A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application

Vuković, Jovana S.; Babić, Marija M.; Antić, Katarina M.; Miljković, Miona G.; Perić-Grujić, Aleksandra A.; Filipović, Jovanka M.; Tomić, Simonida Lj.

doi:10.1016/j.matchemphys.2015.08.022

Cited by 13 publications

(16 citation statements)

References 42 publications

(26 reference statements)

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“…The recorded spectra revealed small shifts of the most characteristic peaks originating from HEA and IA compared to the FTIR spectra of the unloaded analog hydrogels. [45] The following detected shifts indicate the interactions between functional groups of the hydrogels The obtained results show that -OH, -COOH and aliphatic groups were involved in the incorporation of Zn 2+ into the hydrogels.…”

Section: Structural Propertiesmentioning

confidence: 77%

Zn²⁺/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings

Vuković,

Radić1,

Trifunović

et al. 2023

Macro Chemistry & Physics

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Antibacterial hydrogels, as an advanced approach, can create optimal conditions for wound healing, even in the fight against stubborn and difficult‐to‐treat wound infections. Interestingly, pH is an often neglected clinical parameter, although it has a significant impact on the wound healing process. At different stages of wound healing, the pH in the wound bed changes from slightly alkaline to neutral to acidic. To develop novel pH‐sensitive antibacterial hydrogel dressings, Zn2+‐loaded poly(2‐hydroxyethyl acrylate/itaconic acid) hydrogels were synthesized. The hydrogels exhibit pH‐sensitive swelling in the physiologically relevant pH range, with a pronounced swelling ability at neutral pH. The controlled release of Zn2+ occurs in a buffer of pH 7.40 at 37°C. The liquid transport mechanism and release kinetics are evaluated using the specific kinetic models of Ritger‐Peppas and Peppas‐Sahlin. The effect of Zn2+ on structural, thermal, swelling, cytocompatibility, and antibacterial properties is evaluated by Fourier transform infrared spectroscopy, differential scanning calorimetry, swelling studies, MTT, and antibacterial tests. The hydrogels show excellent antibacterial activity against Escherichia coli. The research opens new perspectives for efficient wound healing management, and the extension of the study will be orchestrated by optimising the hydrogel composition to achieve improved performance.This article is protected by copyright. All rights reserved

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Section: Structural Propertiesmentioning

confidence: 77%

Zn²⁺/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings

Vuković,

Radić1,

Trifunović

et al. 2023

Macro Chemistry & Physics

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“…Vukovic et al . prepared a hydrogel based on 2-hydroxyethyl acrylate and different concentrations of itaconic acid.…”

Section: Cunps Embedded In a Matrix: Wound Dressingmentioning

confidence: 99%

“…Lower graphs: Antibacterial activity of the hydrogels against E. coli , C. albicans , and S. aureus (itaconic acid concentration is varied). Reprinted with permission from ref . Copyright 2015 Elsevier.…”

Section: Cunps Embedded In a Matrix: Wound Dressingmentioning

confidence: 99%

“…They are usually biocompatible and suitable for a wide range of medical applications, among which are the smart design of engineered tissues, wound tissues, medicament patches, and contact lenses. 71 Vukovic et al 72 prepared a hydrogel based on 2-hydroxyethyl acrylate and different concentrations of itaconic acid. The dried samples, immersed in a Cu 2+ solution for 24 h, loaded the ions inside the gel.…”

Section: Cunps Embedded In a Matrix: Wound Dressingmentioning

confidence: 99%

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Antimicrobial Nano-Agents: The Copper Age

2021

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The constant advent of major health threats such as antibacterial resistance or highly communicable viruses, together with a declining antimicrobial discovery, urgently requires the exploration of innovative therapeutic approaches. Nowadays, strategies based on metal nanoparticle technology have demonstrated interesting outcomes due to their intrinsic features. In this scenario, there is an emerging and growing interest in copper-based nanoparticles (CuNPs). Indeed, in their pure metallic form, as oxides, or in combination with sulfur, CuNPs have peculiar behaviors that result in effective antimicrobial activity associated with the stimulation of essential body functions. Here, we present a critical review on the state of the art regarding the in vitro and in vivo evaluations of the antimicrobial activity of CuNPs together with absorption, distribution, metabolism, excretion, and toxicity (ADMET) assessments. Considering the potentiality of CuNPs in antimicrobial treatments, within this Review we encounter the need to summarize the behaviors of CuNPs and provide the expected perspectives on their contributions to infectious and communicable disease management.

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“…The P(HEA/IA) hydrogels were synthesized as described in the literature [16,[18][19][20][21][22], with IA mole fractions of 2.0, 5.0, 7.0, and 10.0, respective to monomer. The dimensions of the xerogel disks used in each experiment were 0.450±0.010 cm (average in diameter) and 0.150±0.010 cm (average in thickness).…”

Section: Hydrogel Synthesismentioning

confidence: 99%

Removal of Pb2+ ions from aqueous solution by P(HEA/IA) hydrogels

Antić¹,

Babić²,

Vuković³

et al. 2016

Hem Ind

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A series of poly(2-hydroxyethyl acrylate-co-itaconic acid), P(HEA/IA), hydrogels with different HEA/IA ratio, were synthesized using free radical crosslinking/copolymerization and investigated as sorbents for Pb 2+ from aqueous solutions. Hydrogels were characterized using DMA, FTIR, DSC, SEM and AFM. The adsorption was found to be highly dependent on hydrogel composition, solution pH, sorbent weight, ionic strength and contact time. Five isotherm models, Langmuir, Freundlich, Redlich-Peterson, Temkin and Dubinin-Radushkevich, were applied to the sorption data. The best fit was obtained with Redlich-Peterson isotherm. The separation factor, R L , value indicated favorable sorption for Pb 2+. The maximum sorption capacities were 392.2 and 409.8 mg/g for P(HEA/2IA) and P(HEA/10IA), respectively. Kinetic data showed best fit with pseudo-second-order model. Thermodynamic studies revealed that the reaction was exothermic and proceeds with a decrease in entropy. Moreover, P(HEA/IA) hydrogel showed the most pronounced sorption toward Pb 2+ from environment containing Cu 2+ , Zn 2+ , Cd 2+ , Ni 2+ and Co 2+. Sorption/desorption experiments, showed that the P(HEA/IA) hydrogels could be reused without significant loss of the initial properties even after three adsorption-desorption cycles.

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A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application

Cited by 13 publications

References 42 publications

Zn²⁺/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings

Zn²⁺/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings

Antimicrobial Nano-Agents: The Copper Age

Removal of Pb2+ ions from aqueous solution by P(HEA/IA) hydrogels

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A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application

Cited by 13 publications

References 42 publications

Zn2+/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings

Zn2+/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings

Antimicrobial Nano-Agents: The Copper Age

Removal of Pb2+ ions from aqueous solution by P(HEA/IA) hydrogels

Contact Info

Product

Resources

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Zn²⁺/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings

Zn²⁺/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings