A high-fat diet rich in corn oil exaggerates the infarct size and memory impairment in rats with cerebral ischemia and is associated with suppressing osteopontin and Akt, and activating GS3Kβ, iNOS, and NF-κB

Mostafa, Dalia G.; Satti, Huda H.; Khaleel, Eman F.; Badi, Rehab M.

doi:10.1007/s13105-020-00744-2

Cited by 7 publications

(4 citation statements)

References 38 publications

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“…Therefore, under TMP's treatment, inhibiting STAT1 as well as enhancing STAT3 activity is value-oriented for microglial polarization and brain remodeling after stroke. Moreover, GSK3-NFκB signaling axis is vital in microglia-mediated neuroin ammation and tissue repair after cerebral ischemia [57,58]. We found TMP suppressed GSK3β and NFκB p65 activation in the periinfarct cortex of MCAO rats.…”

Section: Discussionmentioning

confidence: 77%

Tetramethylpyrazine promotes remyelination by conversing M1 to M2 polarization of microglia via JAK2-STAT1/3 and GSK3-NFκB signaling pathways in ischemic stroke

Feng

Lin

et al. 2023

Preprint

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Ischemic stroke results in demyelination that underlies neurological disfunction.Promoting oligodendrogenesis will rescue the injured axons and accelerate remyelination after stroke. Microglia react to stroke and polarize to M1/M2 phenotypes. M1 microglia secrete proinflammatory factors to inhibit oligodendrocyte precursor cell (OPC)proliferation and differentiation, inversely, M2 microglia favor the remyelinating process. Tetramethylpyrazine (TMP) has been routinely used in treating cerebrovascular disorders, whereas the role of TMP-mediated microglial polarization on remyelination and the underlying mechanisms remain unknown. In this study, magnetic resonance imaging (MRI) and histopathological evaluation were performed to characterize TMP’s efficacy on remyelinated axon preservation and oligodendrogenesis, particularly, TMP inhibited M1 and enhanced M2 polarization of microglia in cerebral ischemic rats. Moreover, we firstly demonstrated that TMP reversed M1/M2 phenotype via JAK2-STAT1/3 and GSK3-NFκB pathway in lipopolysaccharide (LPS) plus interferon-γ (IFN-γ)-stimulated BV2 microglia. Blocking the crucial target JAK2 will counteract TMP’s effect on mediating M2 polarization of microglia. This study uncovers that TMP’s facilitation on remyelination warrants promising targets for stroke therapy.

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Section: Discussionmentioning

confidence: 77%

Tetramethylpyrazine promotes remyelination by conversing M1 to M2 polarization of microglia via JAK2-STAT1/3 and GSK3-NFκB signaling pathways in ischemic stroke

Feng

Lin

et al. 2023

Preprint

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“…82 A high-fat diet rich in corn oil (CO-HFD) has been associated with significant metabolic abnormalities and reduced memory retention. 83,84 The mentioned diet elevated ROS levels, lipid peroxidation, cytoplasmic cytochrome-c, and cleaved caspase-3 and significantly ameliorated Bcl-2, glutathione (GSH), and SOD in the hippocampus. Moreover, the CO-HFD diet mitigated hippocampal levels of Nrf2, DHA, and RvD1 and significantly enhanced p-NF-κB, p-JNK, p53, p 66 Shc, p-p 66 Shc, and NADPH oxidase.…”

Section: Multiple Sclerosis and Other Demyelinating Diseasesmentioning

confidence: 99%

“…Either inhibition or knockdown of 15‐LOX exhibited a significant decline in the RvD1 content of the prefrontal cortex, blocked the LTP of the hippocampo‐prefrontal cortex pathway, and impaired spatial working memory 82 . A high‐fat diet rich in corn oil (CO‐HFD) has been associated with significant metabolic abnormalities and reduced memory retention 83,84 . The mentioned diet elevated ROS levels, lipid peroxidation, cytoplasmic cytochrome‐c, and cleaved caspase‐3 and significantly ameliorated Bcl‐2, glutathione (GSH), and SOD in the hippocampus.…”

Section: Memory and Cognitionmentioning

confidence: 99%

Resolvin D1: A key endogenous inhibitor of neuroinflammation

2022

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After the initiation of inflammation, a series of processes start to resolve the inflammation. A group of endogenous lipid mediators, namely specialized pro‐resolving lipid mediators is at the top list of inflammation resolution. Resolvin D1 (RvD1), is one of the lipid mediators with significant anti‐inflammatory properties. It is produced from docosahexaenoic acid (omega‐3 polyunsaturated fatty acid) in the body. In this article, we aimed to review the most recent findings concerning the pharmacological effects of RvD1 in the central nervous system with a focus on major neurological diseases and dysfunctions. A literature review of the past studies demonstrated that RvD1 plasma level changes during mania, depression, and Parkinson's disease. Furthermore, RVD1 and its epimer, aspirin‐triggered RvD1 (AT‐RvD1), have significant therapeutic effects on experimental models of ischemic and traumatic brain injuries, memory dysfunction, pain, depression, amyotrophic lateral sclerosis, and Alzheimer's and Parkinson's diseases. Interestingly, the beneficial effects of RvD1 and AT‐RvD1 were mostly induced at nanomolar and micromolar concentrations implying the significant potency of these lipid mediators in treating diseases with inflammation.

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“…According to previous studies, large-artery atherosclerosis was the most common cause of ischemia in middle-aged patients (3,4). Investigations have shown that a high-fat diet (HFD) was accompanied by increased cerebrovascular changes which increased infarct size in the animal model of ischemia (5,6). In addition, based on the report of Hoane et al in the animal model of a cortical contusion injury, HFD caused significantly more excessive loss of cortical tissue (7).…”

Section: Introductionmentioning

confidence: 99%

Decreased Interleukin 6 and Tumor Necrosis Factor α Proteins and Metalloproteinase-2,9 Levels Following Cerebral Ischemia in Cinnamon-treated Rats

Mostajabi,

Tavabi,

Hatami

et al. 2022

Avicenna J Pharm Res

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Background: Metabolic disturbances, including hyperlipidaemia, are risk factors for brain ischemia. Despite all research, no definitive treatment has yet been found for brain ischemia. Thus, this study investigated the effect of cinnamon on ischemic tolerance and the expression of matrix metalloproteinase (MMP) 2 and 9 genes, as well as levels of interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) proteins in rats receiving a high-fat diet (HFD). Methods: Rats were divided into control, sham, model, lovastatin, vehicle, and cinnamon 130 mg (Cin130) and 260 mg (Cin260). All groups, except for the control group, received a high-fat diet for 6 weeks. Then, the last four groups received the corresponding treatment for 6 weeks. The stroke was induced by middle cerebral artery occlusion (MCAO). Twelve hours later, the animals were evaluated for the extent of neurological defects, lipid profiles, tissue damage, and gene expression of MMP-2,9, as well as IL-6 and TNF-α protein level. Results: The results showed that Cin130 has been highly successful in improving neurological defects. Cin130 was effective in reducing serum cholesterol and triglyceride. Further, Cin260 effectively reduced serum LDL. Moreover, Cin130 and Cin260 could reduce tissue damage volume, blood-brain barrier (BBB) integrity, and down-regulation of IL-6, TNF-α proteins and MMP-2,9 levels. Conclusion: Overall, cinnamon, in addition to its lipid-lowering effect, may also have a neuroprotective effect that may be related to the down-regulation of MMPs and cytokines. The two may be independent events or related to a third event; in any case, appropriate experiments should be performed in future studies to determine whether altering the MMPs reduces the effectiveness of cinnamon.

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A high-fat diet rich in corn oil exaggerates the infarct size and memory impairment in rats with cerebral ischemia and is associated with suppressing osteopontin and Akt, and activating GS3Kβ, iNOS, and NF-κB

Cited by 7 publications

References 38 publications

Tetramethylpyrazine promotes remyelination by conversing M1 to M2 polarization of microglia via JAK2-STAT1/3 and GSK3-NFκB signaling pathways in ischemic stroke

Tetramethylpyrazine promotes remyelination by conversing M1 to M2 polarization of microglia via JAK2-STAT1/3 and GSK3-NFκB signaling pathways in ischemic stroke

Resolvin D1: A key endogenous inhibitor of neuroinflammation

Decreased Interleukin 6 and Tumor Necrosis Factor α Proteins and Metalloproteinase-2,9 Levels Following Cerebral Ischemia in Cinnamon-treated Rats

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