Abstract:The classic Ugi reaction is a four‐component coupling process that involves a carboxylic acid, a carbonyl compound, an amine, and an isocyanide. All reaction components are in a dynamic equilibrium with several intermediates, until an irreversible intramolecular 1,4‐
O
→
N
acyl transfer leads to the formation of an
N
‐acylamino acid amide. If chiral components are used in this reaction, a mixture of diastereomers is generally formed with m… Show more
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