A High Fat Diet Inhibits δ-Aminolevulinate Dehydratase and Increases Lipid Peroxidation in Mice (Mus musculus)

Folmer, Vanderlei; Soares, Júlio César Mendes; Gabriel, Diogo; Rocha, João Batista Teixeira da

doi:10.1093/jn/133.7.2165

Cited by 82 publications

(53 citation statements)

References 57 publications

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“…9,10) Of note, in diabetic state the activity of d-ALA-D and the other enzymes of heme pathway are significantly inhibited. 11,12) Consistent with these findings it has been reported that high levels of glucose also produce chemical alterations in other physiologically abundant proteins such as collagen, hemoglobin and albumin. 13,14) Thus, the interest in compounds that could potentially reduce the biological alterations associated with hyperglycemia is intense.…”

supporting

confidence: 68%

Acute Diphenyl Diselenide Treatment Reduces Hyperglycemia But Does Not Change Delta-Aminolevulinate Dehydratase Activity in Alloxan-Induced Diabetes in Rats

Barbosa

Oliveira

Araldi

et al. 2008

Biological & Pharmaceutical Bulletin

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Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in both insulin secretion and/or insulin action. Hyperglycemia, the primary clinical manifestation of diabetes mellitus, is associated with non enzymatic glycation of proteins and free radicals generation.1,2) These processes can cause protein cross-linking and damage in other biomolecules such as enzymes, lipids and DNA; contributing to the overall complications of diabetes mellitus. 3-7)d-Aminolevulinate dehydratase (d-ALA-D) is a sulfhydrylcontaining enzyme, involved in the formation of porphobilinogen, a heme precursor.8) d-ALA-D activity is highly sensitive to the presence of a variety of pro-oxidant agents and to situations associated with oxidative stress, which oxidize its -SH groups.9,10) Of note, in diabetic state the activity of d-ALA-D and the other enzymes of heme pathway are significantly inhibited.11,12) Consistent with these findings it has been reported that high levels of glucose also produce chemical alterations in other physiologically abundant proteins such as collagen, hemoglobin and albumin. 13,14) Thus, the interest in compounds that could potentially reduce the biological alterations associated with hyperglycemia is intense.Selenium is known to be an essential trace element that plays a crucial role as an integral component of several enzymes with antioxidant properties, including glutathione peroxidase. 15,16) Conversely, high doses of selenium can be toxic via its ability to catalyze the oxidation of thiols and to generate free radicals. 10,17) Of particular importance, this element because of its physiological antioxidant properties, exhibits a number of potentially beneficial effects against the development of different diseases 10,[18][19][20] including diabetes mellitus. [21][22][23][24] Moreover, the literature data have indicated that inorganic selenium compounds can attenuate the cytotoxic effects of hyperglycemia via its insulin-mimetic and anti-glycating properties. 25,26) On the other hand, data reported in the literature indicating the therapeutic benefit of synthetic organoselenium compounds in the treatment of diabetes are rare. 24,27,28) Diphenyl diselenide is the simplest of the diaryl diselenides and has glutathione peroxidase-like activity, exhibits antioxidant, hepatoprotective, antiulcer and anti-inflammatory properties.10,29,30) Importantly, a previous study from our research group showed that chronic administration of diphenyl diselenide, at low doses, reduces temporarily the hyperglycemia in streptozotocin-treated (STZ-treated) rats. 23)Thus, the aim of this study was to investigate whether acute treatment with diphenyl diselenide could ameliorate the diabetogenic effects induced by alloxan administration. Thereby, we examined the effect of diphenyl diselenide treatment before and after the diabetes induction, in order to determinate if the compound would act by preventing (pretreatment) and/or restoring (post-treatment) alloxan toxicity. Furthermore, the analy...

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supporting

confidence: 68%

Acute Diphenyl Diselenide Treatment Reduces Hyperglycemia But Does Not Change Delta-Aminolevulinate Dehydratase Activity in Alloxan-Induced Diabetes in Rats

Barbosa

Oliveira

Araldi

et al. 2008

Biological & Pharmaceutical Bulletin

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“…It has been reported that variation in glucose levels, in tandem with other mechanisms, may mediate the sex of an offspring [26][27][28]. Indirect evidence supporting this hypothesis comes from studies showing that female mice fed with a high-fat diet, leading potentially to increased glucose levels [29], produced male-biased litters [30]. There is also increasing interest in hormones as proximate mechanisms of offspring sex ratio variation.…”

Section: Discussionmentioning

confidence: 99%

Can Bovine In Vitro-Matured Oocytes Selectively Process X- or Y-Sorted Sperm Differentially?1

Bermejo-Álvarez¹,

Rizos²,

Rath³

et al. 2008

Biology of Reproduction

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It has been reported that the mammalian female could have a preconceptual influence on the sex of her offspring, and it has been hypothesized that this influence could go some way toward accounting for the reported lower fertility following insemination with sex-sorted sperm. To test whether in vitro matured oocytes are able to select X-or Y-bearing spermatozoa following in vitro fertilization (IVF), we fertilized in vitro 1788 oocytes with Xsorted semen, Y-sorted semen, a mix of X-and Y-sorted semen, and unsorted semen from the same bull, and cultured until Day 9. Fertility was assessed by recording cleavage rate at 48 h postinsemination (hpi) and blastocyst development until Day 9. Embryos were sexed at the two-to four-cell stage and the blastocyst stage. The proportion of zygotes cleaving at 48 hpi was not different between X-and Y-sorted groups and the mix of Xand Y-sorted semen group; however, all were significantly lower than the unsorted group (P , 0.001). Blastocyst yield on Day 6 was significantly higher (P 0.01) in the control group compared with the rest of the groups. Cumulative blastocyst yields on Days 7, 8, and 9 were also significantly higher (P 0.01) in the unsorted group compared with the sorted groups. The proportion of female and male two-to four-cell embryos obtained following IVF with X-and Y-sorted sperm was 88% and 89%, respectively and the sex ratio at the two-to four-cell stage was not different following IVF with unsorted or sorted/recombined sperm (56.9% males vs. 57% males, respectively). At the blastocyst stage, similar percentages were obtained. In conclusion, the differences in cleavage and blastocyst development using sorted versus unsorted sperm are not due to the oocyte preferentially selecting sperm of one sex over another, but are more likely due to spermatic damage caused by the sorting procedure.animal reproduction technology, fertilization, in vitro fertilization, male and female bovine embryos, sex-sorted sperm

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“…This indicates that oxidative phosphorylation is more active, requiring more reducing equivalents (4). Moreover, a fat diet increases the iron absorption and affects its regulation and use (26). This is relevant because iron plays a central role generating free radicals.…”

Section: Discussionmentioning

confidence: 99%

<em>Ilex paraguariensis</em> Extracts Extend the Lifespan of <em>Drosophila melanogaster </em>Fed a High Fat Diet

Colpo¹,

Lima²,

Rosa³

et al. 2017

Preprint

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Studies have suggested that total energy intake and diet composition affect lifespan and ageing. A high-fat diet induces oxidative stress and affects the development of diseases. In contrast, antioxidants are capable of reducing its harmful effects. Yerba mate beverages are an important source of antioxidants, but there is scarce knowledge about their effects on suppressing fat accumulation. Here, we investigated the compounds present in yerba mate extracts and assessed their effects on Drosophila melanogaster given a high cholesterol diet. LS-ESI-MS analysis showed the presence of matesaponins, phenolic compounds and methylxanthines in all of the examined extracts. In Drosophila, under extract treatment conditions, the mean lifespan was significantly extended from 38 to 43 days, there was an increase in the ability to support induced stress and decrease in lipid peroxidation products. Moreover, yerba mate extracts recovered the glutathione S-transferases (GST) activity and reduced the cholesterol level. Taken together, our results support that extracts can extend lifespan by reducing the detrimental effect of a high-fat diet in D. melanogaster, and this outcome can be associated with the compound content in the extracts. This study improves the understanding of natural interventions that reduce stress-induced oxidative damage, which is fundamental in promoting healthy ageing.

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A High Fat Diet Inhibits δ-Aminolevulinate Dehydratase and Increases Lipid Peroxidation in Mice (Mus musculus)

Cited by 82 publications

References 57 publications

Acute Diphenyl Diselenide Treatment Reduces Hyperglycemia But Does Not Change Delta-Aminolevulinate Dehydratase Activity in Alloxan-Induced Diabetes in Rats

Acute Diphenyl Diselenide Treatment Reduces Hyperglycemia But Does Not Change Delta-Aminolevulinate Dehydratase Activity in Alloxan-Induced Diabetes in Rats

Can Bovine In Vitro-Matured Oocytes Selectively Process X- or Y-Sorted Sperm Differentially?1

<em>Ilex paraguariensis</em> Extracts Extend the Lifespan of <em>Drosophila melanogaster </em>Fed a High Fat Diet

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