A high-fish-oil diet prevents adiposity and modulates white adipose tissue inflammation pathways in mice

Enhanced M2 macrophage polarization in high n‐3 polyunsaturated fatty acid transgenic mice fed a high‐fat diet

“…Despite the differences in metabolic phenotypes in hemizygous and homozygous fat‐1 mice, no difference in the degree of macrophage infiltration was observed. This finding is in agreement with several fish oil supplementation studies , suggesting that the metabolic effects of n‐3 PUFAs are, at least in part, a result of inhibition of macrophage infiltration and concomitant cytokine production.…”

Omega-3 Fatty Acid Improve Non Alcoholic Fatty Liver Induced by High Fat Diet in Rats.

“…This in agreement with the previous studies [16,17] ,which reported that omega 3 fatty acid enhanced glucose uptake and improve insulin resistance in HFD-induced NAFLD in rats as omega -3 fatty acid may improve insulin signal transduction in adipocytes, affecting in turn , insulinstimulated glucose transporter (GLUT4) in both skeletal muscule and adipose tissue accompanied with lower glycemia and insulinemia [18] . Moreover, omega-3 fatty acid could regulate both the activity and expression of the liver glucose-6-phosphatase, wich could explain the protective effect with respect to the excessive hepatic glucose output induced by a high fat diet [19].…”

Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

“…Thus targeting the p38 MAPK with its specific inhibitor could be a novel strategy to protect against diabetic associated tissue damage. Bargut et al, [164] have reported that fish-oil diet prevents adiposity and modulates white adipose tissue inflammation through activation of AMPK and inhibition of MAPK and RAS pathways. Metformin, a biguanide agent activates AMPK via inhibition of PKA dependent inhibitory phosphorylation of AMPK [50] and increase in LKB1 mediated AMPK activation [173].…”