A hierarchical approach to mutagenicity testing and regulatory control of environmental chemicals

Bora, K. C.

doi:10.1016/0027-5107(76)90076-2

Cited by 14 publications

(2 citation statements)

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“…A major achievement has been the introduction of techniques for the rapid identifi cation of mutagenic or carcinogenic potential, and a number of excellent monographs or reviews have dealt with this subject (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). General agreement now appears to exist that a battery of tests is required for toxicological evaluations in mass screening programs (14)(15)(16)(17)(18)(19). Over 100 short-term tests for detecting poten tial chemical carcinogens and mutagens are available (9), and the critical issue in developing a battery of tests is to formulate appropriate criteria for selecting a battery of tests.…”

Section: Introductionmentioning

confidence: 99%

Systematic Carcinogen Testing Through the Decision Point Approach

Williams¹,

Weisburger²

1981

Annu. Rev. Pharmacol. Toxicol.

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Section: Introductionmentioning

confidence: 99%

Systematic Carcinogen Testing Through the Decision Point Approach

Williams¹,

Weisburger²

1981

Annu. Rev. Pharmacol. Toxicol.

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“…Bora, 1976;Bridges, 1976;Brusick, 1978;Connor et al, 1979;Dean, 1976;Fishbein, 1979]. They all consider vital aspects of the problem of risk-benefit assessment and additionally also rank compounds ac cording to structure, volume of production, potential usage, exposure level, propulation, social and economic benefit.…”

Section: Prescreening Compounds For Long-term Carcino Genicity Experimentioning

confidence: 99%

Mutagenicity – Relevance of Short-Term Tests

Pool¹

1980

Oncology

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Short-term tests measuring diverse biological activities of compounds, such as mutagenicity, have been proposed as prescreening methods to determine potential carcinogenicity. High correlations of up to 90% have been found for response in short-term testis versus response in long-term carcinogenicity assays, e.g. for the Salmonella-microsome method developed by Ames and also for the cell transformation test developed by Styles. How these short-term assays may be suited to predict potential carcinogenicity of N-nitrosamines is described. Data on how the mutagenicity of N-nitrosamines in the Salmonella-microsome assay compares to their carcinogenicity shows that correlation factors as high as 90% have not necessarily been obtained. The reasons for this apparent lack of correlation as well as which valuable role the short-term assays play in other fields of chemical carcinogenesis is discussed.

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The High Production Volume Chemical Challenge Program: The Relevance of the in Vivo Micronucleus Assay

Rosenkranz

Cunningham

2000

Regulatory Toxicology and Pharmacology

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A hierarchical approach to mutagenicity testing and regulatory control of environmental chemicals

Cited by 14 publications

References 1 publication

Systematic Carcinogen Testing Through the Decision Point Approach

Systematic Carcinogen Testing Through the Decision Point Approach

Mutagenicity – Relevance of Short-Term Tests

The High Production Volume Chemical Challenge Program: The Relevance of the in Vivo Micronucleus Assay

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