A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection

Jacobson, Amanda; Lam, Lilian H.; Rajendram, Manohary; Tamburini, Fiona B.; Honeycutt, Jared; Pham, Trung H.M.; Treuren, Will Van; Pruss, Kali M.; Stabler, Stephen Russell; Lugo, Kyler A.; Bouley, Donna M.; Vilches-Moure, José G.; Smith, Mark; Sonnenburg, Justin L.; Bhatt, Ami S.; Huang, Kerwyn Casey; Monack, Denise M.

doi:10.1016/j.chom.2018.07.002

Cited by 350 publications

(283 citation statements)

References 62 publications

Supporting

Mentioning

269

Contrasting

Unclassified

Order By: Relevance

“…8 In animals, SCFA producers confer colonization resistance against common enteric pathogens, including VRE. [40][41][42][43][44] This study also observed an inverse relationship between SCFA producers and Enterococcus. In addition to higher SCFA producers, dietary fiber intake was associated with improved fecal microbial diversity.…”

Section: Discussionsupporting

confidence: 71%

“…Animal studies and data from ambulatory patients suggest that increased SCFA levels may have clinical benefits that are relevant for ICU patients . In animals, SCFA producers confer colonization resistance against common enteric pathogens, including VRE . This study also observed an inverse relationship between SCFA producers and Enterococcus .…”

Section: Discussionsupporting

confidence: 58%

See 1 more Smart Citation

Relationship Between Dietary Fiber Intake and Short‐Chain Fatty Acid–Producing Bacteria During Critical Illness: A Prospective Cohort Study

Moscoso

Porter

et al. 2019

J Parenter Enteral Nutr

View full text Add to dashboard Cite

Background Dietary fiber increases short‐chain fatty acid (SCFA)‐producing bacteria yet is often withheld in the intensive care unit (ICU). This study evaluated the safety and effect of fiber in ICU patients with gut microbiome sampling. Methods This was a retrospective study nested within a prospective cohort. Adults were included if newly admitted to the ICU and could receive oral nutrition, enteral feedings, or no nutrition. Rectal swabs were performed at admission and 72 hours later. The primary exposure was fiber intake over 72 hours, classified in tertiles and adjusted for energy intake. The primary outcome was the relative abundance (RA) of SCFA producers via 16S RNA sequencing and the tolerability of fiber. Results In 129 patients, median fiber intake was 13.4 g (interquartile range 0–35.4 g) over 72 hours. The high‐fiber group had less abdominal distension (11% high fiber vs 28% no fiber, P < .01) and no increase in diarrhea (15% high fiber vs 13% no fiber, P = .94) or other adverse events. The median RA of SCFA producers after 72 hours was 0.40%, 0.50%, and 1.8% for the no‐, low‐, and high‐fiber groups (P = .05 for trend). After correcting for energy intake, the median RA of SCFA producers was 0.41%, 0.32%, and 2.35% in the no‐, low‐, and high‐corrected‐fiber categories (P < .01). These associations remained significant after adjusting for clinical factors including antibiotics. Conclusions During the 72 hours after ICU admission, fiber was well tolerated, and higher fiber intake was associated with more SCFA‐producers.

show abstract

Section: Discussionsupporting

confidence: 71%

Section: Discussionsupporting

confidence: 58%

Relationship Between Dietary Fiber Intake and Short‐Chain Fatty Acid–Producing Bacteria During Critical Illness: A Prospective Cohort Study

Moscoso

Porter

et al. 2019

J Parenter Enteral Nutr

View full text Add to dashboard Cite

show abstract

“…This includes colonization resistance, where commensals occupy distinct biological niches and thereby prevent pathogens from establishing themselves in the microbial ecosystem (Fig ). In addition, in some instances members of microbiota, e.g., of the Bacteroides family, will directly inhibit pathogen growth by secretion of metabolites such as the short‐chain fatty acid propionate . Indeed, microbiota‐derived metabolites were shown to modulate susceptibility to bacterial infections, e.g., through disruption of intracellular pH homeostasis of the pathogen , and of viral infection, e.g., through boosting of type I interferon signaling , both in the intestinal tract and in peripheral organs.…”

Section: Impact Of Host–microbiome Circadian Crosstalk On Health Andmentioning

confidence: 99%

Microbiome diurnal rhythmicity and its impact on host physiology and disease risk

2019

View full text Add to dashboard Cite

Host–microbiome interactions constitute key determinants of host physiology, while their dysregulation is implicated in a wide range of human diseases. The microbiome undergoes diurnal variation in composition and function, and this in turn drives oscillations in host gene expression and functions. In this review, we discuss the newest developments in understanding circadian host–microbiome interplays, and how they may be relevant in health and disease contexts. We summarize the molecular mechanisms by which the microbiome influences host function in a diurnal manner, and inversely describe how the host orchestrates circadian rhythmicity of the microbiome. Furthermore, we highlight the future perspectives and challenges in studying this new and exciting facet of host–microbiome interactions. Finally, we illustrate how the elucidation of the microbiome chronobiology may pave the way for novel therapeutic approaches.

show abstract

“…The microbial community in the gastrointestinal tract stimulates production, maintenance of normal structure and functioning of the mucosal lining, hence render the animal protection from pathogenic bacteria (Hanning & Diaz-Sanchez, 2015). Also, some gut commensals produce metabolites which inhibit growth of pathogenic organisms through disrupting intercellular metabolisms (Jacobson et al, 2018).…”

Section: Animal G a S Trointe S Tinal Microb Iomementioning

confidence: 99%

Infection, colonization and shedding of Campylobacter and Salmonella in animals and their contribution to human disease: A review

Rukambile

Sintchenko

Muscatello

et al. 2019

Zoonoses and Public Health

View full text Add to dashboard Cite

Livestock meat and offal contribute significantly to human nutrition as sources of high‐quality protein and micronutrients. Livestock products are increasingly in demand, particularly in low‐ and middle‐income settings where economies are growing and meat is increasingly seen as an affordable and desirable food item. Demand is also driving intensification of livestock keeping and processing. An unintended consequence of intensification is increased exposure to zoonotic agents, and a contemporary emerging problem is infection with Campylobacter and Salmonella spp. from livestock (avian and mammalian), which can lead to disease, malabsorption and undernutrition through acute and chronic diarrhoea. This can occur at the farm, in households or through the food chain. Direct infection occurs when handling livestock and through bacteria shed into the environment, on food preparation surfaces or around the house and surroundings. This manuscript critically reviews Campylobacter and Salmonella infections in animals, examines the factors affecting colonization and faecal shedding of bacteria of these two genera as well as risk factors for human acquisition of the infection from infected animals or environment and analyses priority areas for preventive actions with a focus on resource‐poor settings.

show abstract

A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection

Cited by 350 publications

References 62 publications

Relationship Between Dietary Fiber Intake and Short‐Chain Fatty Acid–Producing Bacteria During Critical Illness: A Prospective Cohort Study

Relationship Between Dietary Fiber Intake and Short‐Chain Fatty Acid–Producing Bacteria During Critical Illness: A Prospective Cohort Study

Microbiome diurnal rhythmicity and its impact on host physiology and disease risk

Infection, colonization and shedding of Campylobacter and Salmonella in animals and their contribution to human disease: A review

Contact Info

Product

Resources

About