A. H. Fox Strangways

Howes, Frank

doi:10.1093/ml/l.1.8

Cited by 3 publications

(3 citation statements)

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“…Actually, Howes et al [1969] ob served that after 3 h of treatment of Tricho monas foetus cultures with 20 //g/ml, there was an appreciable reduction in the number of individuals, effect much more pro nounced after 12 h. Likewise, they obtained similar results with Trichomonas vaginalis. These authors also reported that for the tro phozoites of Entamoeba histolytica the min imal inhibitory concentration was 40 /<g/ml and the minimal lethal concentration was 80 /¿g/ml.…”

Section: Discussionmentioning

confidence: 76%

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The Effect of Tinidazole on Several Ciliates

Alonso¹

1979

Chemotherapy

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The effect of tinidazole on several ciliates (Stylonychia muscorum, Stylonychia mytilus, Tetrahymena pyriformis, Vorticella campanula) has been studied. There is a very pronounced difference in sensitivity against this drug between the free-living ciliates here investigated and certain parasitic protozoa. A high resistance of the free-living ciliates against tinidazole, probably due to their aerobic condition, has been found. Nonetheless, tinidazole at high doses (1–3 mg/ml) caused severe alterations in 3 of the 4 aerobic ciliate species here studied.

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Section: Discussionmentioning

confidence: 76%

“…Therefore, it is very likely that the cytotoxic effect of tinidazole be also much more effective in anaerobic condi tions. In that way, it could be explained the fact that the nitroimidazoles are inactive against different species of Trypanosoma [Howes et al, 1969;Prince et al, 1969].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Tinidazole on Several Ciliates

Alonso¹

1979

Chemotherapy

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“…It is in clinical trials for use in combination therapies for several different types of carcinomas [37,56,57]. Phenoxodiol is in phase II clinical trial for the treatment of ovarian cancer [37,58,59]. Vadimezan (DMXAA) is a flavone acetic acid derivative with vascular-disrupting activity, which has been evaluated for non-small-cell lung cancer and showed encouraging results in phase II clinical trials, although the results of phase III were not promising [60].…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Silico Studies to Explore Structural Features of Flavonoids for Aldehyde Oxidase Inhibition

Hamzeh‐Mivehroud

Rahmani

Feizi

et al. 2014

Archiv der Pharmazie

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Aldehyde oxidase (AO), an important enzyme in the biotransformation of drugs and xenobiotics, is inhibited by flavonoids. This enzyme can metabolize both aldehydes and N-heterocycles. In this work, a set of 15 flavonoids was assessed for inhibitory activity on the AO oxidation of vanillin as an aldehyde substrate. Spectrophotometrically determined IC50 values showed that myricetin, quercetin, and epicatechin were the most potent inhibitors. The results also revealed that the inhibition of vanillin oxidation by flavonoids was stronger than that of phenanthridine oxidation (an N-heterocyclic substrate) as reported previously. In order to investigate the important structural features responsible for the inhibitory effects of the studied flavonoids, a quantitative structure-activity relationship (QSAR) analysis was performed. This study showed that the size of the flavonoids was the most important factor inversely affecting their potencies. The QSAR model can be used more broadly to predict the AO inhibitory activity of flavonoid-like structures for application in food-drug and drug-drug interaction studies.

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The Foundation of Music & Letters

Collins¹

2019

Music and Letters

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A. H. Fox Strangways

Cited by 3 publications

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The Effect of Tinidazole on Several Ciliates

The Effect of Tinidazole on Several Ciliates

In Vitro and In Silico Studies to Explore Structural Features of Flavonoids for Aldehyde Oxidase Inhibition

The Foundation of Music & Letters

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