A guided walk through Larry Hench’s monumental discoveries

Montazerian, Maziar; Zanotto, Edgar Dutra

doi:10.1007/s10853-017-0804-4

Cited by 45 publications

(30 citation statements)

References 355 publications

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“…The majority of the BGs form a strong interfacial bond with the bone (Hench, 2013). An initial investigation by Piotrowski et al (1975) proved that the interfacial bond between 45S5 Bioglass® and cortical bone in rat and monkey models is equal to or even higher than the strength of the host bone (Piotrowski et al, 1975), and this finding was eventually confirmed clinically (Montazerian and Zanotto, 2017a). As summarized in the previous section, many Sr-doped BGs have excellent biochemical compatibility; however, they have some limitations from a biomechanical viewpoint.…”

Section: Cements Composites Coatings and Glass-ceramics Based On Smentioning

confidence: 98%

Multiple and Promising Applications of Strontium (Sr)-Containing Bioactive Glasses in Bone Tissue Engineering

Kargozar

Montazerian

Fiume

et al. 2019

Front. Bioeng. Biotechnol.

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136

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Improving and accelerating bone repair still are partially unmet needs in bone regenerative therapies. In this regard, strontium (Sr)-containing bioactive glasses (BGs) are highly-promising materials to tackle this challenge. The positive impacts of Sr on the osteogenesis makes it routinely used in the form of strontium ranelate (SR) in the clinical setting, especially for patients suffering from osteoporosis. Therefore, a large number of silicate-, borate-, and phosphate-based BGs doped with Sr and produced in different shapes have been developed and characterized, in order to be used in the most advanced therapeutic strategies designed for the management of bone defects and injuries. Although the influence of Sr incorporation in the glass is debated regarding the obtained physicochemical and mechanical properties, the biological improvements have been found to be substantial both in vitro and in vivo . In the present study, we provide a comprehensive overview of Sr-containing glasses along with the current state of their clinical use. For this purpose, different types of Sr-doped BG systems are described, including composites, coatings and porous scaffolds, and their applications are discussed in the light of existing experimental data along with the significant challenges ahead.

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Section: Cements Composites Coatings and Glass-ceramics Based On Smentioning

confidence: 98%

Multiple and Promising Applications of Strontium (Sr)-Containing Bioactive Glasses in Bone Tissue Engineering

Kargozar

Montazerian

Fiume

et al. 2019

Front. Bioeng. Biotechnol.

Self Cite

136

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“…PerioGlas ® as well has been successful in treating DH. A firm surface affinity of these two formulations to collagen eases dentin bonding, thereby occluding the tubules [101]. Increased amounts of BAG correlate to increased tubule occlusion.…”

Section: Clinical Applications Of Bioactive Glasses In Dentistrymentioning

confidence: 99%

Bioactive Glass Applications in Dentistry

Skallevold

Rokaya

Khurshid

et al. 2019

IJMS

179

113

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At present, researchers in the field of biomaterials are focusing on the oral hard and soft tissue engineering with bioactive ingredients by activating body immune cells or different proteins of the body. By doing this natural ground substance, tissue component and long-lasting tissues grow. One of the current biomaterials is known as bioactive glass (BAG). The bioactive properties make BAG applicable to several clinical applications involving the regeneration of hard tissues in medicine and dentistry. In dentistry, its uses include dental restorative materials, mineralizing agents, as a coating material for dental implants, pulp capping, root canal treatment, and air-abrasion, and in medicine it has its applications from orthopedics to soft-tissue restoration. This review aims to provide an overview of promising and current uses of bioactive glasses in dentistry.

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“…The name Bioglass ® was then trademarked by the University of Florida as the name for the original 45S5 composition and, therefore, it should be used only with reference to that composition and not generally to indicate BGs. The studies conducted by Hench on 45S5 Bioglass ® have been comprehensively reviewed by Montazerian and Zanotto in a recent publication [ 7 ].…”

Section: Introduction—the Invention Of Bioactive Glassmentioning

confidence: 99%

Bioactive Glasses: Where Are We and Where Are We Going?

Baino

Hamzehlou

Kargozar

2018

JFB

372

294

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Bioactive glasses caused a revolution in healthcare and paved the way for modern biomaterial-driven regenerative medicine. The first 45S5 glass composition, invented by Larry Hench fifty years ago, was able to bond to living bone and to stimulate osteogenesis through the release of biologically-active ions. 45S5-based glass products have been successfully implanted in millions of patients worldwide, mainly to repair bone and dental defects and, over the years, many other bioactive glass compositions have been proposed for innovative biomedical applications, such as soft tissue repair and drug delivery. The full potential of bioactive glasses seems still yet to be fulfilled, and many of today’s achievements were unthinkable when research began. As a result, the research involving bioactive glasses is highly stimulating and requires a cross-disciplinary collaboration among glass chemists, bioengineers, and clinicians. The present article provides a picture of the current clinical applications of bioactive glasses, and depicts six relevant challenges deserving to be tackled in the near future. We hope that this work can be useful to both early-stage researchers, who are moving with their first steps in the world of bioactive glasses, and experienced scientists, to stimulate discussion about future research and discover new applications for glass in medicine.

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A guided walk through Larry Hench’s monumental discoveries

Cited by 45 publications

References 355 publications

Multiple and Promising Applications of Strontium (Sr)-Containing Bioactive Glasses in Bone Tissue Engineering

Multiple and Promising Applications of Strontium (Sr)-Containing Bioactive Glasses in Bone Tissue Engineering

Bioactive Glass Applications in Dentistry

Bioactive Glasses: Where Are We and Where Are We Going?

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