A healthy outcome of a pregnant woman with drug-resistant juvenile myoclonic epilepsy treated with brivaracetam

Brivaracetam and topiramate serum levels during pregnancy and delivery: a case report and a review of literature

“…Minor congenital malformations such as infantile hemangioma, congenital dermal melanocytosis and ankyloglossia were observed in two of three children (see Table 1 ). Navarro et al [ 14 ] reported the birth of a healthy child on BRV therapy during pregnancy in a patient with therapy-refractory juvenile myoclonic epilepsy. Landmark and colleagues [ 11 ] reported three healthy births during pregnancy with brivaracetam in two patients with epilepsy: Whereas one patient received BRV in monotherapy, the other also received perampanel and lacosamide as comedication.…”

“…of BRV in umbilical cord Conc. of BRV postpartum) Serum ratio (infant/mother) Newborn malformation Paolini et al [ 15 ] 3 P1*: 100 mg P2: 150 mg P3: 200 mg None None P3: LTG 450 mg – – – – – – – – – – – – Congenital dermal melanocytosis and ankyloglossia Infantile hemangioma on thumb and back None Landmark et al [ 11 ] 2 P 1: 150 mg P2: 200 mg P1: none P2: PER 8 mg, LCM 400 mg P1: 3,8 umol/l **(0.81 mg/l) P2: 6,6 umol/l **(1.40 mg/l) Twin 1: 4,1 umol/l **(0.87 mg/l) Twin 2: 4,2 umol/l **(0.89 mg/l) P2: 1, 2umol/l **(0.25 mg/l) P1: 4,4 umol/l **(0.93 mg/l) P2: 6,1 umol/l **(1.29 mg/l) 1.08 1.11 0.18 None None None Navarro [ 14 ] 1 200 mg none – – – – None *P1 = Patient 1, P2 = Patient 2, BRV = brivaracetam, ASM = antiseizure medication, LTG = lamotrigine, PER = perampanel, LCM = lacosamide **For better comparability of the data, the amount of substance was converted into weight units …”