A Handheld Microwave Thermoacoustic Imaging System With an Impedance Matching Microwave-Sono Probe for Breast Tumor Screening

Wu, Linghua; Cheng, Zhongwen; Ma, Yan; Li, Yujing; Ren, Mingyang; Xing, Da; Qin, Huan

doi:10.1109/tmi.2021.3131423

Cited by 20 publications

(16 citation statements)

References 56 publications

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“…A newly reported focused microwave mechanism may be used to reduce the demanded microwave power to get a desired SNR for a deeply embedded hemorrhage spot [70], [71]. The proposed method also holds the potential to be realized by a handheld system that is more suitable for clinical usage [72].…”

Section: Discussionmentioning

confidence: 99%

Deep-Learning-Enabled Microwave-Induced Thermoacoustic Tomography Based on ResAttU-Net for Transcranial Brain Hemorrhage Detection

Jin

et al. 2023

IEEE Trans. Biomed. Eng.

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Hemorrhagic stroke is a leading threat to human's health. The fast-developing microwave-induced thermoacoustic tomography (MITAT) technique holds potential to do brain imaging. However, transcranial brain imaging based on MITAT is still challenging due to the involved huge heterogeneity in speed of sound and acoustic attenuation of human skull. This work aims to address the adverse effect of the acoustic heterogeneity using a deep-learning-based MITAT (DL-MITAT) approach for transcranial brain hemorrhage detection. Methods: We establish a new network structure, a residual attention U-Net (ResAttU-Net), for the proposed DL-MITAT technique, which exhibits improved performance as compared to some traditionally used networks. We use simulation method to build training sets and take images obtained by traditional imaging algorithms as the input of the network. Results: We present ex-vivo transcranial brain hemorrhage detection as a proof-of-concept validation. By using an 8.1-mm thick bovine skull and porcine brain tissues to perform ex-vivo experiments, we demonstrate that the trained ResAttU-Net is capable of efficiently eliminating image artifacts and accurately restoring the hemorrhage spot. It is proved that the DL-MITAT method can reliably suppress false positive rate and detect a hemorrhage spot as small as 3 mm. We also study effects of several factors of the DL-MITAT technique to further reveal its robustness and limitations. Conclusion: The proposed ResAttU-Net-based DL-MITAT method is promising for mitigating the acoustic inhomogeneity issue and performing transcranial brain hemorrhage detection. Significance: This work provides a novel ResAttU-Net-based DL-MITAT paradigm and paves a compelling route for transcranial brain hemorrhage detection as well as other transcranial brain imaging applications.

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Section: Discussionmentioning

confidence: 99%

Deep-Learning-Enabled Microwave-Induced Thermoacoustic Tomography Based on ResAttU-Net for Transcranial Brain Hemorrhage Detection

Jin

et al. 2023

IEEE Trans. Biomed. Eng.

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“…Although US imaging is easy to operate and provides real-time images, the low spatial resolution and the existence of speckle artifacts restrict the accuracy of ablation. 5 On the other hand, the gradient distribution of temperature during microwave ablation tends to result in insufficient thermal delivery in the "transitional zone" far away from the microwave antenna, which is easy to cause tumor residue and recurrence of more aggressive phenotypes for the HCC with large volume, less regular shape and strong infiltration. 6 Thus, providing a high-resolution, real-time, and noninvasive imaging technique for intraoperative guidance and controlling postoperative residual tumor recurrence are urgent clinical requirements.…”

Section: ■ Introductionmentioning

confidence: 99%

“…For example, MRI and conventional CT are inaccessible to guide surgical operation in real time, limited by the imaging time and scanning mechanism. Although US imaging is easy to operate and provides real-time images, the low spatial resolution and the existence of speckle artifacts restrict the accuracy of ablation . On the other hand, the gradient distribution of temperature during microwave ablation tends to result in insufficient thermal delivery in the “transitional zone” far away from the microwave antenna, which is easy to cause tumor residue and recurrence of more aggressive phenotypes for the HCC with large volume, less regular shape and strong infiltration .…”

Section: Introductionmentioning

confidence: 99%

Thermoacoustic Imaging-Guided Thermo-Chemotherapy for Hepatocellular Carcinoma Sensitized by a Microwave-Responsive Nitric Oxide Nanogenerator

Wen

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Imaging-guided percutaneous microwave thermotherapy has been regarded as an important alternative nonsurgical therapeutic strategy for hepatocellular carcinoma (HCC) that provides excellent local tumor control and favorable survival benefit. However, providing a high-resolution, real-time, and noninvasive imaging technique for intraoperative guidance and controlling postoperative residual tumor recurrence are urgent needs for the clinical setting. In this study, a cisplatin (CDDP)-loaded nanocapsule (NPs@CDDP) with microwave responsive property was prepared to simultaneously serve as a contrast agent of emerging thermoacoustic imaging and a sensitizing agent of microwave thermo-chemotherapy. Accompanying the enzymolysis in the tumor microenvironment, the NPs@CDDP responsively release l-arginine (l-Arg) and CDDP. l-Arg with excellent microwave-absorbing property allowed it to serve as a thermoacoustic imaging contrast agent for accurately delineating the tumor and remarkably increasing tumor temperature under ultralow power microwave irradiation. Apart from the chemotherapeutic effect, CDDP elevated the intracellular H2O2 level through cascade reactions and further accelerated the continuous transformation of l-Arg to nitric oxide (NO), which endowed the NPs@CDDP with NO-generation capability. Notably, the high concentration of intracellular NO was proved to aggravate lipid peroxidation and greatly improved the efficacy of microwave thermo-chemotherapy. Thereby, NPs@CDDP was expected to serve as a theranostic agent integrating the functions of tumor microenvironment-responsive drug delivery system, contrast agent of thermoacoustic imaging, thermal sensitizing agent, and NO nanogenerator, which was promising to provide a potential imaging-guided therapeutic strategy for HCC.

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“…The antennae utilized in this type of biomedical imaging system should cover as much of the microwave medical imaging systems’ frequency band as possible while still being compact to fit in reasonably sized imaging systems. Ultra-wideband (UWB) antennae satisfy this requirement since they are compact and cover a considerable portion of the frequency range required in microwave medical imaging systems [ 10 ]. They should operate between 3.1 GHz and 10.6 GHz according to the specifications in [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Microwave Imaging Approach for Breast Cancer Detection Using a Tapered Slot Antenna Loaded with Parasitic Components

et al. 2023

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In this paper, a wideband antenna is proposed for ultra-wideband microwave imaging applications. The antenna is comprised of a tapered slot ground, a rectangular slotted patch and four star-shaped parasitic components. The added slotted patch is shown to be effective in improving the bandwidth and gain. The proposed antenna system provides a realized gain of 6 dBi, an efficiency of around 80% on the radiation bandwidth, and a wide impedance bandwidth (S11 < −10 dB) of 6.3 GHz (from 3.8 to 10.1 GHz). This supports a true wideband operation. Furthermore, the fidelity factor for face-to-face (FtF) direction is 91.6%, and for side by side (SbS) is 91.2%. This proves the excellent directionality and less signal distortion of the designed antenna. These high figures establish the potential use of the proposed antenna for imaging. A heterogeneous breast phantom with dielectric characteristics identical to actual breast tissue with the presence of tumors was constructed for experimental validation. An antenna array of the proposed antenna element was situated over an artificial breast to collect reflected and transmitted waves for tumor characterization. Finally, an imaging algorithm was used to process the retrieved data to recreate the image in order to detect the undesirable tumor object inside the breast phantom.

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A Handheld Microwave Thermoacoustic Imaging System With an Impedance Matching Microwave-Sono Probe for Breast Tumor Screening

Cited by 20 publications

References 56 publications

Deep-Learning-Enabled Microwave-Induced Thermoacoustic Tomography Based on ResAttU-Net for Transcranial Brain Hemorrhage Detection

Deep-Learning-Enabled Microwave-Induced Thermoacoustic Tomography Based on ResAttU-Net for Transcranial Brain Hemorrhage Detection

Thermoacoustic Imaging-Guided Thermo-Chemotherapy for Hepatocellular Carcinoma Sensitized by a Microwave-Responsive Nitric Oxide Nanogenerator

Microwave Imaging Approach for Breast Cancer Detection Using a Tapered Slot Antenna Loaded with Parasitic Components

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