A Greener Approach to Aspirin Synthesis Using Microwave Irradiation

Montes, Ingrid; Sanabria, David; García, Marilyn; Castro, José Ignacio Fernández del; Fajardo, Johanna

doi:10.1021/ed083p628

Cited by 45 publications

(31 citation statements)

References 10 publications

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“…Aspirin Synthesis using Microwave Technology Aspirin (acetylsalicylic acid) can be prepared from the reaction of salicylic acid and acetic anhydride (Figure 2a) (Montes et al 2006; ACS 2011; Jones 2011). Aspirin was prepared by three different methods involving: (i) conventional synthesis (hot-water bath; 10 min) requiring the addition of concentrated sulfuric acid (H 2 SO 4 ; 3 drops) as a catalyst, (ii) a kitchen microwave oven (1100 W; 4 min at 80% power), and (iii) an industrial microwave synthesis unit (CEM DISCOVER microwave; 15 min at 200 W power; 1 min ramp time; 150 °C; 200 psi) ( Figure 2b).…”

Section: Resultsmentioning

confidence: 99%

Teaching Green Chemistry Principles to Undergraduate Students

Rozov¹,

Brescia²,

Valdez³

et al. 2015

AJS

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The environment is affected by the actions of mankind in multitudinous ways, many of which are detrimental, giving rise to pollution and toxic waste, ultimately making our planet less inhabitable. While remediation and new regulations help to prevent pollution and toxic waste, there is also a need to change the behavior of future generations of consumers and producers of new products. Future chemists and innovators are charged with the responsibility of developing new chemical processes and products that not only meet the needs of our growing population (in terms of energy, clean water and food), but also protect human health and the environment. Green Chemistry is a revolution in the design of molecules that provides new opportunities for economic development while considering the impact on health and the environment. Green Chemistry utilizes a set of guiding principles, originally provided by Anastas and Warner (Green Chemistry: Theory and Practice, 1998), aimed at decreasing/removing the use/generation of hazardous substances in the design, manufacture and application of products. To help improve the creative and innovative thinking behind Green Chemistry, it is important to expose chemistry students to these principles at the undergraduate level. While suitable Green Chemistry experiments are known, successful implementation requires running test trials and performing additional basic research. We have embarked upon the testing and further design of experiments for implementation into an undergraduate laboratory course and report our results in this endeavor.

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Section: Resultsmentioning

confidence: 99%

Teaching Green Chemistry Principles to Undergraduate Students

Rozov¹,

Brescia²,

Valdez³

et al. 2015

AJS

View full text Add to dashboard Cite

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“…The instructor should emphasize that the microwave synthesis is greener than traditional chemistry, 21 demonstrating the reduction of time reaction, the possible absence of solvent and the higher yields. This concept can be easy understood comparing the results obtained during the laboratory practical with the traditional methodology previous described in literature (Table 1).…”

Section: Lesson Planningmentioning

confidence: 99%

Microwave-Assisted Synthesis and Pka Determination of Umbelliferone: An Experiment for the Undergraduate Organic Chemistry Laboratory

Pereira¹,

Franco²,

Vitório³

et al. 2018

Quim. Nova

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A synthetic procedure for obtaining the fluorescent coumarin umbelliferone (7-hydroxycoumarin) and its spectral parameters were fully developed aiming at an undergraduate organic chemistry laboratory class. Umbelliferone is traditionally prepared via Pechmann condensation using malic acid, resorcinol and sulfuric acid as catalyst. The use of domestic microwave oven and the absence of solvent allow our methodology to be simple, fast and easy applied in obtaining umbelliferone at organic chemistry laboratory being greener than classical techniques of synthesis. In this class the student will learn how to measure the potency of a microwave oven, the applicability of this kind of irradiation in the organic synthesis of fluorescent compounds and how to determine the pKa of an organic compound through an UV/VIS spectrometric analysis. These experiments were designed to be suitable for a second and third year undergraduate curriculum.

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“…It was therefore proposed to develop such a procedure that greatly accelerates the reaction. In this respect, microwave heating of the reaction mixture seems to bring about important practical benefits for organic chemistry teaching in general [5,7]. For this purpose, we investigated applicability of commercial microwave oven [8].…”

Section: Introductionmentioning

confidence: 99%

Microwave synthesis of sulfanilic acid

Havlíček

Myška

Tejchman

et al. 2017

Chemistry-Didactics-Ecology-Metrology

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Sulfanilic acid represents an important substance, which is frequently utilized in the industry of azo dyes as well as in drug development of antimicrobials (e.g. of sulfonamides). Students can also meet with such type of compounds in chemistry labs, for example, when they estimate pH by methyl orange indicator or prepare Orange II for textile colouring. Both of these dyes are products of azo coupling of sulfanilic acid as diazonium salt with N,N-dimethylaniline or 2-naphthol, respectively. In the article, we focus on the synthesis of sulfanilic acid as a well-known experiment in the organic chemistry education. The synthesis was modified as the solvent free and microwave assisted experiment under semimicroscale conditions. That experiment is very convenient for the organic chemistry courses in the university or the high school teaching.

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A Greener Approach to Aspirin Synthesis Using Microwave Irradiation

Cited by 45 publications

References 10 publications

Teaching Green Chemistry Principles to Undergraduate Students

Teaching Green Chemistry Principles to Undergraduate Students

Microwave-Assisted Synthesis and Pka Determination of Umbelliferone: An Experiment for the Undergraduate Organic Chemistry Laboratory

Microwave synthesis of sulfanilic acid

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