A group B
Streptococcus
indexed transposon mutant library to accelerate genetic research on an important perinatal pathogen
Venkata H. Bhavana,
Gideon H. Hillebrand,
Kathyayini P. Gopalakrishna
et al.
Abstract:Group B
Streptococcus
(GBS) is a major contributor to sepsis, meningitis, and pneumonia in newborns. Indexed bacterial mutant libraries accelerate pathogenesis research by allowing rapid screening of genes that contribute to disease. In this study, we created and characterized a large-scale GBS indexed library of
Himar1
mini-transposon mutant strains grown as monocultures from a mixed transposon insertion library that we had previously used for transposon-genome … Show more
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