add to dashboard Cite

After the age of 50, the prostate begins to increase in size. This is known as benign prostatic hypertrophy (BPH). Compression of urethra by enlarged prostate causes dribbling reduced force of the urinary stream, pain and occasional bleeding or infection. This causes difficulty in urinating and requires many men to get up several times during the night to urinate. The aim of our study was to evaluate an influence of new fermented whey based product (FWP) to several biochemical parameters and lower urinary tract symptoms (LUTS). Patients from the outpatient department of Andrology Center were randomized. This study involved the patients with minor to moderate LUTS, International Prostate Symptoms Score (IPSS) range 3 - 19 but not prostatitis (NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) < 4 and 2-glass test negative for prostate inflammation and infection). Consumption of the FWP decreased the IPSS score in patients with moderate LUTS/BPH (p < 0.001) whereas irritative and obstructive symptoms changed in parallel. There was a correlation between LUTS symptoms change and level of inflammation- and oxidative stress-related indices (blood high-sensitive C-reactive protein, hsCRP; glycated haemoglobin, HbA1c; oxidized low density lipoprotein, oxLDL; interleukine-10, IL-10 and 8-isoprostanes in the urine). Statistically significant changes in mentioned parameters occurred only in study group. Compression of urethra by enlarged prostate explains LUTS in BPH patients. Elevated oxidative stress (OxS) intensifies peroxidation of cell membrane phospholipids. This generates 8-isoprostanes (8-EPI), the prostaglandin-like compounds that can exaggerate LUTS. 8-isoprostanes may cause constriction of bladder and urethra in nanomolar concentrations. Consuming the whey-based product fermented by special lactobacilli strains may improve LUTS as well as OxS and diminish LUTS-related inflammatory response.

show abstract

A high leucine diet mitigates cardiac injury and improves survival after acute myocardial infarction

Cited by 23 publications

References 48 publications

Branched-chain amino acids ameliorate heart failure with cardiac cachexia in rats

Branched-chain amino acids ameliorate heart failure with cardiac cachexia in rats

Cardiac Resynchronization Therapy Induces Adaptive Metabolic Transitions in the Metabolomic Profile of Heart Failure

Dietary Modification of Lower Urinary Tract Symptoms with Fermented Whey Product

Contact Info

Product

Resources

About