A high dose of short term exogenous d-galactose administration in young male rats produces symptoms simulating the natural aging process

Haider, Saida; Liaquat, Laraib; Shahzad, Sidrah; Sadir, Sadia; Madiha, Syeda; Batool, Zehra; Tabassum, Saiqa; Saleem, Sadia; Naqvi, Fizza; Perveen, Tahira

doi:10.1016/j.lfs.2015.01.016

Cited by 111 publications

(63 citation statements)

References 53 publications

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“…On the other hand, the incidence of anxiety disorder increases in aged people . d ‐gal has been shown to increase anxiety‐like behavior in animals via the overproduction of ROS . We also demonstrated that anxiety‐like behavior increases to some extent in OVX mice treated with d ‐gal.…”

Section: Discussionsupporting

confidence: 56%

Metformin ameliorates the age‐related changes of d‐galactose administration in ovariectomized mice

Fatemi

Heydari

Kaeidi

et al. 2018

Fundamemntal Clinical Pharma

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Metformin (Met) has been shown to have pleiotropic effects such as neuroprotective, antioxidant, and anti-inflammatory properties making that a potential candidate for the treatment of central nervous system (CNS) disorders. This study was designed to investigate the possible effect of Met on the d-galactose (d-gal)-induced aging in ovariectomized mice. The female mice underwent bilateral ovariectomy. d-gal was administered orally at a dose of 500 mg/kg, and Met was administrated orally at doses of 1 and 10 mg/kg for 6 weeks. Anxiety-like behavior was evaluated by the elevated plus-maze. Physical power was assessed by vertical grid holding test and forced swimming capacity test. The brains were assessed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). Ovariectomy caused anxiety and declined the physical power as well as BDNF and SOD levels. d-gal administration in ovariectomized mice exacerbated these deleterious effects. Met hampered the anxiety-like behavior and strengthened the physical power of d-gal-treated ovariectomized mice. Met also increased the SOD and BDNF levels in the brains of d-gal-treated ovariectomized animals. Based on the obtained results, we suggest Met administration as a novel therapeutic approach for the treatment of age-related conditions in the absence of female sex hormones.

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Section: Discussionsupporting

confidence: 56%

Metformin ameliorates the age‐related changes of d‐galactose administration in ovariectomized mice

Fatemi

Heydari

Kaeidi

et al. 2018

Fundamemntal Clinical Pharma

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“…Nowadays, systemic D-gal administration is one of the most extensively used brain aging model building methods [17,18]. Our previous studies have confirmed that rats injected with D-gal for 6 weeks resulted in deterioration of learning and memory capacity and increase of free radicals in the brain [19], which is similar to the performance in natural aging.…”

Section: Discussionmentioning

confidence: 66%

“…D-galactose (D-gal), a reducing sugar, is a naturally occurring metabolic substance in body. At high levels, it can result in the excessive production of oxygen free radicals that damage cellular lipids, proteins, and DNA, which eventually impairs normal function of macromolecules and cells [17]. It has been shown that prolonged systemic exposure of rodents to D-gal makes oxidative stress increase and anti-oxidation function decline, which causes brain cell biological membrane peroxide reaction, and finally results in degenerative changes of brain [17,18].…”

Section: Introductionmentioning

confidence: 99%

Aerobic exercise ameliorates learning and memory deficits of aging rats induced by D-galactose via promoting SYP and BNDF expression in hippocampus

Zhang

Yuan

2017

BIO Web Conf.

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Abstract. The aim of this study was to explore the effects of aerobic exercise on learning and memory of aging brain and the underlying potential mechanism. We adopted the method of intraperitoneal administration for 6 weeks to induce aging rat model and gave rats swimming exercise intervention in the process of aging modeling. Then the Morris Water Maze test, immunofluorescence, western blotting and real time PCR technology were adopted to estimate rats' learning and memory abilities and the expression levels of BDNF and SYP in hippocampus respectively. Compared with the aging model rats induced by D-gal administration, the rats subjected to swimming exercise in the process of aging modeling showed not only faster acquisition and better retention of the maze but also higher expression levels of BDNF and SYP in hippocampus. These findings provide evidence that aerobic exercise could ameliorate learning and memory deficits of aging rats induced by D-gal, which is related to aerobic exercise' promoting hippocampal BNDF and SYP expression.

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“…Forced swim test (FST) Depressive behavior was tested in a glass tank (56 cm height and 30 cm width) using an established method for quantifying depression responses in rats Elevated plus maze (EPM); Morris water maze (MWM); Novel object recognition (NOR). (Haider et al, 2015). The apparatus was filled with water to a height of 22-24 cm so that the rat was forced to swim but could not escape the surface of the water.…”

Section: Behavioral Analysismentioning

confidence: 99%

“…In the present study, the apparatus was used to assess aversive memory based on the idea that the rat feels fear from elevation in the open area. Upon repeated testing, the rat acquires information regarding the maze area and recalls the places where it feels safe (Haider et al, 2015). The test was comprised of two sessions.…”

Section: Elevated Plus Maze (Epm)mentioning

confidence: 99%

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts

Batool¹,

Agha²,

Tabassum³

et al. 2019

Acta Neurobiologiae Experimentalis

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Cadmium, a heavy metal with no physiological function in the human body, is considered a bio-hazard. It is also considered to be a potent neurotoxin. The primary sources of cadmium exposure are diet and cigarette smoke. It has been postulated that nutritional deficiencies can increase the risk of cadmium toxicity. Nuts provide essential nutrients which are necessary for the maintenance of brain health in humans. The present study was designed to investigate the possible protective effects of almond and walnut supplementation on cadmium-induced neurotoxicity. Cadmium was orally administered at a dose of 50 mg/kg weekly with or without the supplementation of almond and walnut in rats. Intensities of depression-and anxiety-related behaviors were assessed by the forced swim test and light/dark transition test, respectively. Memory function was also evaluated by the elevated plus maze, Morris water maze and novel object recognition task. After four weeks of treatment it was observed that cadmium administration significantly induced depressogenic and anxiogenic behaviors. Memory function was also impaired by cadmium administration. Cadmium-treated rats exhibited reduced noradrenalin, dopamine and serotonin levels in the brain, whereas the levels of their respective metabolites were significantly increased. The dietary supplementation of almond and walnut at a dose of 400 mg/kg/day significantly attenuated cadmium-induced depression, anxiety and memory impairments. Neurochemical aberrations also normalized following supplementation with these nuts in rats. The present study demonstrates that long-term supplementation with almond and walnut provides essential nutrients which may overcome nutritional deficiencies and thereby reduce heavy-metal intoxication.

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A high dose of short term exogenous d-galactose administration in young male rats produces symptoms simulating the natural aging process

Cited by 111 publications

References 53 publications

Metformin ameliorates the age‐related changes of d‐galactose administration in ovariectomized mice

Metformin ameliorates the age‐related changes of d‐galactose administration in ovariectomized mice

Aerobic exercise ameliorates learning and memory deficits of aging rats induced by D-galactose via promoting SYP and BNDF expression in hippocampus

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts

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