A helper NLR targets organellar membranes to trigger immunity
Tarhan Ibrahim,
Enoch Lok Him Yuen,
Hung-Yu Wang
et al.
Abstract:In plants, NLR (nucleotide-binding domain and leucine-rich repeat) proteins execute innate immunity through the formation of resistosomes that accumulate at the plasma membrane. However, the extent to which NLR resistosomes target other cellular membranes is unknown. Here, we show that the helper NLR NRG1 engages with multiple organellar membranes to trigger innate immunity. Compared to other helper NLRs, NRG1 and closely related RPW8-like NLRs (CCR-NLRs) possess extended N-termini with distinctive sequence si… Show more
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