2023
DOI: 10.1002/alz.13050
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A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease

Abstract: BackgroundHaptoglobin (HP) is an antioxidant of apolipoprotein E (APOE), and previous reports have shown HP binds with APOE and amyloid beta (Aβ) to aid its clearance. A common structural variant of the HP gene distinguishes it into two alleles: HP1 and HP2.MethodsHP genotypes were imputed in 29 cohorts from the Alzheimer's Disease Genetics Consortium (N = 20,512). Associations between the HP polymorphism and Alzheimer's disease (AD) risk and age of onset through APOE interactions were investigated using regre… Show more

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Cited by 1 publication
(2 citation statements)
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“…Plasma HP, which is primarily produced by hepatocytes in the liver, is a particularly important hemoglobin-binding protein that removes hemoglobin from the circulation ( 45 ). Various additional functions of HP have been discovered, including serving as an acute phase 2-acid response glycoprotein, an antioxidant of apolipoprotein E (APOE), an anti-inflammatory protein, and an Aβ clearance facilitator ( 46 , 47 ). In the current study, HP was significantly upregulated in the epilepsy group compared to that in the healthy control group.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Plasma HP, which is primarily produced by hepatocytes in the liver, is a particularly important hemoglobin-binding protein that removes hemoglobin from the circulation ( 45 ). Various additional functions of HP have been discovered, including serving as an acute phase 2-acid response glycoprotein, an antioxidant of apolipoprotein E (APOE), an anti-inflammatory protein, and an Aβ clearance facilitator ( 46 , 47 ). In the current study, HP was significantly upregulated in the epilepsy group compared to that in the healthy control group.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, a significant positive correlation between the serum HP level and the severity of cognitive impairment was observed in patients with AD ( 47 , 50 ). This association is believed to occur through the modification of the effects of APOE, another genetic factor implicated in AD progression ( 46 ). Although research on the relationship among HP, epilepsy, and Aβ is currently limited, the present findings suggest possible links among these factors.…”
Section: Discussionmentioning
confidence: 99%