A Hand-Held, Intra-Operative Positron Imaging Probe for Surgical Applications

Sabet, Hamid; Stack, Brendan C.; Nagarkar, Vivek V.

doi:10.1109/tns.2015.2446434

Cited by 25 publications

(21 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(c-e) Augmented reality overlay of gamma camera findings within the anatomical context of the patient during head and neck cancer SN procedure (from [255]). (f) Setup of a portable beta+ camera for radioguided surgery, with evaluation in a tongue tumor rabbit model showing uptake in primary tumor (g) and lymph nodes (h) using 18 F-FDG (from [162]).…”

Section: Portable Gamma (γ) Camerasmentioning

confidence: 99%

“…Although intraoperative imaging of PET radiopharmaceuticals with a portable γ camera has not been shown yet, some research groups are pioneering this use with handheld β + cameras (see Figure 2(e-g)) [124,[160][161][162][163][164]].…”

Section: Beta (β) Camerasmentioning

confidence: 99%

“…This scintillation stack is generally coupled to either a position-sensitive PMT, silicon photomultiplier (SiPM) detector arrays or an EMCCD. Current prototype systems hardly use any collimation, though it is suggested that shielding on the sides and back would be a requirement in vivo, preventing detector noise from lesion surrounding anatomies [160,162].…”

Section: Background and Recent Advances Similar As Whatmentioning

confidence: 99%

See 2 more Smart Citations

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

View full text Add to dashboard Cite

Introduction: Radioguided surgery is an ever-evolving part of nuclear medicine. In fact, this nuclear medicine sub-discipline actively bridges non-invasive molecular imaging with surgical care. Next to relying on the availability of radio-and bimodal-tracers, the success of radioguided surgery is for a large part dependent on the imaging modalities and imaging concepts available for the surgical setting. With this review, we have aimed to provide a comprehensive update of the most recent advances in the field. Areas covered: We have made an attempt to cover all aspects of radioguided surgery: 1) the use of radioisotopes that emit γ, β + , and/or β − radiation, 2) hardware developments ranging from probes to 2D cameras and even the use of advanced 3D interventional imaging solutions, and 3) multiplexing solutions such as dual-isotope detection or combined radionuclear and optical detection. Expert opinion: Technical refinements in the field of radioguided surgery should continue to focus on supporting its implementation in the increasingly complex minimally invasive surgical setting, e.g. by accommodating robot-assisted laparoscopic surgery. In addition, hybrid concepts that integrate the use of radioisotopes with other image-guided surgery modalities such as fluorescence or ultrasound are likely to expand in the future.

show abstract

Section: Portable Gamma (γ) Camerasmentioning

confidence: 99%

Section: Beta (β) Camerasmentioning

confidence: 99%

Section: Background and Recent Advances Similar As Whatmentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

View full text Add to dashboard Cite

show abstract

“…Detection of bone tumors and parathyroid adenoma, radioimmunoguided surgery for colon cancer, sentinel-node mapping for breast tumor or melanoma tumor therapy, are typical applications of RGS [3]. In RGS, though gamma-ray radiotracers are typically adopted [4][5][6][7], also βradioisotopes can be used [8][9][10] as well as β + sources [11][12][13][14]. The success of RGS depends on the progress of the research on radiopharmaceuticals and intraoperative probes.…”

Section: Introductionmentioning

confidence: 99%

“…CA masks can increase the geometric efficiency by increasing the number of apertures while keeping https://doi.org/10.1016/j.ejmp.2019. 12 the resolution of a single aperture. They are fabricated on an absorbing substrate by arranging many identical holes in a specific 2D pattern.…”

Section: Introductionmentioning

confidence: 99%

CdTe compact gamma camera for coded aperture imaging in radioguided surgery

et al. 2020

View full text Add to dashboard Cite

Improvement of phoswich detector‐based β+/γ‐ray discrimination algorithm with deep learning

Kim

Lee

et al. 2023

Medical Physics

View full text Add to dashboard Cite

BackgroundPositron probes can accurately localize malignant tumors by directly detecting positrons emitted from positron‐emitting radiopharmaceuticals that accumulate in malignant tumors. In the conventional method for direct positron detection, multilayer scintillator detection and pulse shape discrimination techniques are used. However, some γ‐rays cannot be distinguished by conventional methods. Accordingly, these γ‐rays are misidentified as positrons, which may increase the error rate of positron detection.PurposeTo analyze the energy distribution in each scintillator of the multilayer scintillator detector to distinguish true positrons and γ‐rays and to improve the positron detection algorithm by discriminating true and false positrons.MethodsWe used Autoencoder, an unsupervised deep learning architecture, to obtain the energy distribution data in each scintillator of the multilayer scintillator detector. The Autoencoder was trained to separate the combined signals generated from the multilayer scintillator detector into two signals of each scintillator. An energy window was then applied to the energy distribution obtained using the trained Autoencoder to distinguish true positrons from false positrons. Finally, the performance of the proposed method and conventional positron detection algorithm was evaluated in terms of the sensitivity and error rate for positron detection.ResultsThe energy distribution map obtained using the trained Autoencoder was proven to be similar to that of the simulated results. Furthermore, the proposed method demonstrated a 29.79% (+0.42%p) increase in positron detection sensitivity compared to the conventional method, both having an equal error rate of 0.48%. However, when both methods were set to have the same sensitivity of 1.83%, the proposed method had an error rate that was 25.0% (−0.16%p) lower than that of the conventional method.ConclusionsWe proposed and developed an Autoencoder‐based positron detection algorithm that can discriminate between true and false positrons with a smaller error rate than conventional methods. We verified that the proposed method could increase the positron detection sensitivity while maintaining a low error rate compared to the conventional method. If the proposed algorithm is implemented in handheld positron detection probes or cameras, diseases such as cancers can be more accurately localized in a shorter time compared with using traditional methods.

show abstract

A Hand-Held, Intra-Operative Positron Imaging Probe for Surgical Applications

Cited by 25 publications

References 27 publications

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

CdTe compact gamma camera for coded aperture imaging in radioguided surgery

Improvement of phoswich detector‐based β+/γ‐ray discrimination algorithm with deep learning

Contact Info

Product

Resources

About