A heparin-functionalized covered stent prepared by plasma technology

Zhu, Quing; Guo, Fang; Zhu, Yimen; Nan, Wenbin; Chang, Zhaohua

doi:10.1177/08853282211051871

Cited by 3 publications

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can be administered intravenously or through a skin injection. Its anticoagulant properties are also used in kidney dialysis machines and blood specimen test tubes [66]. Bleeding, pain at the injection site, and low blood platelets are typical side effects.…”

Section: Heparin-based Coatingsmentioning

confidence: 99%

Coatings for Cardiovascular Stents—An Up-to-Date Review

Udriște,

Burdușel,

Niculescu

et al. 2024

IJMS

View full text Add to dashboard Cite

Cardiovascular diseases (CVDs) increasingly burden health systems and patients worldwide, necessitating the improved awareness of current treatment possibilities and the development of more efficient therapeutic strategies. When plaque deposits narrow the arteries, the standard of care implies the insertion of a stent at the lesion site. The most promising development in cardiovascular stents has been the release of medications from these stents. However, the use of drug-eluting stents (DESs) is still challenged by in-stent restenosis occurrence. DESs’ long-term clinical success depends on several parameters, including the degradability of the polymers, drug release profiles, stent platforms, coating polymers, and the metals and their alloys that are employed as metal frames in the stents. Thus, it is critical to investigate new approaches to optimize the most suitable DESs to solve problems with the inflammatory response, delayed endothelialization, and sub-acute stent thrombosis. As certain advancements have been reported in the literature, this review aims to present the latest updates in the coatings field for cardiovascular stents. Specifically, there are described various organic (e.g., synthetic and natural polymer-based coatings, stents coated directly with drugs, and coatings containing endothelial cells) and inorganic (e.g., metallic and nonmetallic materials) stent coating options, aiming to create an updated framework that would serve as an inception point for future research.

show abstract

Section: Heparin-based Coatingsmentioning

confidence: 99%

Coatings for Cardiovascular Stents—An Up-to-Date Review

Udriște,

Burdușel,

Niculescu

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Woven polyester vascular stent-grafts with surface modification of chitosan/heparin

Wang,

Li,

Zhang

et al. 2024

J Mater Sci

View full text Add to dashboard Cite

Design and fabrication of silicone-silica nanocomposites airway stent

Morad Hasely,

Farahani,

Baniassadi

et al. 2023

Front. Mater.

View full text Add to dashboard Cite

Introduction: Due to the COVID-19 pandemic in recent years, many patients after extubation had stenosis in all tracheal areas because of long-term intubation. Therefore, tracheal stenosis in these patients is benign and can be treated using silicone stents, and many patients need silicone stents during recovery. A silicone stent is an artificial support that plays a significant role in managing airway obstruction.Methods: This research aims to fabricate an optimal silicone stent reinforced with Nanosilica by vacuumed injection molding. Materials-based nanocomposites are made of rtv2 silicone with 1wt%, 3wt%, and 5wt% of hydrophilic and hydrophobic Nanosilica particles. Hardness, tensile, and hydrophobicity properties have been performed for the experimental characterization of the nanocomposites.Results and Discussion: The uniform distribution of nanoparticles in the silicone matrix has been confirmed using SEM images. Adding Nano-silica increases hardness and tensile strength and improves the silicone matrix’s mechanical properties. Also, the addition of nanoparticles changes the surface hydrophobicity properties and roughness. Although the presence of nanoparticles improves the mechanical properties, it also reduces the transparency and increases the viscosity. Our results show that adding 1wt%. Hydrophobic Nano-silica improves nanocomposites’ mechanical properties and preserves transparency and viscosity (mold-ability) for stent construction. Adding 3wt%. Hydrophilic Nano-silica improves mechanical and hydrophobic properties, but moldability is not easy. Finally, the fabricated nanocomposite airway stents were successfully placed on the sheep trachea in the pilot animal study.

show abstract

A heparin-functionalized covered stent prepared by plasma technology

Cited by 3 publications

References 34 publications

Coatings for Cardiovascular Stents—An Up-to-Date Review

Coatings for Cardiovascular Stents—An Up-to-Date Review

Woven polyester vascular stent-grafts with surface modification of chitosan/heparin

Design and fabrication of silicone-silica nanocomposites airway stent

Contact Info

Product

Resources

About