A High Fructose Diet Induces Myocardial Oxidative Stress but not Hypertension in Mice

Abstract

device. Despite initial symptomatic improvement, both subsequently developed severe PH within 2 years, one patient being now deceased and the other requiring dual therapy for PH. The remaining patient, a 45-year-old woman with mean PAp of 28 mmHg, PVRI 3.04 m 2 and Qp:Qs of 2.1:1, surprisingly progressed to severe PH and despite therapy is also recently deceased. Conclusion: Transcatheter closure of ASDs in patients with PH may shorten life expectancy, even in the era of novel therapies for PH. Full haemodynamic evaluation of these patients is mandatory and indications for closure should be carefully reviewed.