A high affinity monoclonal antibody against HLA-E-VL9 enhances natural killer cell anti-tumor killing
Joyce K. Hwang,
Daniel J. Marston,
Daniel Wrapp
et al.
Abstract:Natural killer (NK) cells kill target cells following triggering via germline-encoded receptors interacting with target cell-expressed ligands (direct killing), or via antibody-dependent cellular cytotoxicity (ADCC) mediated by FcγRIIIa. NK cytotoxicity is modulated by signaling through activating or inhibitory receptors. A major checkpoint is mediated by the NK inhibitory receptor NKG2A/CD94 and its target cell ligand, HLA-E, which is complexed with HLA signal sequence-derived peptides termed VL9 (HLA-E-VL9).… Show more
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