A Hazard of Repeated Blood Transfusions

Hutcheson, James B.

doi:10.1001/jama.1952.72930200017011i

Cited by 7 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DISCUSSION: Though blood transfusions are acclaimed for their life enhancing properties, a darker side that is overlooked is their capacity to create serious complications. 7,8 The only blood transfusion borne infection identified in this study was hepatitis B infection: HBsAg positive children in age <1yr was 0%, 1-6 yrs. was 5.9%, 6-12yrs was12.5%.…”

Section: Resultsmentioning

confidence: 74%

To Determine the Incidence of Blood Transfusion Borne Infections in Children Receiving Recurrent Blood Transfusions

Shah¹,

Hatkar²,

Deosarkar³

et al. 2014

jemds

View full text Add to dashboard Cite

PARTICIPANTS: 50 children (<12yrs) requiring recurrent blood transfusions based on clinical and laboratory findings. METHODS: 50 children <12 year of age receiving recurrent blood transfusions were enrolled in the study i.e. those children who received more than two transfusions in the past were included. A detailed history was taken & physical examination was done. After consent, these patients were investigated for blood transfusion borne infections i.e. HIV, Hepatitis B & malaria. For Hepatitis B-HBsAg was done. For HIV-ELISA was done. For Malaria-Peripheral blood smear examinations for malarial parasites was done. Causes of anemia in these children requiring recurrent blood transfusions were also analyzed. RESULT: This prospective study conducted over a period of 3 months (April 2014 to June 2014) in the dept. of pediatrics, SBHGMC Dhule showed following results. Among the 459 patients admitted in ward during this period, 50 children were k/c/o anemia requiring recurrent blood transfusions (10.9%).The cause of anemia in these children were-Thalassemia major n=42 (84%)-Sickle cell anemia n=6 (12%)-Aplastic anemia n=2 (4%) Out of these children, 5 were HBsAg positive (10%).None of these children was positive for HIV/malaria. Among HBsAg positive children 3 children (60%) had received hepatitis B vaccine in the past. None of the parents of HBsAg positive children were HBsAg positive. CONCLUSION: The commonest cause of recurrent blood transfusion in the study was Thalassemia major. The incidence of blood transfusion borne infection in these children is 10%. All being hepatitis B. Among HBsAg positive children, 60% of the children had received hepatitis B vaccine in the past. This concludes a) 0ne should be stricter in selecting a donor for blood transfusion. b) Need for new screening method to detect these infections in donated blood. c) Need for booster dose of hepatitis B vaccine in children requiring recurrent blood transfusions.

show abstract

Section: Resultsmentioning

confidence: 74%