A hematologist's view of unexplained iron deficiency anemia in males: Impact of Helicobacter pylori eradication

Hershko, Chaim; Ianculovich, Mara; Souroujon, Moshe

doi:10.1016/j.bcmd.2006.09.006

Cited by 45 publications

(31 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Six open studies have observed improvements in anaemia and Fe status associated with H. pylori eradication (30)(31)(32)(33)(34)(35) . A randomized controlled trial did suggest a role for H. pylori in causing anaemia among adolescents, but only included small numbers of subjects (36) .…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pyloriis not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela

Santos

Boccio

Davidsson

et al. 2009

Public Health Nutr.

View full text Add to dashboard Cite

Objective: To investigate the association between Helicobacter pylori infection and anaemia. Design: Six cross-sectional studies. H. pylori infection was assessed by the [ 13 C]urea breath test using MS or IR analysis. Hb was measured for all countries. Ferritin and transferrin receptors were measured for Argentina, Bolivia, Mexico, and Venezuela. Setting: Health services in Argentina, Brazil and Mexico or public schools in Bolivia, Cuba and Venezuela. Subjects: In Argentina, 307 children aged 4-17 years referred to a gastroenterology unit; in Bolivia, 424 randomly selected schoolchildren aged 5-8 years; in Brazil, 1007 adults (157 men, 850 women) aged 18-45 years attending thirty-one primary healthcare units; in Cuba, 996 randomly selected schoolchildren aged 6-14 years; in Mexico, seventy-one pregnant women in their first trimester attending public health clinics; in Venezuela, 418 children aged 4-13 years attending public schools. Results: The lowest prevalence of H. pylori found was among children in Argentina (25?1 %) and the highest in Bolivia (74?0 %). In Bolivia, Cuba and Venezuela children showed similar prevalence of H. pylori infection as in Brazilian and Mexican adults (range 47?5 % to 81?8 %). Overall anaemia prevalence was 11?3 % in Argentina, 15?4 % in Bolivia, 20?6 % in Brazil, 10?5 % in Cuba and 8?9 % in Venezuela. Adjusted analyses allowing for confounding variables showed no association between H. pylori colonization and anaemia in any study. Hb, ferritin and transferrin receptor levels were also not associated with H. pylori infection in any country.

show abstract

Section: Discussionmentioning

confidence: 99%

Helicobacter pyloriis not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela

Santos

Boccio

Davidsson

et al. 2009

Public Health Nutr.

View full text Add to dashboard Cite

show abstract

“…on May 11, 2018. by guest www.bloodjournal.org From (n 5 15) coexistent autoimmune gastritis, 27 following H pylori eradication all previously refractory patients achieved normal Hb levels with follow-up periods ranging from 4 to 69 months (38 6 15 months, mean 6 1 SD). This was accompanied by a significant decrease in H pylori immunoglobulin G (IgG) antibodies and in serum gastrin levels.…”

Section: H Pylori Gastritismentioning

confidence: 99%

How I treat unexplained refractory iron deficiency anemia

Hershko

Camaschella

2014

Blood

Self Cite

138

140

View full text Add to dashboard Cite

Endoscopic gastrointestinal workup fails to establish the cause of iron deficiency anemia (IDA) in a substantial proportion of patients. In patients referred for hematologic evaluation with unexplained or refractory IDA, screening for celiac disease, autoimmune gastritis, Helicobacter pylori, and hereditary forms of IDA is recommended. About 4% to 6% of patients with obscure refractory IDA have celiac disease, and autoimmune gastritis is encountered in 20% to 27% of patients. Stratification by age cohorts in autoimmune gastritis implies a disease presenting as IDA many years before the establishment of clinical cobalamin deficiency. Over 50% of patients with unexplained refractory IDA have active H pylori infection and, after excluding all other causes of IDA, 64% to 75% of such patients are permanently cured by H pylori eradication. In young patients with a history suggestive of hereditary iron deficiency with serum ferritin higher than expected for IDA, mutations involving iron trafficking and regulation should be considered. Recognition of the respective roles of H pylori, autoimmune gastritis, celiac disease, and genetic defects in the pathogenesis of iron deficiency should have a strong impact on the current diagnostic workup and management of unexplained, or refractory, IDA.

show abstract

“…pylori infection is associated with iron deficiency, and this infection also impairs the response to iron therapy [49,50]. It seemed reasonable that by blocking iron absorption this common infestation might protect against iron overload.…”

Section: H Pylori Infectionmentioning

confidence: 99%

Iron storage disease: Facts, fiction and progress

Beutler

2007

Blood Cells, Molecules, and Diseases

View full text Add to dashboard Cite

There are many forms of iron storage disease, some hereditary and some acquired. The most common of the hereditary forms is HFE-associated hemochromatosis, and it is this disorder that is the main focus of this presentation. The body iron content is regulated by controlling absorption, and studies in the past decade have clarified, in part, how this regulation functions. A 25 amino acid peptide hepcidin is upregulated by iron and by inflammation, and it inhibits iron absorption and traps iron in macrophages by binding to and causing degradation of the iron transport protein ferroportin. Most forms of hemochromatosis results from dysregulation of hepcidin or defects of hepcidin or ferroportin themselves.Hereditary hemochromatosis was once considered to be very rare, but in the 1970s and 1980s, with the introduction of better diagnostic tests, it became to be considered the most common disease of Europeans. Controlled epidemiologic studies carried out in the last decade have shown, however, the disease itself actually is rare, and it is only the genotype and associated biochemical changes that are common. We do not understand why only a few homozygotes develop severe disease. It now seems unlikely that there are important modifying genes, and although alcohol is known to have some effect, excess drinking probably plays only a modest role in determining the hemochromatosis phenotype.Hereditary hemochromatosis is readily treated by phlebotomy. Secondary forms of the disease require chelation therapy, and the recent introduction of effective oral chelating agents is an important step forward in treating patients with disorders in which iron overload often proves to be fatal, such as thalassemia, myelodysplastic anemias, and dyserythropoietic anemias.While much has been learned about the regulation of iron homeostasis in the past decade, many mysteries remain and represent challenges that will keep us occupied for years to come.It is a great honor for me to present this lecture in memory of my good friend Bracha Ramot. It is because this lecture is in honor of Bracha that I do not feel the least bit uncomfortable speaking about iron storage diseases in a symposium entitled "Genomics and Molecular Biology of Hematopoietic Malignancies". I know that had it been possible to ask her whether this might be appropriate Bracha would have said: "Of course, Ernie. Talk about whatever you want to". That was her way. And, of course, Bracha was no stranger to iron metabolism. She was scientifically broad, a Renaissance hematologist. A MEDLINE search reveals 261 publications by Bracha and eight of those deal with iron --iron in thalassemia, iron in sideroblastic anemia, and iron in iron deficiency anemia.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable...

show abstract

A hematologist's view of unexplained iron deficiency anemia in males: Impact of Helicobacter pylori eradication

Cited by 45 publications

References 35 publications

Helicobacter pyloriis not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela

Helicobacter pyloriis not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela

How I treat unexplained refractory iron deficiency anemia

Iron storage disease: Facts, fiction and progress

Contact Info

Product

Resources

About