A handheld device for creating cartilage blunt impact injuries in survival animal models

Pedersen, Douglas R.; Rudert, Maximilian; Heckelsmiller, D.J.; Baer, Thomas; Fredericks, Douglas C.; Goetz, Jessica E.

doi:10.1016/j.joca.2016.01.729

Cited by 1 publication

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“… 14 We developed and calibrated an easy-to-use handheld pneumatic impactor to create reproducible cartilage damage. 13 …”

Section: Methodsmentioning

confidence: 99%

“… 8 – 10 These preclinical models permit isolation of traumatic injury features but must include means of creating realistic joint injury simulating in vivo clinical joint trauma. 11 , 12 We have created reproducible cartilage impact damage with a handheld pneumatic impactor 13 through an anterior partial meniscectomy (APM) 14 in a survival goat model of PTOA. Longitudinal clinical MRI sequences revealed bone contusion progression from preinjury normal through 6 months after traumatic injury in the goat stifle model.…”

Section: Introductionmentioning

confidence: 99%

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Bone contusion progression from traumatic knee injury: association of rate of contusion resolution with injury severity

Pedersen¹,

El‐Khoury²,

Thedens³

et al. 2017

OAJSM

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BackgroundBone contusions are frequently encountered in magnetic resonance imaging (MRI) evaluation of knee anterior cruciate ligament (ACL) injuries. Their role as indicators of injury severity remains unclear, primarily due to indeterminate levels of joint injury forces and to a lack of preinjury imaging.PurposeThe purpose of this study was to 1) quantify bone contusion pathogenesis following traumatic joint injuries using fixed imaging follow-ups, and 2) assess the feasibility of using longitudinal bone contusion volumes as an indicator of knee injury severity.Study designProspective sequential MRI follow-ups of a goat cohort exposed to controlled stifle trauma in vivo were compared to parallel clinical MRI follow-ups of a human ACL tear patient series.MethodsReproducible cartilage impact damage of various energy magnitudes was applied in a survival goat model, coupled with partial resection of anterior portions of medial menisci. Both emulate injury patterns to the knee osteochondral structures commonly encountered in human ACL injury imaging as well as instability from resultant ligament laxity. Longitudinal clinical MRI sequences portrayed stifle bone contusion evolution through 6 months after the inciting event.ResultsIn the first 2 weeks, biological response variability dominated the whole-joint response with no apparent correlation to trauma severity. Control goats subjected to partial meniscectomy alone exhibited minimal bone response. Thereafter, 0.6 J impact bone contusions portrayed a faster rate of resolution than those induced by 1.2 J cartilage impacts.ConclusionBone contusion sizes combined with time of persistence are likely better measures of joint injury severity than isolated bone contusion volume.

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“… 14 We developed and calibrated an easy-to-use handheld pneumatic impactor to create reproducible cartilage damage. 13 …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bone contusion progression from traumatic knee injury: association of rate of contusion resolution with injury severity

Pedersen¹,

El‐Khoury²,

Thedens³

et al. 2017

OAJSM

View full text Add to dashboard Cite

show abstract

A handheld device for creating cartilage blunt impact injuries in survival animal models

Cited by 1 publication

References 0 publications

Bone contusion progression from traumatic knee injury: association of rate of contusion resolution with injury severity

Bone contusion progression from traumatic knee injury: association of rate of contusion resolution with injury severity

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