A heavyweight knocked out

Green, Douglas R.

doi:10.1038/479048a

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Caspases: Focused Overview1

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2012

2015

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Cited by 4 publications

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“…Recently, genetic knockout of murine caspase-11 was shown to be protective against lipopolysaccharide exposure (Green 2011), which suggests a role in the innate immune response. In a separate study, caspase-11 knockout mice were protected from stroke (Kang and others 2000).…”

Section: Caspases: Focused Overviewmentioning

confidence: 99%

Caspase Inhibitors

Akpan

Troy

2012

Neuroscientist

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In ischemic stroke, apoptosis persists for days to weeks after the onset of an ischemic event. Cysteine-ASPartic proteASEs (caspases) are key mediators of apoptosis and neurodegeneration in stroke. The impact of caspase activity is not restricted to neuronal death, as caspases can exacerbate inflammation and alter glial function. Thus, caspases are logical therapeutic targets for this disease, but they have never been clinically evaluated due to a paucity of ideal drug candidates. Recent developments in caspase inhibition and drug delivery offer novel neuroprotective strategies for stroke, which are deliberated in this review.

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Section: Caspases: Focused Overviewmentioning

confidence: 99%