A haemagglutination inhibition test kit for routine analysis of erythropoietin

Omran, Narges; Neumann, E

doi:10.1007/bf01008452

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…However, it has to be considered that the hemagglutination-inhibition test for idEP determinations might suffer from a lack of sensitivity and/or specificity under certain experimental conditions [23].…”

Section: Discussionmentioning

confidence: 99%

Is the Erythropoietin-Hematocrit Feedback Control Operative in Chronic Renal Failure?

Walle¹,

Weiland²,

Proppe³

et al. 1982

Nephron

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Transfusion studies in 23 chronic uremic patients with low hematocrit (HCT) values showed that (1) the pretransfusional immunodetectable (id) serum erythropoietin (EP) levels were within the normal range for healthy people; (2) the posttransfusional idEP levels remained unchanged; (3) 3 patients with analgesic nephropathy and high pretransfusional bioassayed (bio) EP levels had markedly suppressed posttransfusional bioEP, 6 patients with other kidney diseases had undetectable bioEP levels; (4) the raised pretransfusional reticulocyte (RETI) counts were markedly reduced by transfusions in all patients. We conclude that, in chronic uremic patients with elevated pretransfusional levels of bioEP, the bioEP is positively correlated with the kinetics of RETI and negatively correlated with the HCT. This correlation was not found for idEP.

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Section: Discussionmentioning

confidence: 99%

Is the Erythropoietin-Hematocrit Feedback Control Operative in Chronic Renal Failure?

Walle¹,

Weiland²,

Proppe³

et al. 1982

Nephron

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Nachweis von Erythropoietin Vergleich eines biologischen Verfahrens mit einem Haemagglutinations-Hemmtest

Essers

Heilmann

1981

Klin Wochenschr

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The results from a biological test for erythropoietin (using the rate of iron absorption in polycythemic mice) and a commercially-available immunological test (haemagglutination-inhibition test) were compared. Of 19 batches of the immunological test which were investigated, 7 batches were completely inactive and a further 3 batches reacted only with the test serum supplied with the test. There was a poor correlation between the results from the biological and the immunological measurements, both on patients with high and those with low serum erythropoietin levels. The difficulty of the immunological erythropoietin test is that pure erythropoietin is not sufficiently available. The immunological test investigated here does not use pure erythropoietin. Aside from this, pathophysiological considerations would lead one to expect basic differences between the results from immunological and biological tests.

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Renal erythropoietin: Properties and production

Jelkmann

Reviews of Physiology, Biochemistry and Pharmacology

104

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A haemagglutination inhibition test kit for routine analysis of erythropoietin

Abstract: A commercially available haemagglutination inhibition test kit for routine analysis of erythropoietin was shown to be unable to detect elevated levels of serum Epo.

Cited by 3 publications

References 7 publications

Is the Erythropoietin-Hematocrit Feedback Control Operative in Chronic Renal Failure?

Is the Erythropoietin-Hematocrit Feedback Control Operative in Chronic Renal Failure?

Nachweis von Erythropoietin Vergleich eines biologischen Verfahrens mit einem Haemagglutinations-Hemmtest

Renal erythropoietin: Properties and production

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