A HEV ORF2 protein-mediated mechanism of hepatitis E-associated kidney disease
Birgit Helmchen,
Anne-Laure Leblond,
Daniela Lenggenhager
et al.
Abstract:Hepatitis E virus (HEV) infection, one of the most common forms of hepatitis worldwide, is often associated with extrahepatic, particularly renal, manifestations. However, the underlying mechanisms are incompletely understood. Here, we report the development of de novo immune complex-mediated glomerulonephritis (GN) in a kidney transplant recipient with chronic hepatitis E. Applying immunostaining, electron microscopy, and mass spectrometry after laser-capture microdissection, we show that GN developed in para… Show more
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