A high fat diet-induced decrease in hippocampal newly-born neurons of male mice is exacerbated by mild psychological stress using a Communication Box

Murata, Yusuke; Narisawa, Yukiyasu; Shimono, Rima; Ohmori, Hiraku; Mori, Masayoshi; Ohe, Kenji; Mine, Kazunori; Enjoji, Munechika

doi:10.1016/j.jad.2016.11.046

Cited by 21 publications

(16 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, early life stress significantly decreased the number of proliferating cells and neuroblasts in the dentate gyrus [55]. There is a contradictory report indicating that DCX-immunoreactive neuroblasts are similarly observed in control and psychologically stressed mice 7 days after the last stress session while high fat diet-fed ICR mice showed significant decreases in DCX-immunoreactive neuroblasts 7 days after the last stress session compared to high diet-fed control mice [21]. This discrepancy may be associated with the duration and intensity of the electric shocks, and the euthanization time after the last stress session.…”

Section: Discussionmentioning

confidence: 92%

“…Increases in glucocorticoid concentration due to chronic stress exacerbates the degeneration of neurons induced by acute alcohol binging [18], the onset and progression of Alzheimer's disease [19], and Parkinson's disease [20]. Psychological stress does not reduce the number of neuroblasts/immature neurons in the hippocampus of ICR mice although high fat diet-fed mice presented significantly decreased neuroblasts [21]. In contrast, prenatal exposure to psychological stress significantly decreases the proliferating cells in the dorsal hippocampus [22].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Physical Stress Induced Reduction of Proliferating Cells and Differentiated Neuroblasts Is Ameliorated by Fermented Laminaria japonica Extract Treatment

et al. 2020

View full text Add to dashboard Cite

Laminaria japonica is widely cultivated in East Asia, including South Korea. Fucoidan, a main component of L. japonica, protects neurons from neurological disorders such as ischemia and traumatic brain injury. In the present study, we examined the effects of extract from fermented L. japonica on the reduction of proliferating cells and neuroblasts in mice that were physically (with electric food shock) or psychologically (with visual, auditory and olfactory sensation) stressed with the help of a communication box. Vehicle (distilled water) or fermented L. japonica extract (50 mg/kg) were orally administered to the mice once a day for 21 days. On the 19th day of the treatment, physical and psychological stress was induced by foot shock using a communication box and thereafter for three days. Plasma corticosterone levels were significantly increased after exposure to physical stress and decreased Ki67 positive proliferating cells and doublecortin immunoreactive neuroblasts. In addition, western blot analysis demonstrated that physical stress as well as psychological stress decreased the expression levels of brain-derived neurotrophic factor (BDNF) and the number of phosphorylated cAMP response element binding protein (pCREB) positive nuclei in the dentate gyrus. Fermentation of L. japonica extract significantly increased the contents of reduced sugar and phenolic compounds. Supplementation with fermented L. japonica extract significantly ameliorated the increases of plasma corticosterone revels and decline in the proliferating cells, neuroblasts, and expression of BDNF and pCREB in the physically stressed mice. These results indicate that fermented L. japonica extract has positive effects in ameliorating the physical stress induced reduction in neurogenesis by modulating BDNF and pCREB expression in the dentate gyrus.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Physical Stress Induced Reduction of Proliferating Cells and Differentiated Neuroblasts Is Ameliorated by Fermented Laminaria japonica Extract Treatment

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although some literature reveals intact levels of neurogenesis following HFD [75,76], HFD typically disrupts neurogenesis [44,46,77,78]. Yet, such effects are mostly reported after a much shorter period of exposure (i.e., 4-8 weeks) [44,46,77,78], suggesting that decreased neurogenesis might be an initial response to HFD that normalizes over time. This is further supported by studies reporting no changes in the number of proliferating BrdU + cells after 12 weeks of HFD exposure [75] or the number of differentiating DCX + cells after 17 weeks [76] of HFD exposure.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes

et al. 2020

View full text Add to dashboard Cite

Early life stress (ES) increases the risk to develop metabolic and brain disorders in adulthood. Breastfeeding (exclusivity and duration) is associated with improved metabolic and neurocognitive health outcomes, and the physical properties of the dietary lipids may contribute to this. Here, we tested whether early life exposure to dietary lipids mimicking some physical characteristics of breastmilk (i.e., large, phospholipid-coated lipid droplets; Concept Nuturis® infant milk formula (N-IMF)), could protect against ES-induced metabolic and brain abnormalities under standard circumstances, and in response to prolonged Western-style diet (WSD) in adulthood. ES was induced by exposing mice to limited nesting material from postnatal day (P) 2 to P9. From P16 to P42, male offspring were fed a standard IMF (S-IMF) or N-IMF, followed by either standard rodent diet (SD) or WSD until P230. We then assessed body composition development, fat mass, metabolic hormones, hippocampus-dependent cognitive function, and neurogenesis (proliferation and survival). Prolonged WSD resulted in an obesogenic phenotype at P230, which was not modulated by previous ES or N-IMF exposure. Nevertheless, ES and N-IMF modulated the effect of WSD on neurogenesis at P230, without affecting cognitive function, highlighting programming effects of the early life environment on the hippocampal response to later life challenges at a structural level.

show abstract

“…Mice were exposed to intermittent psychological stress, by using the communication box (CBX-9M, Muromachi-Kikai, Tokyo, Japan) that has nine compartments (10 cm × 10 cm) divided transparent plastic walls. Physical stress was given mice through the grid floor by a shock generator (CSG-001, Muromachi-Kikai, Tokyo, Japan) and cycler timer (CBX-CT, Muromachi-Kikai, Tokyo, Japan), as elsewhere reported (Shimoda et al, 2010, Murata et al, 2017). For the repeated physical stress, short duration of electrical foot-shock (0.6 mA, 1 s) was delivered with every 47 s halt (120 times), while for the intermittent physical stress, the same number of shock was delivered randomly, taking 24–96 min.…”

Section: Methodsmentioning

confidence: 99%

LPA1 receptor involvement in fibromyalgia-like pain induced by intermittent psychological stress, empathy

Ueda

Neyama

2017

Neurobiology of Pain

View full text Add to dashboard Cite

Highlights Intermittent psychological stress-induced fibromyalgia-like mouse model. Female-predominant gender difference after the gonadectomy. Pharmacotherapeutical characteristics similar to clinical evidence for fibromyalgia. Complete loss of abnormal pain in lysophosphatidic acid receptor 1 knockout mice. Complete blockade of established pain by repeated treatments of LPA antagonist.

show abstract

A high fat diet-induced decrease in hippocampal newly-born neurons of male mice is exacerbated by mild psychological stress using a Communication Box

Cited by 21 publications

References 77 publications

Physical Stress Induced Reduction of Proliferating Cells and Differentiated Neuroblasts Is Ameliorated by Fermented Laminaria japonica Extract Treatment

Physical Stress Induced Reduction of Proliferating Cells and Differentiated Neuroblasts Is Ameliorated by Fermented Laminaria japonica Extract Treatment

The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes

LPA1 receptor involvement in fibromyalgia-like pain induced by intermittent psychological stress, empathy

Contact Info

Product

Resources

About