A halide perovskite/lead sulfide heterostructure with enhanced photoelectrochemical performance for the sensing of alkaline phosphatase (ALP)

Deng, Lei; Ma, Fanghui; Yang, Minghui; Li, Xiaoqing; Chen, Xiang

doi:10.1039/d2cc06142b

Cited by 13 publications

(3 citation statements)

References 27 publications

(31 reference statements)

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“…The potential of the PEC sensing platform for practical application was investigated by detecting different activities of ALP in human serum samples by the standard addition method . The samples were pretreated according to the previously reported method . The recoveries are in the range of 98.1–106.2%, and the relative standard deviations (RSD) range between 1.7 and 6.3% (Table S3).…”

Section: Resultsmentioning

confidence: 99%

“…57 The samples were pretreated according to the previously reported method. 58 The recoveries are in the range of 98.1−106.2%, and the relative standard deviations (RSD) range between 1.7 and 6.3% (Table S3). Accordingly, the results indicate that the prepared PEC sensing platform has the potential to analyze the ALP content of real samples.…”

Section: Synthesis Of Biobr and Biobr/cumof Composites With Ovs (Vo-b...mentioning

confidence: 99%

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Target-Induced Photocurrent-Polarity-Switching PEC Sensing Platform Based on In Situ Generation of Oxygen Vacancy-Modulated Energy Band Structures

Fan,

Lai,

Shao

et al. 2023

Anal. Chem.

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The polarity of the photocurrent can be modulated by tunable bipolar photoelectrochemical (PEC) behavior, which is anticipated to address the issues of high background signal caused by traditional unidirectional increasing/decreasing response and false-positive/false-negative problems. Here, a new approach is suggested for the first time, which employs a target-induced enzyme-catalyzed reaction and in situ oxygen vacancy (OV) generation to achieve heterojunction photocurrent switching for highly sensitive detection of alkaline phosphatase (ALP). Among them, the ALP can catalyze the decomposition of ascorbic acid phosphate to produce ascorbic acid, which not only acts as an electron donor to change the redox environment but also acts as a reducing agent to introduce OVs into BiOBr semiconductors in cooperation with illumination. The introduction of vacancies can effectively modulate the energy band structure of BiOBr, while with the change of redox conditions, the transfer path of photogenerated carriers is changed, thus realizing the switching of photocurrents, which leads to its use in the construction of a negative-background anti-interference PEC sensing platform, achieving a wide linear range from 0.005 to 500 U•L −1 with a low detection limit of 0.0017 U•L −1 . In conclusion, the photocurrent switching operation of this system is jointly regulated by chemistry, optics, and carrier motion, which provides a new idea for the construction of a PEC sensing platform based on photocurrent polarity switching.

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Section: Resultsmentioning

confidence: 99%

Section: Synthesis Of Biobr and Biobr/cumof Composites With Ovs (Vo-b...mentioning

confidence: 99%

Target-Induced Photocurrent-Polarity-Switching PEC Sensing Platform Based on In Situ Generation of Oxygen Vacancy-Modulated Energy Band Structures

Fan,

Lai,

Shao

et al. 2023

Anal. Chem.

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“…Recently, ligands or small molecules containing sulfur elements have been reported to stabilize perovskite [ 15 , 16 ]. For instance, a sensitive biosensor for the detection of H 2 S was achieved by creating a strong Pb–S bond with perovskite [ 17 , 18 ]. The ligands with sulfur, such as 1-dodecanethiol (DSH) [ 19 ], 4-aminobenzene sulfonic acid (SA) [ 20 ] and dodecylbenzene sulfonic (DBSA) [ 21 ], were found to improve the fluorescence of perovskite in water, indicating that it is of great potential to modify perovskite using ligands containing sulfur.…”

Section: Introductionmentioning

confidence: 99%

One-Step Ultrasonic Preparation of Stable Bovine Serum Albumin-Perovskite for Fluorescence Analysis of L-Ascorbic Acid and Alkaline Phosphatase

Deng,

Huang,

Zhang

et al. 2023

Biosensors

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Halide lead perovskite has attracted increased attention due to its excellent optical properties. However, the poor stability of the halide lead perovskite nanocrystals has been a major obstacle to their application in biosensing. Here, we proposed a method to synthesize CsPbBr3/BSA NCs perovskite using bovine serum albumin (BSA) as a zwitterion ligand. Then, a fluorescent sensor for alkaline phosphatase determination based on CsPbBr3/BSA NCs was successfully built via the interaction of L-ascorbic acid (AA) with BSA on the perovskite surface. Under optimal conditions, the sensor showed a linear concentration range from 50 to 500 μM with a detection limit of 28 μM (signal-to-noise ratio of 3) for AA, and demonstrated a linear concentration range from 40 to 500 U/L with a detection limit of 15.5 U/L (signal-to-noise ratio of 3) for alkaline phosphatase (ALP). In addition, the proposed fluorescent biosensor exhibited good selectivity and recovery in the determination of ALP in human serum. This strategy offers an innovative way for enhancing the water stability of lead halide perovskite and promoting their application in biosensing areas.

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Detection of alkaline phosphatase activity with a CsPbBr3/Y6 heterojunction-based photoelectrochemical sensor

Shao,

Deng,

et al. 2024

Microchim Acta

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A halide perovskite/lead sulfide heterostructure with enhanced photoelectrochemical performance for the sensing of alkaline phosphatase (ALP)

Abstract: For the construction of halide perovskite based photoelectrochemical (PEC) biosensors in aqueous solution, the balance between retaining the excellent photoelectric performances of halide perovskite and the protective modification of halide...

Cited by 13 publications

References 27 publications

Target-Induced Photocurrent-Polarity-Switching PEC Sensing Platform Based on In Situ Generation of Oxygen Vacancy-Modulated Energy Band Structures

Target-Induced Photocurrent-Polarity-Switching PEC Sensing Platform Based on In Situ Generation of Oxygen Vacancy-Modulated Energy Band Structures

One-Step Ultrasonic Preparation of Stable Bovine Serum Albumin-Perovskite for Fluorescence Analysis of L-Ascorbic Acid and Alkaline Phosphatase

Detection of alkaline phosphatase activity with a CsPbBr3/Y6 heterojunction-based photoelectrochemical sensor

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