A hexagonal solvate of the neurotransmitter γ-aminobutyric acid

Anomalous Temperature Dependence of the Lowest-Frequency Lattice Vibration in Crystalline γ-Aminobutyric Acid

“…GABA has been reported in two distinct polymorphic forms, monoclinic and tetragonal, as well as a hexagonal ethanol-solvated cocrystal. − SC-XRD was performed on GABA (Alfa Aesar, 97%, lot: K12Z010) recrystallized from aqueous solution to ensure and verify the presence of the monoclinic form. The structure solved in the present work at 95 K was consistent with the monoclinic results published by Steward et al In addition to the complete structure determination at 95 K, the unit cell dimensions of monoclinic GABA were measured over a range of temperatures from 290 to 100 K. Measurements were obtained using a Bruker KAPPA APEX DUO diffractometer with an APEX II CCD and Mo Kα radiation (λ = 0.710 73 Å) for full structure determination, while the temperature-dependent measurements were collected using Cu Kα radiation (λ = 1.5418 Å).…”

Are gamma amino acids promising tools of crystal engineering? – Multicomponent crystals of baclofen

“…The main packing motif in the crystal is the hydrogen bonded 2D net of molecules in an off-set brick type arrangement (Fig. 8), and this feature may be described by the R 5 6 (32) ring formed from pairs of N1-H11A⋯O3, N1-H11C⋯O4 and O2-H9⋯O4 hydrogen bonds. It is interesting to note that this packing significantly differs from other maleate salts of amino acids recently discussed.…”

“…Undoubtedly, the most typical γ-AA is the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Its solvate formation properties 5 and hydrate formation under high pressure 6 have been investigated recently. Gabapentin is a structural analogue of GABA and a widely marketed drug under various brand names to treat pain, epilepsy and bipolar disorder.…”

Guest diffusion in dipeptide crystals

“…However its microporous behaviour upon removal of the solvent guest was not yet confirmed. 11 In the case of Leu-Ser, there is a complete loss of cocrystallized solvent (acetonitrile) and re-uptake of an inorganic molecule (I 2 ) with full retention of the supramolecular host network (peptide). 10…”